Protein Alignment RABGAP1L and TBC1D5

DIOPT Version :10

• Sequence 1: NP_001353375.1
• Gene: RABGAP1L / 9910
• HGNCID: 24663
• Length: 1051
• Species: Homo sapiens
• Sequence 2: NP_731780.1
• Gene: TBC1D5 / 41628
• FlyBaseID: FBgn0038129
• Length: 654
• Species: Drosophila melanogaster
• Alignment Length: 621
• Identity: 118/621 - (19%)
• Similarity: 216/621 - (34%)
• Gaps: 183/621 - (29%)

Human   507 EKILYSWGELLGKWHSNLGARPKGLSTLVKSG---------VPEALRAEV-------W------- 548
            |:....|..||    .||.|.|:.|.....:|         |..||...|       |
  Fly    42 ERYRQEWQVLL----ENLDADPESLRQSAFAGDLKMSKFRSVHWALLLRVLTSEHRSWTSQRLQQ 102

Human   549 ----------------QLLAGCHDN------QAMLDRYRILITKDSAQESVITRDIHRTFPAHDY 591
                            ||...|:|:      |::.::|    ..|....:||.:|:.||||..|:
  Fly   103 RVRYDKFRADYVRNPHQLAVDCNDDPLSQSTQSVWNQY----FSDQDLFAVIRQDVVRTFPGVDF 163

Human   592 FKDTGGDGQESLYKICKAYSVYDEDIGYCQG-QSFLAAVLLLHMPEEQA---FCVLVKIMYDYGL 652
            |:..  ..|.::..|...|:.....:.|.|| ...||.::.:...:.|:   |..|.|...:..|
  Fly   164 FRKP--LVQNAMVNILFYYAREHPYMCYRQGMHEILAPIIFVVYSDHQSLLHFSELAKTDINPTL 226

Human   653 RDLYRNNF--EDLHCKFYQL--------------------------------------------- 670
            .|:....:  .|.:..|.:|
  Fly   227 LDVLDPAYLEADTYSLFSRLMASVESYYRVSNLVSTPGGHIEQRAESPGDNETSTEAEVIGQLNF 291

Human   671 --ERLMQEQLPDLHSHFSDLNLEAHMYASQWFLTLFTAKFPLCMVFHIIDLLL--------CEGL 725
              ::::.:|...||.:...:.:..|::..:|...||..:|.|      :||||        .:..
  Fly   292 IRDKILAKQDQHLHHYLQKMEIPLHIFGIRWLRLLFGREFML------LDLLLLWDAIFADSDRF 350

Human   726 NIIFHVALALLKTSKEDLLQADFEGALKFFR-------VQL----------PKRYRAEENARRLM 773
            ::..::.:|:|...::.||.:|:..:|.:..       |.|          ||::....||...:
  Fly   351 DLPNYILVAMLVHIRDKLLLSDYTTSLTYLMRYPNNVDVHLVLRHALFMLNPKQFEYPPNAFTCV 415

Human   774 EQA-----CNIKVPTKKLKKYEKEYQTMRESQLQQEDPMDRYKRENRRLQEASMRLEQENDDLAH 833
            ..|     .::..|..:..:...|..:|..|..|.:..:...:..|.....|..:|:.
  Fly   416 SFANSSADKDVPPPAGQRPRTNSENSSMATSGSQIDRQITFMQERNAADSSALAKLQD------- 473

Human   834 ELVTSKIALRNDLDQAEDKADVLNKELLLTKQRLVETEEEKRKQEEETAQLKEVFRKQLEKAEYE 898
               |.::|:...|   |:..::|..||   |......:..:.|.:...:.::....||...:| |
  Fly   474 ---THRVAMDGYL---ENSPELLRLEL---KNAQTVIKIARSKLQSYLSTVRHHVGKQANGSE-E 528

Human   899 IKKTTAIIAEYKQICSQLSTR----LEKQQAASKEELEVVKGKMMAC-----KHCSDIFSKEGAL 954
            :.:|...|.|   :||.|..:    |.::.|...:.||..:.|.:..     |..:.........
  Fly   529 LGRTLDGIEE---LCSFLDVKFMFPLHQRSAPIDQALEANEQKQLNTVSKPPKPTASSTPANAPA 590

Human   955 KLAATGREDQGIETDDE---KDSLKK---QLREMEL 984
            .|:|||    |.:..:.   ..|:::   :|||:||
  Fly   591 ALSATG----GYQMPENAFMHSSMRRLLGELREIEL 622

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
RABGAP1L	NP_001353375.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..52
		PTB_Rab6GAP	129..257	CDD:269922
		DUF3694	290..421	CDD:463599
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	461..503
		TBC	535..744	CDD:214540	54/314 (17%)
		Smc	<794..>1020	CDD:440809	42/206 (20%)
TBC1D5	NP_731780.1	TBC	<150..369	CDD:214540	40/226 (18%)