Protein Alignment FIG4 and fig4

DIOPT Version :10

• Sequence 1: NP_055660.1
• Gene: FIG4 / 9896
• HGNCID: 16873
• Length: 907
• Species: Homo sapiens
• Sequence 2: NP_001018284.3
• Gene: fig4 / 3361401
• PomBaseID: SPAC1093.03
• Length: 832
• Species: Schizosaccharomyces pombe
• Alignment Length: 936
• Identity: 320/936 - (34%)
• Similarity: 461/936 - (49%)
• Gaps: 200/936 - (21%)

Human     7 PIISSVQKLV---LYETRARYFLVGSNNAETKYRVLKIDRTEPKDLVIIDD-RHVYTQQEVRELL 67
            |..:|.:.||   ||:.:..|::|..|...|.:|:|||.::|.:..:.|:: ..:..:|:::..|
pombe     2 PATNSDEPLVKFELYQLKKCYYIVSENATATIFRILKITQSEDELSISIEEAAKILFRQKLQLYL 66

Human    68 GRLDLGNRTKMGQKGSSGLFRAVSAFGVVGFVRFLEGYYIVLITKRRKMADIGGHAIYKVEDTNM 132
            .:|:  |.:..|:     |.....|:.::|..||..|||:.|.|:|:.:|.||||.:|.|:.|..
pombe    67 EKLE--NESADGK-----LILVTKAYAILGLFRFTAGYYLYLCTERKVVAVIGGHNVYHVDKTQF 124

Human   133 IYIPNDSVRVTHPDEARYLRIFQNVDLSSNFYFSYSYDLSHSLQYNLTVLRMPLEMLKSEMTQNR 197
            |.: |.|.|.....|.:.:...:.|||:..||||||||||.::||..|   .|:.         :
pombe   125 IEL-NPSRRHNTSVERKCMSSIEKVDLARTFYFSYSYDLSQTIQYGFT---HPIP---------Q 176

Human   198 QESFDIFEDEGLITQGGSGVFGICSEPYMKYVWNGELLDIIKSTVHRD--WLLYIIHGFCGQSKL 260
            .:..|:|                        |||..:|..|..:|..|  |.:.:||||..|:||
pombe   177 HQVRDMF------------------------VWNWNMLRPILDSVGIDSPWCIPLIHGFVDQAKL 217

Human   261 LIYGRPVYVTLIARRSSKFAGTRFLKRGANCEGDVANEVETEQILCDASVMSFTAGS-------Y 318
            .:||:|:.||||||||..|||.|||:||...:|.||||||||||:.|.|..||...|       |
pombe   218 SVYGKPIIVTLIARRSRHFAGARFLRRGIRDDGYVANEVETEQIVFDGSASSFPISSTTPGIPCY 282

Human   319 SSYVQVRGSVPLYWSQDISTMMPKPPITLDQADPFAHVAALHFDQMFQRFGSPIIILNLVKEREK 383
            :||||.|||:||.|||:.|.:.|||||.:|..|||....|||||::|..:|.|.|:|||||..||
pombe   283 TSYVQHRGSIPLRWSQEFSNITPKPPIGIDFHDPFYASTALHFDRLFGHYGIPCIVLNLVKSSEK 347

Human   384 RKHERILSEELVAAVTYLNQFLPPEHTIVYIPWDMAKYTKSKLCNVLDRLNVIAESVVKKTGFFV 448
            .|.|.:|.:|..:|:.||||||.....|.||.|||:..:|.|: .|...|..:|..:|||||||
pombe   348 VKRESLLLDEFESAIQYLNQFLKDSQKIQYIAWDMSAASKKKV-PVTKTLEQMASDIVKKTGFF- 410

Human   449 NRPDSYCSILRPDEKWNELGGCVIPTGRLQTGILRTNCVDCLDRTNTAQFMVGKCALAYQLYSLG 513
                  |:..|           ..| |..|||::||||||||||||.|||::|||.||.||.:||
pombe   411 ------CTADR-----------FFP-GTFQTGVVRTNCVDCLDRTNAAQFVIGKCVLAAQLRALG 457

Human   514 LIDKPNLQFDTDAVRLFEELYEDHGDTLSLQYGGSQLVHRVKTYRKIAPWTQHSKDIMQTLSRYY 578
            ::|.|.|.:::|||||..|:|..|||.::||||||.||:.:.||||...|:..|:|:::::.|:|
pombe   458 VLDSPQLDYESDAVRLLAEMYHGHGDAIALQYGGSLLVNTLDTYRKNNQWSSTSRDLIESVKRFY 522

Human   579 SNAFSDADRQDSINLFLGVF--H---PTEGKPHLWELPTDFYLHHKNTMRLLPTRRSYTYWWTPE 638
            ||:|.|..||::|:||||.|  |   ...|:..|..|...|    ||...:   ||.|.|||||.
pombe   523 SNSFVDFQRQEAISLFLGNFTVHGKIVVFGEKRLQALTEKF----KNGQLV---RRDYRYWWTPV 580

Human   639 VIKHLPLPYDEVICAVNLKKLIVKKFHKYEEEIDIHNEFFRPYELSSFDDTFCLAMTSS------ 697
            .:.      .|:.|.......|.:|..|:  ..:..:..:.|..:|||.:.....:.|:
pombe   581 YVN------QELRCKNAYCDSIQRKGIKF--PANYFDNVYTPNSISSFSEVLLPNLISTLNFAPL 637

Human   698 ------ARDFMPKT---VGID-PS--PFTVRKPDETGKSVLGNKSNREEAVLQRKTAASAPPPPS 750
                  .:.|:|.:   .||: ||  ||..|:..                             |.
pombe   638 SLIPLLRKSFLPLSYNGFGIEAPSLNPFIPRRNQ-----------------------------PR 673

Human   751 EEAVSSSSEDDSGTDREEEGSVSQRSTPVKMTDAGDSAKVTENVVQPMKELYGINLSDGLSEEDF 815
            :...:|:.|::.  |.:|:....:|.:..|.        :..|..:|:.:.
pombe   674 DMFKTSAEEENE--DEDEDDDKFRRVSLYKW--------LFNNEERPVHKF-------------- 714

Human   816 SIYSRFVQLGQSQHKQDKNSQQPCSRCSDGVIKLTPISAFSQDNIYEVQPPRVDRKSTEIFQAHI 880
             |..|..|:..|...|.::.:||     |..|..|.|      |:|::               |.
pombe   715 -IRKRLHQIPVSNKVQPRDQKQP-----DFKIPNTDI------NVYKI---------------HF 752

Human   881 QAS--QGIMQP---LGKEDSSMYREY 901
            |.:  .|:...   |.|.|.:||..|
pombe   753 QYNNISGLADNYTLLSKHDRAMYNNY 778

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
FIG4	NP_055660.1	Syja_N	93..423	CDD:460545	147/338 (43%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	707..788		14/83 (17%)
fig4	NP_001018284.3	Syja_N	85..387	CDD:460545	147/338 (43%)