DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment RBM19 and Rbm19

DIOPT Version :9

Sequence 1:	NP_001140170.1	Gene:	RBM19 / 9904	HGNCID:	29098	Length:	960	Species:	Homo sapiens
Sequence 2:	NP_001358888.1	Gene:	Rbm19 / 304512	RGDID:	1308928	Length:	955	Species:	Rattus norvegicus

Alignment Length:	968	Identity:	792/968 - (81%)
Similarity:	857/968 - (88%)	Gaps:	21/968 - (2%)

- Green bases have known domain annotations that are detailed below.

Human     1 MSRLIVKNLPNGMKEERFRQLFAAFGTLTDCSLKFTKDGKFRKFGFIGFKSEEEAQKAQKHFNKS 65
            |||||||||||||||:|||||||||||||||||||||:||||||||||||||||||.|..||::|
  Rat     1 MSRLIVKNLPNGMKEDRFRQLFAAFGTLTDCSLKFTKEGKFRKFGFIGFKSEEEAQAALNHFHRS 65

Human    66 FIDTSRITVEFCKSFGDPAKPRAWSKHAQKPSQPKQPPKDSTTPEIKKDEKKKKVAGQLEKLKED 130
            ||||||||||||||||||:||||||||||||||||||.:||...:.|||:|||||...|||||||
  Rat    66 FIDTSRITVEFCKSFGDPSKPRAWSKHAQKPSQPKQPSQDSIPSDTKKDKKKKKVPSDLEKLKED 130

Human   131 TEFQEFLSVHQRRAQAATWANDGLDAEPSKGKSKPASDYLNFD----SDSGQESEEEGAGEDLEE 191
            .|||||||:||:|.|.||||||.|:||..|.|:||:|||||||    ||||||||||.||||.||
  Rat   131 AEFQEFLSIHQKRTQVATWANDALEAELPKAKAKPSSDYLNFDSDSNSDSGQESEEEPAGEDGEE 195

Human   192 EASLEPKAAVQKELSDMDYLKSKMVKAGSSSSSEE-EESEDEAVHCDEGSEAEEEDSSATPVLQE 255
            |..|:||||||||||||||||||||:|..||..|: |:||||||:|:||||||||:.|.|...|:
  Rat   196 EQGLQPKAAVQKELSDMDYLKSKMVRAEVSSEDEDKEDSEDEAVNCEEGSEAEEEEGSPTCPAQQ 260

Human   256 RDSKGAGQEQGMPAGKKRPPEARAETEKPANQKEPTTCHTVKLRGAPFNVTEKNVMEFLAPLKPV 320
                 ||..:|...|..||.||..:.||||:||||||.:||||||||||||||||:|||||||||
  Rat   261 -----AGVNRGAVLGSLRPQEAAGKVEKPASQKEPTTPYTVKLRGAPFNVTEKNVLEFLAPLKPV 320

Human   321 AIRIVRNAHGNKTGYIFVDFSNEEEVKQALKCNREYMGGRYIEVFREKNVPTTKGAPKNTTKSWQ 385
            |||||||||||||||:|||.|:|||||:||||||||||||||||||||.....:||||:::..||
  Rat   321 AIRIVRNAHGNKTGYVFVDLSSEEEVKKALKCNREYMGGRYIEVFREKQASAARGAPKSSSAPWQ 385

Human   386 GRILGENEEEEDLAESGRLFVRNLPYTSTEEDLEKLFSKYGPLSELHYPIDSLTKKPKGFAFITF 450
            ||.|||:|||||||:|||||||||.|||:|||||||||.|||||||||||||||||||||||:||
  Rat   386 GRTLGEHEEEEDLADSGRLFVRNLSYTSSEEDLEKLFSAYGPLSELHYPIDSLTKKPKGFAFVTF 450

Human   451 MFPEHAVKAYSEVDGQVFQGRMLHVLPSTIKKEASEDASALGSSSYKKKKEAQDKANSASSHNWN 515
            ||||||||||:|||||||||||||||||||||||:::|:|.| |||||||||.|||||:||||||
  Rat   451 MFPEHAVKAYAEVDGQVFQGRMLHVLPSTIKKEANQEANAPG-SSYKKKKEAMDKANSSSSHNWN 514

Human   516 TLFMGPNAVADAIAQKYNATKSQVFDHETKGSVAVRVALGETQLVQEVRRFLIDNGVSLDSFSQA 580
            ||||||||||||||||||||||||||||||||||||:||||||||||||.|||||||.|||||||
  Rat   515 TLFMGPNAVADAIAQKYNATKSQVFDHETKGSVAVRMALGETQLVQEVRSFLIDNGVCLDSFSQA 579

