DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment RBM19 and MRD1

DIOPT Version :9

Sequence 1:	NP_001140170.1	Gene:	RBM19 / 9904	HGNCID:	29098	Length:	960	Species:	Homo sapiens
Sequence 2:	NP_015437.1	Gene:	MRD1 / 856228	SGDID:	S000006316	Length:	887	Species:	Saccharomyces cerevisiae

Alignment Length:	1019	Identity:	315/1019 - (30%)
Similarity:	498/1019 - (48%)	Gaps:	200/1019 - (19%)

- Green bases have known domain annotations that are detailed below.

Human     1 MSRLIVKNLPNGMKEERFRQLF-----------AAFGT----LTDCSLKFTKDGKFRKFGFIGFK 50
            |||:|||.||..:.::..|:.|           |..|:    :||..:...::|:.|:|||||::
Yeast     1 MSRIIVKGLPVYLTDDNLREHFTKRLRQKHSHQAVNGSGPDLITDVKILRDRNGESRRFGFIGYR 65

Human    51 SEEEAQKAQKHFNKSFIDTSRITVEFCKSFGDPAKPRAWSKHAQKPSQPKQPPKDSTTPEIKK-- 113
            :||:|..|.::||.|||:||:|.|...|||.||..|              ||.|:.....:|:
Yeast    66 NEEDAFDAVEYFNGSFINTSKIEVSMAKSFADPRVP--------------QPMKEKRREALKRFR 116

Human   114 ----------DEKKKKV-----AGQLEKLKEDTEFQEFLSVHQRRAQAATWANDGLDAEPSKGKS 163
                      :.|||||     :...::::::.:.|||:...:..:|..:|...|:|
Yeast   117 EKEEKLLQEENRKKKKVDENKHSNIDDEIRKNKQLQEFMETMKPSSQVTSWEKVGID-------- 173

Human   164 KPASDYLNFDSDSGQESEEEGAGEDLEEEASLEPKAAVQKELSDMDYLKSKMVKAGSSSSSEEEE 228
                          :..|:|....: ||::|::..:.:...|:    ||             ||.
Yeast   174 --------------KSIEDEKLKRE-EEDSSVQGNSLLAHALA----LK-------------EEN 206

Human   229 SEDEAVHCDEGSEAEEEDSSATPVLQERDSKGAGQEQGM--PAGKKRPPEARAETEKPANQKEPT 291
            ::|||.:....:|:::| .||....::.|.:.||:|:.|  .:..|.........:..:::||
Yeast   207 NKDEAPNLVIENESDDE-YSALNRNRDEDQEDAGEEEKMISISNLKDTDIGLVNDDANSDEKE-- 268

Human   292 TCHTVKLRGAPFNVTEKNVMEFLAPLKPVAIRIVRNAHGNKTGYIFVDFSNEEEVKQALKCNREY 356
               ..|.|    |:.:...:..|...|...:||.               .:|.|.::
Yeast   269 ---NEKRR----NLAQDEKVSDLDWFKQRRVRIK---------------ESEAETRE-------- 303

Human   357 MGGRYIEVFREKNVPTTKGAPKNTTKSWQGRILGENEEEEDLA-----ESGRLFVRNLPYTSTEE 416
                     :..:..|.:....:|.|..|.......:.:|:||     ::||||:||:.|||.||
Yeast   304 ---------KSSSYATEQNESLDTKKEEQPERAVPQKTDEELAIEKINQTGRLFLRNILYTSKEE 359

Human   417 DLEKLFSKYGPLSELHYPIDSLTKKPKGFAFITFMFPEHAVKAYSEVDGQVFQGRMLHVLPSTIK 481
            |..||||.:|.|.|:|..:|:.|.:.||||::.|...::||.||.|:|.|:||||:||:||...|
Yeast   360 DFRKLFSPFGELEEVHVALDTRTGQSKGFAYVLFKDSKNAVNAYVELDKQIFQGRLLHILPGEEK 424

Human   482 KEASEDASALGSSSYKKKKEAQDK-ANSASSHNWNTLFMGPNAVADAIAQKYNATKSQVFDHETK 545
            |....|...|.:...||:||.:.| |.|..:.:||:|:|..:||..::|.|....|||:.|.|..
Yeast   425 KSHRLDEFDLKNMPLKKQKELKRKAAASRQTFSWNSLYMNQDAVLGSVAAKLGLEKSQLIDAENS 489

Human   546 GSVAVRVALGETQLVQEVRRFLIDNGVSLDSFSQ--AAAERSKTVILVKNLPAGTLAAQLQETFG 608
            .| ||:.||.|..::.:||::....||.|..|||  :..:|...||||||.|.||...:|.|.|.
Yeast   490 SS-AVKQALAEAHVIGDVRKYFESKGVDLTKFSQLKSTNQRDDKVILVKNFPFGTTREELGEMFL 553

