DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment RBM19 and rbm19

DIOPT Version :9

Sequence 1:	NP_001140170.1	Gene:	RBM19 / 9904	HGNCID:	29098	Length:	960	Species:	Homo sapiens
Sequence 2:	NP_944597.2	Gene:	rbm19 / 387255	ZFINID:	ZDB-GENE-031125-3	Length:	927	Species:	Danio rerio

Alignment Length:	984	Identity:	583/984 - (59%)
Similarity:	713/984 - (72%)	Gaps:	87/984 - (8%)

- Green bases have known domain annotations that are detailed below.

Human     1 MSRLIVKNLPNGMKEERFRQLFAAFGTLTDCSLKFTKDGKFRKFGFIGFKSEEEAQKAQKHFNKS 65
            |||||||||||||||:|||::||.|||||||:||||||||||||||:|||:||:||||.||||||
Zfish     1 MSRLIVKNLPNGMKEDRFRKMFADFGTLTDCALKFTKDGKFRKFGFVGFKTEEDAQKALKHFNKS 65

Human    66 FIDTSRITVEFCKSFGDPAKPRAWSKHAQKPSQPKQPPKDSTTPEIKKDEKK-KKVAGQLEKLKE 129
            |:||||:|||.|..||||.|.|.||||.::||..|...:..|..:.:|::|| ||:...|..|::
Zfish    66 FVDTSRVTVELCTDFGDPNKARPWSKHTRQPSSKKDTEEKKTHEQGEKEKKKPKKILNVLGDLEK 130

Human   130 DTEFQEFLSVHQRRAQAATWANDGLDA-------EPSKGKSKPAS---DYLNFDSDSGQESEEEG 184
            |..|||||:|||:|.|..|||||.::|       |..|.|.:.|:   ||||||||..:||.::|
Zfish   131 DESFQEFLAVHQKRGQVPTWANDTVEATAVRPEMEKKKEKKQKAAVEDDYLNFDSDESEESSDDG 195

Human   185 AGEDLEEEASLEPKAAVQKELSDMDYLKSKMV--------KAGSSSSSEEEESEDEAVHCDEGSE 241
            .....||:.....|.|::..|||||||:||||        |...||:|..:|:|:     |||.|
Zfish   196 EDAADEEDKQDNEKEALKTGLSDMDYLRSKMVEKSDMLDEKDDDSSASAADENEE-----DEGKE 255

Human   242 AEEEDSSATPVLQERDSKGAGQEQGMPAGKKRPPEARAETEKPANQK------EPTTCHTVKLRG 300
            .||.      ::|..||   ..|.|               ||.::||      ||||..||||||
Zfish   256 EEES------IVQHADS---AYESG---------------EKTSSQKSTRPAIEPTTEFTVKLRG 296

Human   301 APFNVTEKNVMEFLAPLKPVAIRIVRNAHGNKTGYIFVDFSNEEEVKQALKCNREYMGGRYIEVF 365
            |||||.|:.|.||:.||||||||..:|:.|..:||::||..:|.||::||:.:::||||||||||
Zfish   297 APFNVKEQQVKEFMMPLKPVAIRFAKNSDGRNSGYVYVDLRSEAEVERALRLDKDYMGGRYIEVF 361

Human   366 REKNVPTTKGAPKNT--TKSWQGRILGENEEEEDLAESGRLFVRNLPYTSTEEDLEKLFSKYGPL 428
            |..|....:.:.|.:  .|::. |.|.::|||||:|||||||:||:|||.|||||:::|||:|||
Zfish   362 RANNFKNDRRSAKRSEMEKNFV-RELKDDEEEEDVAESGRLFIRNMPYTCTEEDLKEVFSKHGPL 425

Human   429 SELHYPIDSLTKKPKGFAFITFMFPEHAVKAYSEVDGQVFQGRMLHVLPSTIKKE-ASEDASALG 492
            ||:.:||||||||||||||:|:|.||:||.|.:::||..||||:|||:.|.:||| |.:...|.|
Zfish   426 SEVLFPIDSLTKKPKGFAFVTYMIPENAVSALAQLDGHTFQGRVLHVMASRLKKEKADQGPDAPG 490

Human   493 SSSYKKKKEAQDKANSASSHNWNTLFMGPNAVADAIAQKYNATKSQVFDHETKGSVAVRVALGET 557
            |||||:||:|:|||.|.|||||||||:|.:|||||||:|||.|||||.|||:.||:|||:|||||
Zfish   491 SSSYKRKKDAKDKAASGSSHNWNTLFLGTSAVADAIAEKYNTTKSQVLDHESDGSLAVRMALGET 555

Human   558 QLVQEVRRFLIDNGVSLDSFSQAAAERSKTVILVKNLPAGTLAAQLQETFGHFGSLGRVLLPEGG 622
            |:|||.|:||:||||||||||||:.||||.||||||||:|...|.|:..|...|||||||||..|
Zfish   556 QIVQETRQFLLDNGVSLDSFSQASGERSKCVILVKNLPSGVQVADLEALFSPHGSLGRVLLPPSG 620

