Protein Alignment IQSEC1 and garz

DIOPT Version :10

• Sequence 1: NP_001363867.1
• Gene: IQSEC1 / 9922
• HGNCID: 29112
• Length: 1222
• Species: Homo sapiens
• Sequence 2: NP_610761.2
• Gene: garz / 36337
• FlyBaseID: FBgn0264560
• Length: 1983
• Species: Drosophila melanogaster
• Alignment Length: 736
• Identity: 184/736 - (25%)
• Similarity: 285/736 - (38%)
• Gaps: 203/736 - (27%)

Human   249 ERLRSSMSENRMSRRIVLSNMRM-QFSFEGPEKVHSSYF--------------EGKQVSVTNDGS 298
            |.||.| :|..:...::|..||: ||:.|..:.:....|              :.|.|:......
  Fly   177 ELLRRS-AEKSLKDMVLLFFMRLPQFAEERSDTMLQKRFTIGDAASGATQEKLKRKTVAQAQTAP 240

Human   299 QLGALV-----SPECGDLSEPTTLKSP----APSSDFADAITELEDAFSRQVKSLAESIDD---- 350
            :..:.|     :|:..:|:.|..||:|    .|:|. |..|.:::...::...:.|.:.:|
  Fly   241 RKSSAVEEPPQTPQSANLTVPGHLKAPILATTPASP-AGNILDMQGKITQTPTTTASTGEDETTV 304

Human   351 ----ALNCRSLHTEEAPALDAARARDTEPQTALHGMDHRKLDEMTASYSDVTLYIDEEELSP-PL 410
                .:...|  ||..|.||......|......:..::  ::.:...::..:...|...||| .|
  Fly   305 PETPVIQVES--TESEPLLDGETGEATSTLAEANSSEY--INSVGVRFTQQSTDHDVTSLSPYGL 365

Human   411 PL----------------SQAGDRPSSTESDLRLRAGGAAPD----YWALAH--KEDKADTDTSC 453
            |.                .|..|....|...|...|...|.|    |..|..  |:|      .|
  Fly   366 PFIQELFRFLIILCNPLDKQNSDSMMHTGLSLLTVAFEVAADNIGKYEGLLELVKDD------LC 424

Human   454 RSTPSLERQEQRLRVEHLPLLTIEPPSDSSVDLS-----DRSERGSLKRQ-SAYERSLGGQQGSP 512
            |:.              :.||:.|..|..:.||.     ..|.||.||.| .||.|.|.....|.
  Fly   425 RNL--------------ISLLSSERLSIFAADLQLCFLLFESLRGHLKFQLEAYLRKLSEIIASD 475

Human   513 KHGPHSGAPKSLPREEPELRPRPPRPLD------------SHLAIN------------GSANRQS 553
            .       ||: |.|..||      .||            :.|.||            ...|..|
  Fly   476 N-------PKT-PYEMREL------ALDNLLQLWRIPGFVTELYINYDCDLYCTDMFESLTNLLS 526

Human   554 KSESDYSDGDNDSINSTS-NSNDTI---------NCS---SESSSRDSLREQTL----SKQTYHK 601
            |    |:....:::.||. .|.||:         ||:   :.|::|:||.|...    |:.:.|.
  Fly   527 K----YTLSATNAVYSTHIISMDTLLSVIDSIERNCAASKNSSNNRESLPEAAPATGGSRHSRHN 587

Human   602 EAR-----NSWDSPAFSNDV----------------------------------IRKRHYRIGLN 627
            ...     :|.:|.|....|                                  .:||....|..
  Fly   588 SGLEGIVIDSGNSVAAEEKVENIASFINASSHRLRLQSGGEGVGITSEQLAKVKQKKRLLSQGTE 652

Human   628 LFNKKPEKGVQYLIERGFVPD--TPVGVAHFLLQRKGLSRQMIGEFLGNRQKQFNRDVLDCVVDE 690
            .||::||||:|||.|.|.:..  .|:.||.||.:..||.::||||:: :::|..:..:|...||.
  Fly   653 RFNQRPEKGIQYLQEHGILNAELDPMQVALFLRENPGLDKKMIGEYI-SKKKNVDSKILINFVDS 716

Human   691 MDFSTMELDEALRKFQAHIRVQGEAQKVERLIEAFSQRYCICNPGVVRQFRNPDTIFILAFAIIL 755
            .||:.:.:|:|||.:....|:.|||..:..::|.||..:...|..   .|.|.|..|.||:|||:
  Fly   717 FDFTGLRVDQALRLYLETFRLPGEAPLIFLVLEHFSDHWHKQNQD---PFANVDAAFRLAYAIIM 778

Human   756 LNTDMYSPNVK----PERKMKLEDFIKNLRGVDDGEDIPREMLMGIYERIRKRELKTNEDHVSQV 816
            ||.|.::.|.|    |   |.||||.|||||::.|||..:|||..::..|:..|:....:....|
  Fly   779 LNMDQHNSNAKRLNVP---MTLEDFTKNLRGLNGGEDFDQEMLAQVFNAIKNEEIVMPAEQTGLV 840

Human   817 QK--VEKLIVGKKPIGSLHPG 835
            ::  ..|:::.:   |..|.|
  Fly   841 RENYQWKVLLRR---GDTHDG 858

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
IQSEC1	NP_001363867.1	Sec7	618..806	CDD:460178	75/193 (39%)
		IQ_SEC7_PH	838..967	CDD:465120
garz	NP_610761.2	PLN03076	<395..>986	CDD:215560	141/512 (28%)
		Sec7	643..830	CDD:460178	75/193 (39%)