DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ATP2C2 and Atp2c2

DIOPT Version :9

Sequence 1:	NP_001273456.2	Gene:	ATP2C2 / 9914	HGNCID:	29103	Length:	975	Species:	Homo sapiens
Sequence 2:	NP_081198.1	Gene:	Atp2c2 / 69047	MGIID:	1916297	Length:	944	Species:	Mus musculus

Alignment Length:	972	Identity:	799/972 - (82%)
Similarity:	867/972 - (89%)	Gaps:	29/972 - (2%)

- Green bases have known domain annotations that are detailed below.

Human     4 GRVSEFLKKLGFSGGGRQYQALEKDEEEALIDEQSELKAIEKEKKVTALPPKEACKCQKEDLARA 68
            ||..:||:||.|.|...:|:|||:||.|.|||||.||||||:||.|.||||.|||||.:|:||||
Mouse     2 GRRLKFLQKLAFLGQNHRYKALERDEVETLIDEQCELKAIEREKTVAALPPGEACKCSREELARA 66

Human    69 FCVDLHTGLSEFSVTQRRLAHGWNEFVADNSEPVWKKYLDQFKNPLILLLLGSALVSVLTKEYED 133
            |.|||.:|||||:|.||||.|||||||.||:|||||||||||:||||||||||::||||||||||
Mouse    67 FHVDLDSGLSEFAVAQRRLVHGWNEFVTDNAEPVWKKYLDQFRNPLILLLLGSSVVSVLTKEYED 131

Human   134 AVSIATAVLVVVTVAFIQEYRSEKSLEELTKLVPPECNCLREGKLQHLLARELVPGDVVSLSIGD 198
            |||||.|||:||||.||||||||||||||||||||||||||:|||:|:|||:|||||:||||:||
Mouse   132 AVSIALAVLIVVTVGFIQEYRSEKSLEELTKLVPPECNCLRDGKLRHMLARDLVPGDIVSLSMGD 196

Human   199 RIPADIRLTEVTDLLVDESSFTGEAEPCSKTDSPLTGGGDLTTLSNIVFMGTLVQYGRGQGVVIG 263
            ||||||||||||||||||||||||.|||.||||||..||||:||||:||||||||.|:|||||||
Mouse   197 RIPADIRLTEVTDLLVDESSFTGEVEPCGKTDSPLADGGDLSTLSNVVFMGTLVQCGKGQGVVIG 261

Human   264 TGESSQFGEVFKMMQAEETPKTPLQKSMDRLGKQLTLFSFGIIGLIMLIGWSQGKQLLSMFTIGV 328
            |||.||||||||||:||||||||||||||:||||||:||||||||:||:||.|||..|||||:||
Mouse   262 TGEQSQFGEVFKMMRAEETPKTPLQKSMDKLGKQLTIFSFGIIGLLMLVGWVQGKPFLSMFTVGV 326

Human   329 SLAVAAIPEGLPIVVMVTLVLGVLRMAKKRVIVKKLPIVETLGCCSVLCSDKTGTLTANEMTVTQ 393
            |||||||||||||||||||||||||||||||||||||||||||||:|:||||||||||||||.||
Mouse   327 SLAVAAIPEGLPIVVMVTLVLGVLRMAKKRVIVKKLPIVETLGCCNVICSDKTGTLTANEMTATQ 391

Human   394 LVTSDGLRAEVSGVGYDGQGTVCLLPSKEVIKEFSNVSVGKLVEAGCVANNAVIRKNAVMGQPTE 458
            ||||||..||||||||.|:|||||||||||||.|.||||||||||||||||||||||||||||||
Mouse   392 LVTSDGFHAEVSGVGYSGEGTVCLLPSKEVIKGFDNVSVGKLVEAGCVANNAVIRKNAVMGQPTE 456

Human   459 GALMALAMKMDLSDIKNSYIRKKEIPFSSEQKWMAVKCSLKTEDQEDIYFMKGALEEVIRYCTMY 523
            |||:.|||||:|..||:||:||||||||||||||||:|..|:||.|||||||||.||||.:|:||
Mouse   457 GALVVLAMKMNLGSIKDSYVRKKEIPFSSEQKWMAVRCGPKSEDGEDIYFMKGAFEEVIHHCSMY 521

Human   524 NNGGIPLPLTPQQRSFCLQEEKRMGSLGLRVLALASGPELGRLTFLGLVGIIDPPRVGVKEAVQV 588
            |||||||||||||:|:|.||||:|||||||||||||||||||||||||||||||||.||||||||
Mouse   522 NNGGIPLPLTPQQKSYCQQEEKKMGSLGLRVLALASGPELGRLTFLGLVGIIDPPRAGVKEAVQV 586

