DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment ATP2C2 and SERCA

DIOPT Version :9

Sequence 1:NP_001273456.2 Gene:ATP2C2 / 9914 HGNCID:29103 Length:975 Species:Homo sapiens
Sequence 2:NP_726381.1 Gene:SERCA / 49297 FlyBaseID:FBgn0263006 Length:1020 Species:Drosophila melanogaster


Alignment Length:1020 Identity:331/1020 - (32%)
Similarity:499/1020 - (48%) Gaps:182/1020 - (17%)


- Green bases have known domain annotations that are detailed below.


Human    69 FCVDLHTGLSEFSVTQRRLAHGWNEFVADNSEPVWKKYLDQFKNPLILLLLGSALVS---VLTKE 130
            |..|...||:...:...:..:|.||...:..:.:|:..|:||.:.|:.:||.:|::|   .|.:|
  Fly    16 FGTDPERGLTLDQIKANQKKYGPNELPTEEGKSIWQLVLEQFDDLLVKILLLAAIISFVLALFEE 80

Human   131 YEDAVSIATAVLVVV-------TVAFIQEYRSEKSLEELTKLVPPECNCLREGK--LQHLLAREL 186
            :|:..:.....||::       .|...||..:|.::|.|.:..|.....:|:.|  :|.:.|:|:
  Fly    81 HEETFTAFVEPLVILLILIANAVVGVWQERNAESAIEALKEYEPEMGKVVRQDKSGIQKVRAKEI 145

Human   187 VPGDVVSLSIGDRIPADIRLTEV--TDLLVDESSFTGEAEPCSK-TDS---PLTGGGDLTTLSNI 245
            ||||:|.:|:||:||||||:|.:  |.|.:|:|..|||:....| ||:   |.....|   ..||
  Fly   146 VPGDLVEVSVGDKIPADIRITHIYSTTLRIDQSILTGESVSVIKHTDAIPDPRAVNQD---KKNI 207

Human   246 VFMGTLVQYGRGQGVVIGTGESSQFGEVFKMMQAEETPKTPLQKSMDRLGKQLTLFSFGIIGLIM 310
            :|.||.|..|:.:|||||||.|:..|::...|...|..|||||:.:|..|:||:    .:|.:|.
  Fly   208 LFSGTNVAAGKARGVVIGTGLSTAIGKIRTEMSETEEIKTPLQQKLDEFGEQLS----KVISVIC 268

Human   311 LIGW--------------SQGKQLLSMFTIGVSLAVAAIPEGLPIVVMVTLVLGVLRMAKKRVIV 361
            :..|              |..|..:..|.|.|:|||||||||||.|:...|.||..|||||..||
  Fly   269 VAVWAINIGHFNDPAHGGSWIKGAIYYFKIAVALAVAAIPEGLPAVITTCLALGTRRMAKKNAIV 333

Human   362 KKLPIVETLGCCSVLCSDKTGTLTANEMTVTQLVTSDG--------LRAEVSGVGYDGQGTVCLL 418
            :.||.||||||.||:|||||||||.|:|:|:::...|.        |..|::|..|:..|.|.|.
  Fly   334 RSLPSVETLGCTSVICSDKTGTLTTNQMSVSRMFIFDKVEGNDSSFLEFEMTGSTYEPIGEVFLN 398

Human   419 PSK------EVIKEFSNVSVGKLVEAGCVANNAVIRKNAV------MGQPTEGALMALAMKMDLS 471
            ..:      :.::|.|.:.:        :.|::.|..|..      :|:.||.||:.||.|::..
  Fly   399 GQRIKAADYDTLQELSTICI--------MCNDSAIDYNEFKQAFEKVGEATETALIVLAEKLNSF 455

Human   472 DIKNSYIR----------------KKE--IPFSSEQKWMAVKCS------LKTEDQEDIYFMKGA 512
            .:..|.:.                |||  :.||.::|.|:..|:      |.|..:   .|:|||
  Fly   456 SVNKSGLDRRSAAIACRGEIETKWKKEFTLEFSRDRKSMSSYCTPLKASRLGTGPK---LFVKGA 517

