Protein Alignment IQSEC1 and bris-1

DIOPT Version :10

• Sequence 1: NP_001363867.1
• Gene: IQSEC1 / 9922
• HGNCID: 29112
• Length: 1222
• Species: Homo sapiens
• Sequence 2: NP_500420.3
• Gene: bris-1 / 177142
• WormBaseID: WBGene00019726
• Length: 640
• Species: Caenorhabditis elegans
• Alignment Length: 858
• Identity: 253/858 - (29%)
• Similarity: 358/858 - (41%)
• Gaps: 258/858 - (30%)

Human   200 LSESYELSSDLQDKQVEMLERKYGGRLVTRHAARTIQTAFRQYQMNKNFERLRSSMS--ENRMSR 262
            :.:.|:||.:|..::|::|||:|||..:...||..||.|:|:|.:.|.:..:|....  .:.:..
 Worm    18 VQKGYQLSDELALRKVQVLERRYGGMQLAHRAATVIQRAWREYCIMKQWMVIRHKHDTIPDHLDA 82

Human   263 RIVLSNMRMQFSFEGPEKVHSSYFEGKQVSVTNDGSQLGALVSPECGDLSEPTTLKSPAPSSDFA 327
            |..:||.                 :..::|:|
 Worm    83 RCGVSNS-----------------QRNELSLT--------------------------------- 97

Human   328 DAITELEDAFSRQVKSLAESIDDALNCRSLHTEEAPALDAARARDTEPQTALHGMDHRKLDEMTA 392
                      ||...||:..:......||...:.:|...|       |...::..:...:|.:
 Worm    98 ----------SRYATSLSAQLRIDRAARSTTLDRSPPSPA-------PPVLVNLQNSNMIDSL-- 143

Human   393 SYSDVTLYIDEEELSPPLPLSQAGDRPSSTESDLRLRAGGAAPDYWALAHKEDKADTDTSCRSTP 457
                         :||.|     |:|          |.|.||                  .|..|
 Worm   144 -------------MSPRL-----GNR----------RFGAAA------------------SRCAP 162

Human   458 SLERQEQRLRVEHLPLLTIEPPSDSSVDLSDRSERGSLKRQSAYERSLGGQQGSPKHGP-HSGAP 521
            :         ...|....:..|..|.|:                            |.| ||
 Worm   163 A---------AAELTSTEVWLPRPSLVN----------------------------HNPAHS--- 187

Human   522 KSLPREEPELRPRPPRPLDSHLAINGSANRQSKSESDYSDGDNDSINSTSNSNDTINCSSESSSR 586
            .||||            ||.|..       ..:|||  |:|
 Worm   188 NSLPR------------LDKHRV-------HERSES--SNG------------------------ 207

Human   587 DSLREQTLSKQTYHKEARNSWDSPAFSNDVIRKRHYRIGLNLFNKKPEKGVQYLIERGFVPDTPV 651
                    .|::..|..|...|..       |||.|||.||.||||||:|||.|...|||.::|.
 Worm   208 --------RKKSEVKPPRQMTDQE-------RKRQYRIALNFFNKKPERGVQLLTAWGFVKNSPD 257

Human   652 GVAHFLLQRKGLSRQMIGEFLGNRQKQFNRDVLDCVVDEMDFSTMELDEALRKFQAHIRVQGEAQ 716
            .:|..|..|:|||:.||||::|.....::..||......:|...:|:|.||||......:..||:
 Worm   258 SLASLLFGRRGLSKSMIGEYIGTLHSPYHSLVLKYFTALIDIRGLEVDVALRKAMQFFILPKEAE 322

Human   717 KVERLIEAFSQRYCICNPGVVRQFRNP-DTIFILAFAIILLNTDMYSPNVKPERKMKLEDFIKNL 780
            |::|:|:||:..|...||.....:|.. |||.:|:||||:||||::|||||  ::|...||:|||
 Worm   323 KIDRIIQAFALHYSKSNPKRTSHYRGGWDTIHLLSFAIIMLNTDLHSPNVK--QRMTQADFVKNL 385

Human   781 RGVD------DGEDIPREMLMGIYERIRKRELKTNEDHVSQVQKVEKLIVGK-KPIGSLHPGLGC 838
            ||.|      :||||.|:.|.|||:||:|.|||..:|||:|||:|::.|||| ||
 Worm   386 RGQDKISGEKNGEDIDRKTLEGIYDRIKKDELKAGDDHVAQVQRVDRAIVGKDKP---------- 440

Human   839 VLSLPHRRLVCYCRLFEVPDPNKPQKLGLHQREIFLFNDLLVVTKIFQKKKNSV---TYSFRQSF 900
            .|:...|||||||||.:|.||.|.|.....:|::|||||::||.|..::...|:   ||:.:|..
 Worm   441 RLTETPRRLVCYCRLQQVSDPTKRQSSSARERDVFLFNDMIVVAKGVRRGSTSMAGCTYTLKQWT 505

Human   901 SLYGMQVLLFENQYYPNGIRLTSSVPGADIKVLINFNAPNPQDRKKFTDDLRESIAEVQEMEKHR 965
            .|.|..|..|:...|..|  ||.:.|..|   .|:|||.|.:||..|..|:.|||.|..|||:.|
 Worm   506 LLLGAHVTEFQRGQYEFG--LTITCPNKD---KIHFNARNFEDRCHFVADVTESIREATEMEQVR 565

Human   966 IESELEKQ-KGVVRPSMSQCSSLKKESGNGTLSRACLDDSYASGEGLKRSALSSSLRDLSEAGKR 1029
            :|.|:|:. ...:||...:.|.|..           :|:|.....|...||.||:..........
 Worm   566 LEMEMEQHTTTTIRPDNQRDSGLPD-----------MDESMKLSNGSNSSAGSSNSSTNGVNNSS 619

Human  1030 GRRSSAGSLESNV 1042
            .||.|..||:|.|
 Worm   620 FRRLSFNSLDSGV 632

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
IQSEC1	NP_001363867.1	Sec7	618..806	CDD:460178	91/194 (47%)
		IQ_SEC7_PH	838..967	CDD:465120	55/131 (42%)
bris-1	NP_500420.3	Sec7	224..417	CDD:238100	91/194 (47%)
		PH_IQSEC	445..573	CDD:270128	57/132 (43%)