Human   623 ITAIVEFLEPLEARKAFRHLAYSKFHHVPLYLEWAPVGVFSSTAPQKKKLQDTPSEPMEKDPAEP 687
            :|||||||||.||::||..|||:||.|||||||||||.||:           |||.|
Zfish   621 LTAIVEFLEPTEAKRAFMKLAYTKFQHVPLYLEWAPVAVFT-----------TPSAP-------- 666

Human   688 ETVPDGETPEDENPTEEGADNSSAKMEEEEEEEEEEEESLPGCTLFIKNLNFDTTEEKLKEVFSK 752
                   .||.:...:....|.|.:.|||||||||:::.|||.|||||||||.|:||.|::.|||
Zfish   667 -------RPEPQTKEKSAVKNDSVQNEEEEEEEEEDDQILPGSTLFIKNLNFITSEETLQKTFSK 724

Human   753 VGTVKSCSISKKKNKAGVLLSMGFGFVEYRKPEQAQKALKQLQGHVVDGHKLEVRISERATKPAV 817
            .|.||||:||||::|||.|||||:|||:|:.||.||||::|||...||.|:|||:||||..|..|
Zfish   725 CGVVKSCTISKKRDKAGKLLSMGYGFVQYKTPEAAQKAMRQLQHCTVDEHQLEVKISEREVKSGV 789

Human   818 TLA-RKKQVPRKQTTSKILVRNIPFQAHSREIRELFSTFGELKTVRLPKKMTGTGTHRGFGFVDF 881
            ..| ||||..|||||||||||||||||..:|:||||.|||||||||||||..| |:||||||:||
Zfish   790 AQAKRKKQTARKQTTSKILVRNIPFQATVKELRELFCTFGELKTVRLPKKGIG-GSHRGFGFIDF 853

Human   882 LTKQDAKRAFNALCHSTHLYGRRLVLEWADSEVTLQALRRKTAAHFHEPPKKKRSV-VLDEILEQ 945
            |||||||:||:|||||||||||||||||||:|.|:..||||||.|||:.|||||.. ||:.||||
Zfish   854 LTKQDAKKAFSALCHSTHLYGRRLVLEWADAEETVDDLRRKTAQHFHDAPKKKRKAEVLEGILEQ 918

Human   946 LEGSDSDSE 954
            :|..|.|.|
Zfish   919 MEVGDGDGE 927

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RBM19	NP_001140170.1	RRM	<2..>104	CDD:223796	77/101 (76%)
		RRM1_RBM19	2..77	CDD:241008	63/74 (85%)
		RRM_u2	82..286	CDD:293257	85/222 (38%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	85..119		13/34 (38%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	149..294		60/168 (36%)
		RRM	<270..450	CDD:223796	102/187 (55%)
		RRM2_RMB19	294..365	CDD:240946	42/70 (60%)
		RRM	<400..>500	CDD:223796	66/100 (66%)
		RRM3_RBM19	400..478	CDD:241011	54/77 (70%)
		RRM	477..801	CDD:223796	200/324 (62%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	491..513		15/21 (71%)
		RRM4_RBM19	587..658	CDD:241013	48/70 (69%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	667..729		18/61 (30%)
		RRM5_RBM19_like	730..809	CDD:240764	52/78 (67%)
		RRM6_RBM19	832..910	CDD:241015	65/77 (84%)
rbm19	NP_944597.2	RRM	<2..>108	CDD:223796	77/105 (73%)
		RRM1_RBM19	2..77	CDD:241008	63/74 (85%)
		RRM_u2	129..>235	CDD:293257	47/105 (45%)
		RRM2_RMB19	290..361	CDD:240946	42/70 (60%)
		RRM	<356..>492	CDD:223796	79/136 (58%)
		RRM3_RBM19	397..475	CDD:241011	54/77 (70%)
		RRM4_RBM19	585..656	CDD:241013	48/70 (69%)
		RRM5_RBM19_like	702..781	CDD:240764	52/78 (67%)
		RRM6_RBM19	805..882	CDD:241015	65/77 (84%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C194330363
Domainoid	1	1.000	155	1.000	Domainoid score	I17287
eggNOG	1	0.900	-	-		E1_KOG0110
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H7158
Inparanoid	1	1.050	1080	1.000	Inparanoid score	I1974
NCBI	1	1.000	-	-
OMA	1	1.010	-	-		QHG54158
OrthoDB	1	1.010	-	-		D1428854at2759
OrthoFinder	1	1.000	-	-		FOG0003677
OrthoInspector	1	1.000	-	-		oto44002
orthoMCL	1	0.900	-	-		OOG6_102169
Panther	1	1.100	-	-	LDO	PTHR23147
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R745
SonicParanoid	1	1.000	-	-		X3041
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	1	1.500	-	-
	18	18.300