Human   513 LEEVIRYCTMYNNGGIPLPLTPQQRSFCLQEEKRMG----SLGLRVLALASGP------ELG--- 564
            .|.|:..||....|...:|||...::..|....:.|    :|....||:|..|      :||   
  Fly   518 PEGVLERCTHARVGTTKVPLTSALKAKILALTGQYGTGRDTLRCLALAVADSPMKPDEMDLGDST 582

Human   565 -------RLTFLGLVGIIDPPRVGVKEAVQVLSESGVSVKMITGDALETALAIGRNIGL------ 616
                   .|||:|:||::||||..|.:::.....:|:.|.:||||...||.||.|.||:      
  Fly   583 KFYQYEVNLTFVGVVGMLDPPRKEVFDSIVRCRAAGIRVIVITGDNKATAEAICRRIGVFAEDED 647

Human   617 CNGKLQAMSGEEVDSVEKGELADRVGKVSVFFRTSPKHKLKIIKALQESGAIVAMTGDGVNDAVA 681
            ..||  :.||.|.|.:...|....|.:..:|.|..|:||.||::.||....|.||||||||||.|
  Fly   648 TTGK--SYSGREFDDLSPTEQKAAVARSRLFSRVEPQHKSKIVEFLQSMNEISAMTGDGVNDAPA 710

Human   682 LKSADIGIAMGQTGTDVSKEAANMILVDDDFSAIMNAVEEGKGIFYNIKNFVRFQLSTSISALSL 746
            ||.|:|||||| :||.|:|.||.|:|.||:||:|::|||||:.|:.|:|.|:|:.:|::|..:..
  Fly   711 LKKAEIGIAMG-SGTAVAKSAAEMVLADDNFSSIVSAVEEGRAIYNNMKQFIRYLISSNIGEVVS 774

Human   747 ITLSTVFNLPSPLNAMQILWINIIMDGPPAQRSSQKTEVCCTAVRLGVEGRGESTWAGRAGLGVE 811
            |.|:....||..|..:|:||:|::.||.||                             ..||..
  Fly   775 IFLTAALGLPEALIPVQLLWVNLVTDGLPA-----------------------------TALGFN 810

Human   812 PVDKDAFRQPPRSVRDTILSRALILKILMSAAIIISGTL------FIFWKEMPE----------- 859
            |.|.|...:|||...:.::|..|..:.:.....:.:.|:      |:|..|.|:           
  Fly   811 PPDLDIMEKPPRKADEGLISGWLFFRYMAIGFYVGAATVGAAAWWFVFSDEGPKLSYWQLTHHLS 875

Human   860 -----DR--------ASTPRTTTMTFTCFVFFDLFNALTCRSQTKLIFEIGFLRNHMFLYSVLGS 911
                 |.        .|.|...||..:..|..::.||:...|:.:.:..:....|...:.|:..|
  Fly   876 CLGGGDEFKGVDCKIFSDPHAMTMALSVLVTIEMLNAMNSLSENQSLITMPPWCNLWLIGSMALS 940

Human   912 ILGQLAVIYIPPLQRVFQTENLGALDLLFLTGLASSVFILSELLK 956
            ......::|:..|..|||...|.|.:.:.:...:..|.:|.|.||
  Fly   941 FTLHFVILYVDVLSTVFQVTPLSAEEWITVMKFSIPVVLLDETLK 985

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ATP2C2NP_001273456.2 ATPase-IIA2_Ca 55..960 CDD:130585 331/1020 (32%)
Cation_ATPase_N 63..125 CDD:279080 15/55 (27%)
E1-E2_ATPase 149..368 CDD:278548 97/240 (40%)
Cation_ATPase 441..523 CDD:289987 30/111 (27%)
COG4087 <625..709 CDD:226572 44/83 (53%)
Cation_ATPase_C 756..957 CDD:279079 49/231 (21%)
SERCANP_726381.1 P-type_ATPase_SERCA 5..989 CDD:319778 331/1020 (32%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG0202
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG53587
OrthoDB 1 1.010 - - D100699at2759
OrthoFinder 1 1.000 - - FOG0000231
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100158
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
65.730

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