Protein Alignment FIG4 and figo-1

DIOPT Version :10

• Sequence 1: NP_055660.1
• Gene: FIG4 / 9896
• HGNCID: 16873
• Length: 907
• Species: Homo sapiens
• Sequence 2: NP_492266.2
• Gene: figo-1 / 172620
• WormBaseID: WBGene00007912
• Length: 905
• Species: Caenorhabditis elegans
• Alignment Length: 959
• Identity: 329/959 - (34%)
• Similarity: 519/959 - (54%)
• Gaps: 127/959 - (13%)

Human    12 VQKLVLYETRARYFLVGSNNAETKYRVLKIDRTEPKDLVIIDDRHVYTQQEVRELLGRLDLG--- 73
            ::|:.:|||::|::::|.::..::|.||||||.:||.|:..:..:.||::|:.|||..:..|
 Worm     5 LRKITVYETKSRFYIIGCDSTGSRYNVLKIDRIDPKALITGEPEYDYTREEILELLATISDGSSV 69

Human    74 ---NRTKMGQKGSSGLF-RAVSAFGVVGFVRFLEGYYIVLITKRRKMADIGGHAIYKVEDTNMIY 134
               :.:|.|.|  |||. ||.:|||::|.|||:||||:::||:...:|.:|.|.:||:.:..||.
 Worm    70 VYRSSSKKGTK--SGLIERATNAFGILGCVRFVEGYYLIIITRAHAVATLGYHPVYKIVEVAMIP 132

Human   135 IPNDSVRVTHPDEARYLRIFQNVDLSSNFYFSYSYDLSHSLQYNLTVLRMPLEMLKSEMTQNRQE 199
            |..|.|. |..:|.:|:::||:||||::||||||||:|.:.|.|         .|:|:...:.|.
 Worm   133 IAMDGVS-TSSEEQKYVKLFQSVDLSTDFYFSYSYDMSRTFQEN---------SLRSDWNNHGQR 187

Human   200 SFDIFEDEGLITQGGSGVFGICSEPYMKYVWNGELLD-IIKSTVHRDWLLYIIHGFCGQSKLLI- 262
            ..:..|                     ::|||..||: :.|:.:...|.:.|:||:..|..:.:
 Worm   188 RLEADE---------------------RFVWNSFLLEPLRKNLISERWFVEIVHGYVRQEYIFLP 231

Human   263 YGRPVYVTLIARRSSKFAGTRFLKRGANCEGDVANEVETEQILCD-ASVMSFTAGSYSSYVQVRG 326
            .|| :.:|:|.|||:|:|||||||||||..|:|||.||||||:.| ||..:...|.:||:||:||
 Worm   232 IGR-ISLTIIGRRSTKYAGTRFLKRGANPTGNVANYVETEQIVWDMASSGNVADGRFSSFVQMRG 295

Human   327 SVPLYWSQDIST--MMPKPPITLDQADPFAHVAALHFDQMFQRFGSPIIILNLVKEREKRKHERI 389
            |||:.||||.||  ::.||.|.:|..:|.|..||.||..:..::|:||:|:||:|..|||:||.:
 Worm   296 SVPMRWSQDPSTRGVVGKPLILIDNHEPHAQTAASHFRDVRNKYGNPIVIMNLIKRNEKRRHEGV 360

Human   390 LSEELVAAVTYLNQFLPPEHTIVYIPWDMAKYTKS----KLCNVLDRLNVIAESVVKKTGFFVNR 450
            |..:.:..:.|||||||.|..:.||.:|:|:..|:    ...|||:.:..::...:.|.|:|.:.
 Worm   361 LHTQFLKNIEYLNQFLPNEEKLCYISFDVARCNKAANSMPSINVLNVMEDLSMKSILKNGWFQSF 425

Human   451 PDSYCSILRPDEKWNELGGCVIPTGR--LQTGILRTNCVDCLDRTNTAQFMVGKCALAYQLYSLG 513
            |.|....:||.|.:..|.......||  :|.||.||||||||||||.|||::.|.||..||.::|
 Worm   426 PLSEALKIRPREAFATLDAHHSKDGRFMIQHGICRTNCVDCLDRTNVAQFVIAKVALGCQLCAMG 490

Human   514 LIDKPNLQFDTDAVRLFEELYEDHGDTLSLQYGGSQLVHRVKTYRKIAPWTQHSKDIMQTLSRYY 578
            ::|:|||...::..||.|:::::||||::|||.||||||.:|||:|.|.:.:..:|:.|||||||
 Worm   491 ILDEPNLTLQSEVCRLLEDMFDEHGDTMALQYAGSQLVHSIKTYKKTAAFQERRRDVFQTLSRYY 555

Human   579 SNAFSDADRQDSINLFLGVFHP--TEGKPHLWELPTDFYLHHKNTMRLLPTRRSYTYWWTPEVIK 641
            ||.|:|.|:|.:||||||||.|  |..| :||:|.:|:.||...::::   ...|..|...|  |
 Worm   556 SNTFNDWDKQMAINLFLGVFRPRITTMK-NLWDLTSDYNLHFPYSLKI---NTDYCAWTLSE--K 614

Human   642 HLP----LPYDEVICA---VNLKKLIVK-------------KFHKYEEEIDIHNEFFRPYELSSF 686
            .|.    |.|||...:   |.::.:.|.             .|..:|:..|.|    |.||.:|.
 Worm   615 ELEDLVFLDYDESENSDGYVEIRSIDVDGRRGSEGSEYRTLLFSSHEDFRDYH----RTYEFTSL 675

Human   687 DDTFCLAMTSSARDFMPKTVGIDPSPFT------VRKPDETGKSVLGNKSNREEAVLQRKTAASA 745
            ||.  :....|..:...:..||:..|.|      :.|..|| |.....|.|:::     |....:
 Worm   676 DDR--IGRLFSIENRAIQVDGINEEPTTHAQFLKLWKTTET-KEKDQKKPNKKD-----KEEKES 732

Human   746 PPPPSEEAVSSSSEDDSGTDRE---------------EEGSVSQRSTPVKMTDAGDSAKVTENVV 795
            .....:|.:|:...|.....:|               ::....:.|||.:.|.....:.::.. :
 Worm   733 DDEDDDEEISTQWSDVVEAQQEWYDLVNAPGNVTTTLQKSPTKRESTPPRNTSRAKRSLLSTG-L 796

Human   796 QPMKELYGINLSDGL--SEEDFSIYSRFVQLGQSQHKQDKNSQQPC----SRCSDGVIKLTPISA 854
            |..|::|.:   |.|  ..|:...|.::.......:.:|....:|.    .:.:..|....| :.
 Worm   797 QFAKDIYHL---DHLKTQPEERRYYEKYAITAFKCNVRDWEKVKPTLLSEFKITSEVEPRRP-TF 857

Human   855 FSQDNIYEVQPPRVDRKSTEIFQAHIQASQGIMQPLGKEDSSMYREYIR 903
            |:.|:.|..:.|.|...|...:   |::|..:......:|...:.:|::
 Worm   858 FTTDDCYRTESPEVSGNSARFY---IKSSHPLTTECSAQDYGFFSKYMQ 903

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
FIG4	NP_055660.1	Syja_N	93..423	CDD:460545	140/334 (42%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	707..788		19/101 (19%)
figo-1	NP_492266.2	Syja_N	91..394	CDD:460545	140/334 (42%)