Human   589 LSESGVSVKMITGDALETALAIGRNIGLCNGKLQAMSGEEVDSVEKGELADRVGKVSVFFRTSPK 653
            ||||||||||:|||||||||||||.|||||.||:|||||||:..|:|.||.||.:||||||||||
Mouse   587 LSESGVSVKMVTGDALETALAIGRTIGLCNEKLKAMSGEEVEGTEQGALAARVRQVSVFFRTSPK 651

Human   654 HKLKIIKALQESGAIVAMTGDGVNDAVALKSADIGIAMGQTGTDVSKEAANMILVDDDFSAIMNA 718
            ||:||||||||||||||||||||||:|||||||||||||||||||||||||||||||||||||:|
Mouse   652 HKVKIIKALQESGAIVAMTGDGVNDSVALKSADIGIAMGQTGTDVSKEAANMILVDDDFSAIMSA 716

Human   719 VEEGKGIFYNIKNFVRFQLSTSISALSLITLSTVFNLPSPLNAMQILWINIIMDGPPAQRSSQKT 783
            |||||||||||||||||||||||:||||||||||.|||||||||||||:||||||||||
Mouse   717 VEEGKGIFYNIKNFVRFQLSTSIAALSLITLSTVCNLPSPLNAMQILWVNIIMDGPPAQ------ 775

Human   784 EVCCTAVRLGVEGRGESTWAGRAGLGVEPVDKDAFRQPPRSVRDTILSRALILKILMSAAIIISG 848
                                   .|||||||:||.|:|||||.||||:|||||::|||||:||.|
Mouse   776 -----------------------SLGVEPVDRDALRRPPRSVGDTILNRALILRVLMSAAVIIGG 817

Human   849 TLFIFWKEMPEDRASTPRTTTMTFTCFVFFDLFNALTCRSQTKLIFEIGFLRNHMFLYSVLGSIL 913
            ||||||:|:|.:..||||||||.|||||||||||||:|||||||||||||.||.|||||||||:|
Mouse   818 TLFIFWREIPANGTSTPRTTTMAFTCFVFFDLFNALSCRSQTKLIFEIGFFRNRMFLYSVLGSLL 882

Human   914 GQLAVIYIPPLQRVFQTENLGALDLLFLTGLASSVFILSELLKLCEKYCCSPKRVQMHPEDV 975
            |||||||.||||:|||||||.|||||.|||||||||||||||||.||:....:..||.||.|
Mouse   883 GQLAVIYAPPLQKVFQTENLSALDLLLLTGLASSVFILSELLKLWEKFLSRARPTQMLPEAV 944

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ATP2C2	NP_001273456.2	ATPase-IIA2_Ca	55..960	CDD:130585	759/904 (84%)
		Cation_ATPase_N	63..125	CDD:279080	49/61 (80%)
		E1-E2_ATPase	149..368	CDD:278548	194/218 (89%)
		Cation_ATPase	441..523	CDD:289987	65/81 (80%)
		COG4087	<625..709	CDD:226572	73/83 (88%)
		Cation_ATPase_C	756..957	CDD:279079	145/200 (73%)
Atp2c2	NP_081198.1	ATPase-IIA2_Ca	54..929	CDD:130585	759/903 (84%)
		Cation_ATPase_N	61..123	CDD:279080	49/61 (80%)
		Interaction with ORAI1. /evidence=ECO:0000250\|UniProtKB:O75185	69..93		18/23 (78%)
		E1-E2_ATPase	135..366	CDD:278548	203/230 (88%)
		Cation_ATPase	439..521	CDD:289987	65/81 (80%)
		COG4087	584..707	CDD:226572	108/122 (89%)
		Cation_ATPase_C	754..927	CDD:279079	146/201 (73%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C83970696
Domainoid	1	1.000	532	1.000	Domainoid score	I6634
eggNOG	1	0.900	-	-		E2759_KOG0202
HGNC	1	1.500	-	-
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H73463
Inparanoid	1	1.050	1578	1.000	Inparanoid score	I2689
Isobase	0	0.000	Not matched by this tool.
NCBI	1	1.000	-	-
OMA	1	1.010	-	-		QHG53587
OrthoDB	1	1.010	-	-		D100699at2759
OrthoFinder	1	1.000	-	-		FOG0000231
OrthoInspector	1	1.000	-	-		oto122235
orthoMCL	1	0.900	-	-		OOG6_100158
Panther	1	1.100	-	-	LDO	PTHR42861
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R11178
SonicParanoid	1	1.000	-	-		X1037
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	18	18.300