Protein Alignment SV2A and CG31103

DIOPT Version :9

• Sequence 1: NP_001315603.1
• Gene: SV2A / 9900
• HGNCID: 20566
• Length: 742
• Species: Homo sapiens
• Sequence 2: NP_001097914.1
• Gene: CG31103 / 43030
• FlyBaseID: FBgn0051103
• Length: 506
• Species: Drosophila melanogaster
• Alignment Length: 583
• Identity: 123/583 - (21%)
• Similarity: 218/583 - (37%)
• Gaps: 150/583 - (25%)

Human   152 YEAILRECGHGRFQWTLYFVLGLALMADGVEVFVVGFVLPSAEKDMCLSDSNKGMLGLIVYLGMM 216
            |:.:|.:.|:|:.||.|..|.||..:........:..::.:::.:...:.:.||::......|:.
  Fly    17 YDMVLEKIGYGKTQWVLLLVSGLLTITSVAAQQAMSIIVIASQCEFETTQAEKGVMMAASVTGIF 81

Human   217 VGAFLWGGLADRLGRRQCLLISLSVNSVFAFFSSFVQGYGTFLFCRLLSGVGIGGSIPIVFSYFS 281
            :..::||.::|.:|||:.||.....::...|...||.....|....||.|:.:|.....:::|.|
  Fly    82 LSTYIWGYISDDIGRRRVLLYGNFASNALQFVLMFVTSVWLFNIINLLVGISVGAVSAALYAYLS 146

Human   282 EFLAQEKRGEHLSWLCMFWMIGGVYAAAMAWAIIPHYGWSFQMGSAYQFHSWRVFVLVCAFPSVF 346
            ||.....|...:::..||..:..:|..|.||.::.. .|:..||. :.|..||:.:||...|...
  Fly   147 EFNIPRHRAVAINYSTMFVSVTAIYVPATAWLVLSS-NWAITMGD-FVFRPWRLLLLVSLLPGFI 209

Human   347 AIGALTTQPESPRFFLENGKHDEAWMVLKQVHDTNMRAKGHPERVFSVTHIKTIHQEDELIEIQS 411
            ....|...||||:|.|...|::||...:..:...| |.|. .::|.|.... |:..||.:.|
  Fly   210 GGLILLYYPESPKFLLSQEKNNEAIEAVAWISKFN-RGKS-IQQVLSCDEF-TLKSEDPVGE--- 268

Human   412 DTGTWYQRWGVRALSLGGQVWG---------------------NFLSCFGPEYRRITLMMMGVWF 455
                          :|.|:..|                     ||:.|        .|.:.|
  Fly   269 --------------NLLGESQGCGILSKICRATIPLFHKPHGFNFILC--------NLALFG--- 308

Human   456 TMSFSYYGLTVWFPDMIRHLQAVDYASRTKVFPGERVEHVTFNFTLENQIHRGGQYFNDKFIGLR 520
             |.||..|:.:|||:::......:..|.|..                            :.:.:.
  Fly   309 -MFFSSNGMQLWFPEIVNRSSGAENNSSTVC----------------------------EILSVP 344

Human   521 LKSVSFEDSLFEECYFEDVTSSNTFFRNCTFINTVFYNTDLFEYKFVNSRLINSTFLHNKEGCPL 585
            ::..:..::|  :|  .|..||.|:..|.
  Fly   345 VEQPNVTETL--DC--TDPISSKTYIDNL------------------------------------ 369

Human   586 DVTGTGEGAYMVYFVSFLGTLAVLPGNIVSALLMDKIGRLRMLAGSSVMSCVSCFFLSFGNSESA 650
             |.|                .|.|.|..:..|:::.:||..:|..:..::.:|...|.|..|.:.
  Fly   370 -VVG----------------FAFLIGFSIQGLILNPLGRKNVLLAALAVATLSGVLLHFMESPTG 417

Human   651 MIALLCLF---GGVSIASWNALDVLTVELYPSDKRTTAFGFLNALCKLAAVLGISIFTSFVGI 710
            ::.|.||:   .|:||   :.:....|:|.|:..|:.|..|    |.....|||...|:.:|:
  Fly   418 VLVLFCLYILLPGLSI---SIMIGAIVDLVPTHLRSKAVSF----CMSLGRLGIIAATNLMGV 473

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SV2A	NP_001315603.1	synapt_SV2	1..742	CDD:130366	123/583 (21%)
		Interaction with SYT1. /evidence=ECO:0000250	1..57
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	33..144
CG31103	NP_001097914.1	2A0115	29..475	CDD:273327	119/571 (21%)
		MFS	34..>189	CDD:119392	34/155 (22%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S5294
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D208328at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.870