Human   581 AAERSKTVILVKNLPAGTLAAQLQETFGHFGSLGRVLLPEGGITAIVEFLEPLEARKAFRHLAYS 645
            ||||||||||.||||||||||:|||.|..||||||||||||||||||||||||||||||||||||
  Rat   580 AAERSKTVILAKNLPAGTLAAELQEIFSRFGSLGRVLLPEGGITAIVEFLEPLEARKAFRHLAYS 644

Human   646 KFHHVPLYLEWAPVGVFSSTAPQKKKLQDTPSEPMEKDPAEPETVPDGETPEDENPTEEGADNSS 710
            |||||||||||||:|||.: |||||..|  |.:|.:|..||.|||.:   ||.|....|||:.|.
  Rat   645 KFHHVPLYLEWAPIGVFGA-APQKKDSQ--PEQPAQKAEAEQETVLN---PEGEKALVEGAEASM 703

Human   711 AKM--EEEEEEEEEEEESLPGCTLFIKNLNFDTTEEKLKEVFSKVGTVKSCSISKKKNKAGVLLS 773
            .||  |||||||||||||:||||||||||||:||||.||||||:||.||||:|||||:|||||||
  Rat   704 GKMEEEEEEEEEEEEEESIPGCTLFIKNLNFNTTEETLKEVFSRVGAVKSCTISKKKSKAGVLLS 768

Human   774 MGFGFVEYRKPEQAQKALKQLQGHVVDGHKLEVRISERATKPAVTLARKKQVPRKQTTSKILVRN 838
            ||||||||:||||||||||:||||:||||||||||||||||||:|..||||||:|||||||||||
  Rat   769 MGFGFVEYKKPEQAQKALKRLQGHIVDGHKLEVRISERATKPALTSTRKKQVPKKQTTSKILVRN 833

Human   839 IPFQAHSREIRELFSTFGELKTVRLPKKMTGTGTHRGFGFVDFLTKQDAKRAFNALCHSTHLYGR 903
            |||||:.||||||||||||||||||||||||||.|||||||||:||||||:||||||||||||||
  Rat   834 IPFQANQREIRELFSTFGELKTVRLPKKMTGTGAHRGFGFVDFITKQDAKKAFNALCHSTHLYGR 898

Human   904 RLVLEWADSEVTLQALRRKTAAHFHEPPKKKRSVVLDEILEQLE-GSDSDSEEQTLQL 960
            ||||||||||||:||||||||.||.||||||||.|||.|||||| |.|||||| ||||
  Rat   899 RLVLEWADSEVTVQALRRKTAKHFQEPPKKKRSAVLDGILEQLEDGDDSDSEE-TLQL 955

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RBM19	NP_001140170.1	RRM	<2..>104	CDD:223796	93/101 (92%)
		RRM1_RBM19	2..77	CDD:241008	67/74 (91%)
		RRM_u2	82..286	CDD:293257	140/208 (67%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	85..119		25/33 (76%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	149..294		97/149 (65%)
		RRM	<270..450	CDD:223796	146/179 (82%)
		RRM2_RMB19	294..365	CDD:240946	64/70 (91%)
		RRM	<400..>500	CDD:223796	87/99 (88%)
		RRM3_RBM19	400..478	CDD:241011	71/77 (92%)
		RRM	477..801	CDD:223796	268/325 (82%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	491..513		17/21 (81%)
		RRM4_RBM19	587..658	CDD:241013	65/70 (93%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	667..729		35/63 (56%)
		RRM5_RBM19_like	730..809	CDD:240764	69/78 (88%)
		RRM6_RBM19	832..910	CDD:241015	72/77 (94%)
Rbm19	NP_001358888.1	RRM	<2..184	CDD:223796	146/181 (81%)
		RRM1_RBM19	2..77	CDD:241008	67/74 (91%)
		RRM2_RMB19	294..365	CDD:240946	64/70 (91%)
		RRM3_RBM19	400..478	CDD:241011	71/77 (92%)
		RRM4_RBM19	586..657	CDD:241013	65/70 (93%)
		RRM5_RBM19_like	725..804	CDD:240764	69/78 (88%)
		RRM6_RBM19	827..905	CDD:241015	72/77 (94%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C83683578
Domainoid	1	1.000	396	1.000	Domainoid score	I10942
eggNOG	0	0.000	Not matched by this tool.
HGNC	1	1.500	-	-
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H7158
Inparanoid	1	1.050	1535	1.000	Inparanoid score	I2608
NCBI	1	1.000	-	-
OMA	1	1.010	-	-		QHG54158
OrthoDB	1	1.010	-	-		D1428854at2759
OrthoFinder	1	1.000	-	-		FOG0003677
OrthoInspector	1	1.000	-	-		oto131704
orthoMCL	1	0.900	-	-		OOG6_102169
Panther	1	1.100	-	-	LDO	PTHR23147
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X3041
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	16	16.410