Protein Alignment UBAP2L and lig

DIOPT Version :10

• Sequence 1: NP_001362541.1
• Gene: UBAP2L / 9898
• HGNCID: 29877
• Length: 1115
• Species: Homo sapiens
• Sequence 2: NP_001260795.1
• Gene: lig / 35771
• FlyBaseID: FBgn0020279
• Length: 1417
• Species: Drosophila melanogaster
• Alignment Length: 1341
• Identity: 347/1341 - (25%)
• Similarity: 517/1341 - (38%)
• Gaps: 370/1341 - (27%)

Human    16 QPQNQNQTQHKQRPQATAEQIRLAQMI-SDHNDADFEEKVKQLIDITGKNQDECVIALHDCNGDV 79
            |..::.....|.:|:||.||:|:||:. |...|....|||..|:.:|.::::|...||::|:.|:
  Fly    50 QDASKTDKPEKAQPKATTEQLRIAQITNSTTEDPQINEKVLLLLTMTQRSEEEVCCALNECDYDL 114

Human    80 NRAINVLLEGNPD--THSWEMVGKKKGVSGQKDGGQTESN-EEGKENRDR---DRDYSRRRGGPP 138
            ..|.|.|:|..|.  ...:|...|.|..:...||...:.: .:|..|.||   .|:.|..|||.
  Fly   115 EAAANFLIEELPQGAFAKYEKKRKNKAANNTADGAAGDGDWADGNGNADRREKSRNRSSNRGGT- 178

Human   139 RRGRGAS-----RGRECMHGALSKPAV---------------------VRGQENGLDGTKSGGPS 177
               ||:|     ||||......::...                     .|||.||  |.:| ||.
  Fly   179 ---RGSSDSRGWRGRETRENERNQRESREPWSGQNAGQDRGDDRANDNYRGQRNG--GGRS-GPG 237

Human   178 GRGTERG---RRGRGRGRGGSGRRGGRFSAQGMGTFNPADYAEPANTDDNYGNSSGNTWNNTGHF 239
            |.|...|   |.|||.||.| ||.||....:|.|....| |......:.|..:.....|:||...
  Fly   238 GGGRGGGFVSRSGRGGGRMG-GRTGGPRGDRGSGGPGGA-YGSGRGGNANEDHHEVELWDNTIAQ 300

Human   240 EPDDGTSAWRTATEEWGTEDWNEDLSETKIFTASNVSSVPLPAENVTITAGQRIDLAVLLGKTPS 304
            ..:....|...|..:|..|::...|.::|:||.||:::  ..|.||....|..:
  Fly   301 NAEKQQQAHDDAWGDWNNEEYEGSLKDSKVFTTSNLAT--QSAANVVSGTGASV----------- 352

Human   305 TMENDSSNLDPSQAPSLAQPLV--------FSNSKQTAISQPASGNTFSHHSMVSMLGKGFGDVG 361
            |....::..:.|..|.|...||        .|:|...|::.||:
  Fly   353 TAVPAAAGTEISAPPGLEHQLVQQGSHLEESSSSGPAAVTPPAT--------------------- 396

Human   362 EAKGGSTTGSQFLEQFKTA--QALAQLAAQHSQSGSTTTSSWDMGSTTQSPSLVQYDLKNPSDSA 424
             ..|.:||.   |.|:..|  ....||.:|.:|||:.|.:|...|....|         .||...
  Fly   397 -LSGSATTP---LLQYSAAVSNPPPQLQSQGTQSGAGTGASAAAGGGAGS---------TPSSFV 448

Human   425 VHSPFTKRQAFTPSSTMMEVFLQEKSPAVATSTAAPPPPSSPLPSK------STSAPQMSPGSSD 483
            ..||.|...|.:.::|:  |...:|...:...| .|..||:.|..:      |.::..:||||..
  Fly   449 SASPDTFSSAASAAATL--VHQAQKQQQLQQQT-TPIKPSATLSVEQSQYFNSLASQGVSPGSVP 510

Human   484 NQSS------SPQPA-------------------------------------QQKLKQQKKKASL 505
            .||:      :|..|                                     |.::::.:.|...
  Fly   511 VQSAPAGYAQNPVAAYSQTSTSVGVSQYPNTYANVFASGTAAGAGTAEQSQQQPQIRRARVKLPP 575

Human   506 TSKIPALAVEMPGS---ADISGLNLQFGALQFGS----EPV------------------LSDYES 545
            .|||||.||||||.   .:|..|::|||||.||:    ||:                  ..||:|
  Fly   576 PSKIPASAVEMPGDNALNNIGYLDVQFGALDFGTDDGFEPLPEKVGSGFSIDGQQQQQQPDDYQS 640

