Protein Alignment TMCC2 and Dmtn

DIOPT Version :10

• Sequence 1: NP_055673.2
• Gene: TMCC2 / 9911
• HGNCID: 24239
• Length: 709
• Species: Homo sapiens
• Sequence 2: NP_001163531.1
• Gene: Dmtn / 40792
• FlyBaseID: FBgn0037443
• Length: 679
• Species: Drosophila melanogaster
• Alignment Length: 768
• Identity: 252/768 - (32%)
• Similarity: 347/768 - (45%)
• Gaps: 208/768 - (27%)

Human     6 SDELQQQQGEEDGAGLEDAASHLPGADLR-PGETTGAN-----SAGGPTSDAGAAAAPNPGPRSK 64
            ::::.:::..|..|..:.||:...||... .|.|.|.:     :|||.||.:|.|:|......|.
  Fly    45 TEQMSRERASEAAAATQTAAATAGGATAHSAGGTAGGSAAATTTAGGATSGSGTASANTNSNSSA 109

Human    65 PPDLKKIQQLS--------EGSMFGHGL------KHLFHSRRRSREREHQTSQDSQQHQQQQG-- 113
            ........|.:        .||:...|:      .|....|||||||:.:|      |...||
  Fly   110 SSSTVAAAQAAVYSGGNTVTGSLGSAGVVARGFRSHSPTHRRRSRERQRRT------HGSDQGGL 168

Human   114 -----------MSDHDSPDEKERSPEMHRVSYAMSLHDLPARPTAFNRVLQQIRSRPSIKRGASL 167
                       |:|...|                                         ::|...
  Fly   169 LAYSGLVGVNDMTDFLGP-----------------------------------------QQGGGG 192

Human   168 HSSSGGGSSGSSSRRTKSSSLEPQR--GSPHLLRKAPQDSSLAAILHQHQCRPRSSSTTDTALLL 230
            ....|||..|........|.||..|  |:.........|...::.....:|..||||.
  Fly   193 GGGGGGGGGGGGGSAGTGSGLEDSRLSGNEDYYSSFVSDEFDSSKKVHRRCHERSSSV------- 250

Human   231 ADGSNVYLLAEEAEGIGDKVDKGDLVALSLPAGHGDTDGPISLDVPDGAPDPQRTKAAIDHLHQK 295
                                                                    .|||.|:.|
  Fly   251 --------------------------------------------------------QAIDRLNTK 259

Human   296 ILKITEQIKIEQEARDDNVAEYLKLANNADKQQVSRIKQVFEKKNQKSAQTIAQLHKKLEHYRRR 360
            |....|.|:.||.||||||.||||||.:|||||:.|||.||||||||||..|:||.|||::|.:|
  Fly   260 IQCTKESIRQEQTARDDNVNEYLKLAASADKQQLQRIKAVFEKKNQKSAHNISQLQKKLDNYTKR 324

Human   361 LKEIEQN-----GPSRQPKDVLRDMQQGLKDVGANVRAGISGFGGGVVEGVKGSLSGLSQATHTA 420
            .|:::.:     ...|||::||||:.|||::||.|:|.||:||.|                   :
  Fly   325 AKDLQNHQFQTKSQHRQPREVLRDVGQGLRNVGGNIRDGITGFSG-------------------S 370

Human   421 VVSKPREFASLIRNKFGSADNIAHLKDPLEDGPPEEAARALSGSATLVSSPKYGSDDECSSASAS 485
            |:|||||||.||:|||||||||..:.:....|.....|..| ||..|...|..|:       |..
  Fly   371 VMSKPREFAHLIKNKFGSADNINQMSEAELQGMQSANADVL-GSERLQQVPGAGT-------STG 427

Human   486 SAGAGSNSGAGPGGALGSPKSNALYGA----------PGN--------------LDALLEELREI 526
            |.|.|.|:..|..|: |:.|.|:..|:          ||.              |..||.||.|.
  Fly   428 SGGGGQNNNTGGAGS-GTGKFNSDNGSECSSVTSESIPGGSGKSQSGASQYHIVLKTLLTELAER 491

Human   527 KEGQSHLEDSMEDLKTQLQRDYTYMTQCLQEERYRYERLEEQLNDLTELHQNEMTNLKQELASME 591
            |.....|::.:|.|:|. |:::..:|..|:.||||.|.||||:||||||||||:.||||.:|.||
  Fly   492 KAENEKLKERIERLETG-QKEFNNLTATLESERYRAEGLEEQINDLTELHQNEIENLKQTIADME 555

Human   592 EKVAYQSYERARDIQEAVESCLTRVTKLELQQQQQQVVQLEGVENANARALLGKFINVILALMAV 656
            |||.|||.||.||:.|.:|:|.||::|:| ...|||.|.:||::|:|||||:.|.|||:|.::.|
  Fly   556 EKVQYQSDERLRDVNEVLENCQTRISKME-HMSQQQYVTVEGIDNSNARALVVKLINVVLTILQV 619

Human   657 LLVFVSTIANFITPLMKTRLRITSTTLLVLVLFLLWKHW----DSLTYLLEHV 705
            :|:.|:|.|..|.|.:|||:|:.:|.|.:..:..:.:.|    |..:.|:.|:
  Fly   620 VLLLVATAAGIIMPFLKTRVRVLTTFLSICFVIFVIRQWPDVQDIGSGLVRHL 672

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TMCC2	NP_055673.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..143		37/169 (22%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	158..202		10/45 (22%)
		Tmemb_cc2	285..695	CDD:463036	195/438 (45%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	444..500		14/55 (25%)
Dmtn	NP_001163531.1	Tmemb_cc2	249..658	CDD:463036	196/501 (39%)