Protein Alignment IQSEC1 and sec74

DIOPT Version :10

• Sequence 1: NP_001363867.1
• Gene: IQSEC1 / 9922
• HGNCID: 29112
• Length: 1222
• Species: Homo sapiens
• Sequence 2: NP_594894.2
• Gene: sec74 / 2542073
• PomBaseID: SPAC26F1.01
• Length: 928
• Species: Schizosaccharomyces pombe
• Alignment Length: 1011
• Identity: 196/1011 - (19%)
• Similarity: 332/1011 - (32%)
• Gaps: 358/1011 - (35%)

Human   377 TALHGMDHRKLDEMTASYSDVTLYIDEEELSPPLPLSQAGDRPSSTESDLRLRAGGAAPDYWALA 441
            :||||     ||||.:::..          |||||..:.|      :|.||.          ||.
pombe    11 SALHG-----LDEMVSAHKP----------SPPLPSRRKG------KSALRS----------ALE 44

Human   442 HKEDKADTD---TSCRSTPSLERQEQRLRVEHLPLLTIEPPSDSSVDLSDR-----SERGSLKRQ 498
            .|..|:.:.   |....||.:..|       |.|:.:.. ..||:.||..:     |::.|.|..
pombe    45 KKNRKSKSKPKVTITSDTPKVSSQ-------HSPVSSAY-TGDSTTDLDSKSGHSSSQKLSNKVS 101

Human   499 SAYERSLGGQQGSPKHGPHSGAPKSLPREE------------PELRPRPPRPLDSHLAINGS--- 548
            ||.:.::..:..|.|......:...||...            |:.:.||.......|: |.|
pombe   102 SALKLTIPKRWRSSKSSSSQCSSPFLPTSSSNGHGDDASLNLPDKKSRPSSQSSIFLS-NWSTIF 165

Human   549 ANRQSKSESDYSDGDNDSINSTSNSNDTINCSSE-------SSSRDSLREQTL---SKQTYHKEA 603
            ::..|.::|..|.....:|...:.|..:|..|..       |.||.|:...|.   ||......:
pombe   166 SSNASPTDSQLSPTHTSTIAELAASTLSIFPSGSYAGSTFGSPSRSSIDSSTYLPRSKSVNSLSS 230

Human   604 RNSWDSPAFSNDVIRK----------RHYRIGLNLFNKKPE-----------KGVQYLIERGFVP 647
            ..|..:||.:...:.:          :|..:.|:.| ..|:           :.|::.|.:.|.|
pombe   231 NFSARTPASNQSSVSEDFGAAPNCDHKHNSVTLSDF-ALPDIDQHDTVETILEKVEFTIPKQFTP 294

Human   648 DTPVGVAHFLLQRKGLSRQMIGEFLGNRQKQFNRDVLDCVVDEMDFSTMELDEALRKFQAHIRVQ 712
                     .:..:|.|..:         |...|..|..|    :|..:.||.|||||.|...:.
pombe   295 ---------AILSQGTSSLL---------KLCLRKYLSVV----NFKCISLDMALRKFLAVYVLP 337

Human   713 GEAQKVERLIEAFSQRYCICNPGVVRQFRNPDTIFILAFAIILLNTDMYSPNVKPERKMKLEDFI 777
            .|.|:::|::..||.:|..|||.:   :.:.|..:||.|::::|:||.:  |:...:||...:||
pombe   338 NETQQIDRVLSTFSDQYFHCNPDL---YDSSDECYILTFSLMILHTDFF--NIHNRQKMTRAEFI 397

Human   778 KNLRGVDDGEDIPR---EMLMGIYERI-------------------------------------R 802
            .|       .::|.   |:|...|:.|                                     :
pombe   398 SN-------TNLPTILPEILECFYDNITYTPFVHVEHIGCVVTSPSNEKPSLSQRLGDSQFRLTK 455

Human   803 KRELKTNEDHVSQVQKVEKLIVG----------KKPIGSLHPGLGCVLSLPHRRLVCYCRLFE-- 855
            :....|..||    |.:::.:.|          .|.|.|:...    :..|.|......:.|.
pombe   456 RNTFATESDH----QALQEQLTGFRINLDSILDLKKIDSVRTS----IESPTRTADDLYKEFARA 512

Human   856 -----VPDPNKPQKLGLH---QREIFLFNDLLVVTKIF--------QKKKNSVTYSFRQ-SFSLY 903
                 |...::||....|   ..|....|..::..|:|        :|.:.....|.|: ...|.
pombe   513 PFLQIVSHRSQPQAFSYHFEPSAESESTNPAIINVKVFKLGILIQNEKVRKDRLLSNREVGVILT 577

Human   904 GMQVLLFENQYYPNGI--------------------RLTS-----SVPGADI------------- 930
            ..|::.|:|.|:.:|:                    .|||     .:|.:|:
pombe   578 SSQLMFFKNVYWISGLLDQLEDFKRSHSFSPCYFSPHLTSLSADYIIPLSDLVAYGDGSRIENEL 642

Human   931 --------------------------KVLINFNAP------NPQDR------------------- 944
                                      .|.|||.:.      .|::|
pombe   643 YSFSVKQKNQRTHVFSVTNVDELNDWLVKINFVSTFATAGLAPRERLPCVESSDKSIKASVSVLP 707

Human   945 ---------KKFTDDLRESIAEVQEMEKHRIESELEKQKGVVRPSMSQCSSLKKESGN------- 993
                     .|.:.:.|..:.|..::..:.:::.:.|.:..:|...|:.:..::.:.|
pombe   708 DIYEDSDAMSKASKETRSEVLECSKVRVYIVQNRIYKLEEALRQGESKMTVQRRNAANILHLEPI 772

Human   994 ------------GTLSRACLDDSY------ASGEGLKR-----SALSSSLRDLSEAGKRGRRSSA 1035
                        .||.:..|....      .|.:.||.     |.|...||.:..:...|:.:::
pombe   773 QSRTRIRLARCSNTLKKNMLAQMIEIQKFKISIKFLKEDLEMDSHLQDYLRSVFPSSVMGKENAS 837

Human  1036 GS--LESNVEGSIISSPHMRR---RATSTRECPSRPH-QTMPNSSSLLGSLFGSKRGKPPPQAHL 1094
            ..  ||||....  |:|.:||   |...|.|...... :::.|.|   |.......||.|....
pombe   838 EDTILESNFRNH--SNPSVRRSNLRVGKTVESVQNTKLKSVENDS---GKAETETVGKNPEVVR- 896

Human  1095 PSAPALPPPHPPVVLPHLQH--SVAGHHLGPPEGLP 1128
                     ..|..||::.:  :|.||.....| ||
pombe   897 ---------KSPAKLPNIANIMTVNGHRYSVVE-LP 922

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
IQSEC1	NP_001363867.1	Sec7	618..806	CDD:460178	50/248 (20%)
		IQ_SEC7_PH	838..967	CDD:465120	34/245 (14%)
sec74	NP_594894.2	Sec7	<306..422	CDD:460178	40/131 (31%)
		PH	549..676	CDD:214574	19/126 (15%)