Human   546 --------TPTTSASSSQAPSSL----YTS---------TASESSSTI-------------SSNQ 576
                    |......|||...:|    |||         .:|..::||             .|..
  Fly   641 KSQQQQQVTLAAGLQSSQISDALNAAGYTSRSTSQQQQGVSSAVNATIDQLTKSDPYGQTGGSGN 705

Human   577 SQESGYQS---------------GPIQSTTYTSQNNAQGPLYEQR---STQTRRYPSSISSSPQK 623
            :.::.|||               |...|:||.:..::....|:|:   |.|...|.....|..|.
  Fly   706 AYQNAYQSSGASKTASGFPTTAPGGYSSSTYANVQSSVANSYQQQGYGSYQPSSYQQQAGSGAQS 770

Human   624 DL--------TQAKN----GFSSVQATQLQTTQSV---EGATGS--AVKSDSPSTSSIPPLNETV 671
            ..        |..:|    |.||..:|.:.|:..|   .|:||:  .|...:.:..:....|.:|
  Fly   771 GTGAVSGGGGTATQNIPVGGSSSQNSTSVSTSSGVSSNSGSTGNGGVVSGQTGANQAAVSNNNSV 835

Human   672 SAASLLT--TTNQHSSSL----GGLSHSEEIPNTTTTQHSSTLSTQQNTLSSSTSSGRTSTSTLL 730
            |.:|.::  |....|.::    ||:|.| .:.:.......|..|...|..::|:|:.....:|:.
  Fly   836 SGSSSVSNVTAGVASGNVAGVGGGVSQS-GVSSGVGVPGGSASSVGVNVNNNSSSASSVGAATVA 899

Human   731 HTSVESEANLHSSSSTFSTTSSTVSAPPPVVSVSSSLNSGSSLGLSLG--SNSTVTASTRSSVAT 793
            .|:..:.|.:.:|.:..:|:||..|......:.::...||...|.|.|  .:|:......|...:
  Fly   900 QTATGTTAAVLASLTNKNTSSSNSSGSGGSAATTTGNASGQGAGASTGGVGSSSGAGGAGSGGGS 964

Human   794 TSGKAPPNLPPGVPPLLPNPYIMAPGLLHAYPPQVYGYDDLQMLQTRFP--LDYYSIPFPTPTTP 856
            .||..|.|:.      :.:.||.. ||.: |...||.|::|||:|.|.|  ..||.:.:| |.:.
  Fly   965 GSGLVPTNIQ------MVSQYIQT-GLPY-YQQPVYSYEELQMMQQRVPHVQGYYDLNYP-PASL 1020

Human   857 LTGRDGSLASNPYSG-DLTKFGRGD-ASSPAPATTLAQPQQNQTQTHHTTQQTFLNPALPPGYSY 919
            ..||| :|.|..||. :..:|.|.| .|||....:....||..:..          |.|...|:|
  Fly  1021 GAGRD-NLGSVTYSAMNDGRFARTDNNSSPVGNVSSTMSQQAGSSA----------PMLNVPYAY 1074

Human   920 TSLPYYTGVPGLPSTFQYG-PAVFPVAPTSSKQHGVNVSVNASATPFQQPS---GYGSHGYNT-- 978
                :|.| ..:|.:|||| ||::|..|.::         .||...|.:||   ||||..|:|
  Fly  1075 ----FYGG-NVMPGSFQYGTPAIYPQIPAAN---------TASGQQFPKPSYSAGYGSTSYDTLS 1125

Human   979 ---------GVS---------VTSSN-----TGVPDISGSVYSKTQ------QSFEKQGFHSGTP 1014
                     |.|         .|.||     || .|::.|:|.|..      .|:|||.||||||
  Fly  1126 QTTQDYSKGGYSSSVNQQSKTQTVSNQSQAGTG-SDLTSSMYGKGHVALNKVNSYEKQSFHSGTP 1189

Human  1015 AASFNLPSALGSGGPINPATAA----AYPPAPFMHILTPHQQPHSQILHHHLQQDGQLPYLQMIL 1075
             ..||:|:...:||     |:|    .|.|.|        ...|..::|..:.||
  Fly  1190 -PPFNMPNTQTAGG-----TSAQPYGMYLPMP--------AAGHHNMIHQPIHQD---------- 1230

Human  1076 CCQRQQEEQTGSGQRSQTSSIPQKPQTNKSAYNSYSW-GAN 1115
                    ...:|||.|::|  |.....|..|:...| |.|
  Fly  1231 --------SNSAGQRQQSTS--QSKSAGKQGYSPSYWAGQN 1261

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
UBAP2L	NP_001362541.1	UBA_UBP2_like	50..87	CDD:270463	12/36 (33%)
		DUF3697	507..534	CDD:372135	18/29 (62%)
lig	NP_001260795.1	PRK12678	16..>229	CDD:237171	51/182 (28%)
		UBA_UBP2_like	85..122	CDD:270463	12/36 (33%)
		DUF3697	575..607	CDD:372135	18/31 (58%)