Human   609 HFGSLGRVLLPEGGITAIVEFLEPLEARKAFRHLAYSKFHHVPLYLEWAPVGVFSSTAPQKKKLQ 673
            .:|.|.|:|:|..|..|||:|.:...||.||..|:|.:|....:|||..|              :
Yeast   554 PYGKLERLLMPPAGTIAIVQFRDTTSARAAFTKLSYKRFKDGIIYLERGP--------------K 604

Human   674 DTPSEPMEKDPAEPETVPDGETPEDENPTEEGADNSSAKMEEEEEEEE-----EEEESLPGCT-- 731
            |..::|.|.|    :.:.:....|:|||.|. ..:|:..||..::..|     .:|:.:.|.|
Yeast   605 DCFTKPAEAD----DLINNTSAKEEENPVEV-KPSSNDLMEANKDVTEGSSNAHDEDVIDGPTVS 664

Human   732 LFIKNLNFDTTEEKLKEVFS-----KVGTVKSCSISKKKNKAGVLLSMGFGFVEYRKPEQAQKAL 791
            :|||||||.||.:.|.:.|.     .|..||:....|.:.|.   |||||||||:|..|||...:
Yeast   665 IFIKNLNFSTTNQNLTDRFKVFTGFVVAQVKTKPDPKHQGKT---LSMGFGFVEFRTKEQANAVI 726

Human   792 KQLQGHVVDGHKLEVRISERATKPA---VTLARKKQVPRKQTTSKILVRNIPFQAHSREIRELFS 853
            ..:.|.|:||||:::::|.|....:   .|.:.||       :.||:|:|:||:|..:::.|||:
Yeast   727 AAMDGTVIDGHKIQLKLSHRQASQSGNTKTKSNKK-------SGKIIVKNLPFEATRKDVFELFN 784

Human   854 TFGELKTVRLPKKMTGTGTHRGFGFVDFLTKQDAKRAFNALCHSTHLYGRRLVLEWADSEV--TL 916
            :||:||:||:|||...:.  |||.||:||..::|:.|.:.| |..||.|||||:::|:.:.  ..
Yeast   785 SFGQLKSVRVPKKFDKSA--RGFAFVEFLLPKEAENAMDQL-HGVHLLGRRLVMQYAEEDAVDAE 846

Human   917 QALRRKTAAHFHEPPKKKRSVVLDEILEQLEGS-----DSDSEE 955
            :.:.|.|       .|.::.|..:|:.....|.     |.|.||
Yeast   847 EEIARMT-------KKVRKQVATNEMAALRNGGGRKKLDVDDEE 883

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RBM19	NP_001140170.1	RRM	<2..>104	CDD:223796	41/116 (35%)
		RRM1_RBM19	2..77	CDD:241008	33/89 (37%)
		RRM_u2	82..286	CDD:293257	42/222 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	85..119		7/45 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	149..294		28/146 (19%)
		RRM	<270..450	CDD:223796	45/184 (24%)
		RRM2_RMB19	294..365	CDD:240946	9/70 (13%)
		RRM	<400..>500	CDD:223796	48/99 (48%)
		RRM3_RBM19	400..478	CDD:241011	41/77 (53%)
		RRM	477..801	CDD:223796	120/338 (36%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	491..513		8/22 (36%)
		RRM4_RBM19	587..658	CDD:241013	32/70 (46%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	667..729		14/66 (21%)
		RRM5_RBM19_like	730..809	CDD:240764	36/85 (42%)
		RRM6_RBM19	832..910	CDD:241015	37/77 (48%)
MRD1	NP_015437.1	RRM4_MRD1	663..746	CDD:409758	36/85 (42%)
		RRM5_MRD1	763..837	CDD:241014	37/76 (49%)
		RRM1_RBM19_MRD1	2..92	CDD:409754	33/89 (37%)
		RRM	222..612	CDD:223796	143/446 (32%)
		RRM2_MRD1	343..421	CDD:409982	41/77 (53%)
		RRM3_MRD1	532..603	CDD:241012	32/70 (46%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C159048059
Domainoid	1	1.000	80	1.000	Domainoid score	I2249
eggNOG	1	0.900	-	-		E1_KOG0110
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H7158
Inparanoid	1	1.050	399	1.000	Inparanoid score	I365
Isobase	1	0.950	-	0	Normalized mean entropy	S1863
OMA	1	1.010	-	-		QHG54158
OrthoFinder	1	1.000	-	-		FOG0003677
OrthoInspector	1	1.000	-	-		oto144843
orthoMCL	1	0.900	-	-		OOG6_102169
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R745
SonicParanoid	1	1.000	-	-		X3041
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	15	14.640