Protein Alignment FIG4 and FIG4

DIOPT Version :10

• Sequence 1: NP_055660.1
• Gene: FIG4 / 9896
• HGNCID: 16873
• Length: 907
• Species: Homo sapiens
• Sequence 2: NP_608841.1
• Gene: FIG4 / 33658
• FlyBaseID: FBgn0031611
• Length: 858
• Species: Drosophila melanogaster
• Alignment Length: 938
• Identity: 383/938 - (40%)
• Similarity: 543/938 - (57%)
• Gaps: 152/938 - (16%)

Human     7 PIISSVQKLVLYETRARYFLVGSNNAETKYRVLKIDRTEPKDLVIIDDRHVYTQQEVRELLGRLD 71
            |:|||:||:||||||||.:||||||.||::|:|.|||.....|.|.::.:.:...|:|..:..|
  Fly    12 PLISSIQKVVLYETRARLYLVGSNNRETRFRLLTIDRLAHNRLSIEENANEFNSLEIRRFVASL- 75

Human    72 LGNRTKMGQKGSSGLFRAVSAFGVVGFVRFLEGYYIVLITKRRKMADIGGHAIYKVEDTNMIYIP 136
                        ||..:..||:||:||||||||||::|:|||:..|.||.|.:|.::||.|:.:
  Fly    76 ------------SGSPKVTSAYGVLGFVRFLEGYYLLLVTKRKCCAHIGRHLVYTIKDTVMVRV- 127

Human   137 ND--SVRVTHPDEARYLRIFQNVDLSSNFYFSYSYDLSHSLQYNLTVLR---MPLEMLKSE---- 192
            |:  |.|..||.|.||.|:|||:||.|||||||||||:.:||||.:..|   ..:::.:.|
  Fly   128 NEVTSQRPPHPHEDRYKRMFQNIDLRSNFYFSYSYDLTRTLQYNESAPRYVGAKVDLDRDEPLPD 192

Human   193 ---MTQNRQESFDIFEDEGLITQGGSGVFGICSEPYMKYVWNGELLDIIKSTVHRDWLLYIIHGF 254
               :|.|..::.:..:            :...|:...::|||..||..::..:.:||||.:.|||
  Fly   193 WNTLTSNVDKAHERVD------------YAFRSDSRKRFVWNAYLLQPMEGIMLKDWLLEVTHGF 245

Human   255 CGQSKLLIYGRPVYVTLIARRSSKFAGTRFLKRGANCEGDVANEVETEQILCDAS-VMSFTAGSY 318
            ..||.:.|:||.|.|.|:|||||:||||||||||||.:||||||||||||:.|.. :.:||
  Fly   246 VSQSCISIFGRHVNVCLVARRSSRFAGTRFLKRGANFQGDVANEVETEQIVSDGQRICAFT---- 306

Human   319 SSYVQVRGSVPLYWSQDISTMMPKPPITLDQADPFAHVAALHFDQMFQRFGSPIIILNLVKEREK 383
                |:|||:|.:||||||.|:|||.|.||..||:|...:|||:::...:|:|:|:|||||:||:
  Fly   307 ----QMRGSIPSHWSQDISKMVPKPQIQLDICDPYAQTPSLHFERLLFHYGAPLIMLNLVKKRER 367

Human   384 RKHERILSEELVAAVTYLNQFLPPEHTIVYIPWDMAKYTKSKLCNVLDRLNVIAESVVKKTGFFV 448
            ||||.|:|:||..::.||||||||.|.:.:|.:|||:.::....||:::|.:.|||:|:.||.|.
  Fly   368 RKHESIISKELEYSIRYLNQFLPPPHRMKHIHFDMARQSRLSGGNVMEQLAIHAESIVQMTGMFF 432

Human   449 NRPDSYCSILRPDEKWNELGGCVIPTGRLQTGILRTNCVDCLDRTNTAQFMVGKCALAYQLYSLG 513
            ....|            |.|        |||||:||||||||||||:|||.:|||||.:||..||
  Fly   433 KAAGS------------EPG--------LQTGIVRTNCVDCLDRTNSAQFAIGKCALGHQLERLG 477

Human   514 LIDKPNLQFDTDAVRLFEELYEDHGDTLSLQYGGSQLVHRVKTYRKIAPWTQHSKDIMQTLSRYY 578
            .:....|:||:|.|.:.|.|||:|||||:|||||||||||:|||||.|||.....|:||||||||
  Fly   478 FVKSAKLEFDSDCVTMLENLYEEHGDTLALQYGGSQLVHRIKTYRKTAPWGSQGSDVMQTLSRYY 542

Human   579 SNAFSDADRQDSINLFLGVFHP--TEGKPHLWELPTDFYLHHKNTMRLLPTRRSYTYWWTPEVIK 641
            ||.|||.::|.|||||||::.|  |:..|.:|||.||:.:|:....|  ...::.|.|     ::
  Fly   543 SNTFSDTEKQHSINLFLGIYKPSLTKQGPPIWELQTDYDMHNAFVPR--ADSKAITDW-----VR 600

Human   642 H---LPLPYDEVICAVNLKKLIVKKFHKYE---EEIDIHNEFFRPYELSSFDDTFCLAMTSSARD 700
            |   ..|||.   || :..||:.:.|..:.   |.||.::.:.:.::.:.|.:.....::..|..
  Fly   601 HKVRACLPYS---CA-DSNKLVKELFRVHSSGLEMIDAYSNYHQSFKWTDFSEHIAFEISQLALR 661

Human   701 FMPKTVGIDPSPF-----TVRK----PDETGKSVLGNKSNREEAVLQRKTAASAPPPPSEEAVSS 756
            :|| |...:.|||     |.||    |..||:|..|:.::..                     ||
  Fly   662 YMP-TFRTNFSPFQRQIQTSRKARQNPSMTGQSSTGSMNSNS---------------------SS 704

Human   757 SSE-DDSGTDREEEGSVSQRSTPVKMTDAGDSAKVTENVVQP-MKELYGINLSDGLSEEDFSIYS 819
            ||| |||.:|.|...|.:::.  ...|::.:.|..|.....| |:|:||..::.. |::..::|.
  Fly   705 SSEGDDSSSDEELSASFAEKE--ANQTESTEPAAATLATGLPSMEEIYGCTINPP-SKQSMAVYK 766

Human   820 RFVQLGQSQHKQDKNSQ-------QPCSRCSDGVIKLTPISAFSQDNIYEVQPPRVDRKSTEIFQ 877
            ::||:|:......:.:|       |..::...| |.|.|:|.:..|:...|:||.|.|||..|
  Fly   767 KYVQMGKLSSGGARPAQTAVAQRDQELAKIMRG-ITLRPLSDYGTDSYLSVRPPVVPRKSLTI-- 828

Human   878 AHIQASQGIMQPLGKEDSSMYREYIRNR 905
                                |.||.|.|
  Fly   829 --------------------YAEYCRTR 836

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
FIG4	NP_055660.1	Syja_N	93..423	CDD:460545	165/342 (48%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	707..788		23/90 (26%)
FIG4	NP_608841.1	Syja_N	85..407	CDD:460545	157/334 (47%)