Protein Alignment FIG4 and fig4a

DIOPT Version :10

• Sequence 1: NP_055660.1
• Gene: FIG4 / 9896
• HGNCID: 16873
• Length: 907
• Species: Homo sapiens
• Sequence 2: XP_073789868.1
• Gene: fig4a / 100334605
• ZFINID: ZDB-GENE-130213-1
• Length: 901
• Species: Danio rerio
• Alignment Length: 907
• Identity: 687/907 - (75%)
• Similarity: 780/907 - (85%)
• Gaps: 9/907 - (0%)

Human     2 PTAAAPIISSVQKLVLYETRARYFLVGSNNAETKYRVLKIDRTEPKDLVIIDDRHVYTQQEVREL 66
            ||||  :|..|||||||||||||||||||||:||:||||||||||:|||||||:|||:|||||||
Zfish     3 PTAA--VIRGVQKLVLYETRARYFLVGSNNAQTKHRVLKIDRTEPRDLVIIDDKHVYSQQEVREL 65

Human    67 LGRLDLGNRTKMGQKGSSGLFRAVSAFGVVGFVRFLEGYYIVLITKRRKMADIGGHAIYKVEDTN 131
            ||||||||||||||||||||.|||||:|:|||||||||||||||||||||||||||:|||:||||
Zfish    66 LGRLDLGNRTKMGQKGSSGLSRAVSAYGIVGFVRFLEGYYIVLITKRRKMADIGGHSIYKIEDTN 130

Human   132 MIYIPNDSVRVTHPDEARYLRIFQNVDLSSNFYFSYSYDLSHSLQYNLTVLRMPLEMLKSEM-TQ 195
            |||||||||||||||||||:|||||||||||||||||||:|||||||||:|:.....::||. ..
Zfish   131 MIYIPNDSVRVTHPDEARYVRIFQNVDLSSNFYFSYSYDVSHSLQYNLTLLQSWSVCVESESGAA 195

Human   196 NRQESFDIFEDEGLITQGGSGVFGICSEPYMKYVWNGELLDIIKSTVHRDWLLYIIHGFCGQSKL 260
            .||::|||||:|||.||   .|.|:..|||.|||||..||:.:|..||.||||||||||||||||
Zfish   196 GRQDTFDIFEEEGLPTQ---VVHGLSHEPYSKYVWNLRLLEKVKEIVHPDWLLYIIHGFCGQSKL 257

Human   261 LIYGRPVYVTLIARRSSKFAGTRFLKRGANCEGDVANEVETEQILCDASVMSFTAGSYSSYVQVR 325
            |||||||||||||||||:||||||||||||||||||||||||||:.||||||.:|||:||.||||
Zfish   258 LIYGRPVYVTLIARRSSRFAGTRFLKRGANCEGDVANEVETEQIIHDASVMSLSAGSFSSCVQVR 322

Human   326 GSVPLYWSQDISTMMPKPPITLDQADPFAHVAALHFDQMFQRFGSPIIILNLVKEREKRKHERIL 390
            |||||:||||||||||||||.||||||||||||||||||.||||||||||||||:|||||||:||
Zfish   323 GSVPLHWSQDISTMMPKPPIRLDQADPFAHVAALHFDQMMQRFGSPIIILNLVKKREKRKHEKIL 387

Human   391 SEELVAAVTYLNQFLPPEHTIVYIPWDMAKYTKSKLCNVLDRLNVIAESVVKKTGFFVNRPDSYC 455
            ||||..|:|.|||||||||.|.||.||||:|||||||||||||::|||||||:|||||||||.||
Zfish   388 SEELYRAITNLNQFLPPEHNIEYIAWDMARYTKSKLCNVLDRLSMIAESVVKRTGFFVNRPDFYC 452

Human   456 SILRPDEKWNELGGCVIPTGRLQTGILRTNCVDCLDRTNTAQFMVGKCALAYQLYSLGLIDKPNL 520
            ..|||||:|.:|||.|.|.||||||:|||||||||||||||||||||||||||||:||:||||.|
Zfish   453 HSLRPDERWGDLGGTVTPNGRLQTGVLRTNCVDCLDRTNTAQFMVGKCALAYQLYALGMIDKPKL 517

Human   521 QFDTDAVRLFEELYEDHGDTLSLQYGGSQLVHRVKTYRKIAPWTQHSKDIMQTLSRYYSNAFSDA 585
            |||||.|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Zfish   518 QFDTDCVRLFEELYEDHGDTLSLQYGGSQLVHRVKTYRKIAPWTQHSKDIMQTLSRYYSNAFSDA 582

Human   586 DRQDSINLFLGVFHPTEGKPHLWELPTDFYLHHKNTMRLLPTRRSYTYWWTPEVIKHLPLPYDEV 650
            ||||:|||||.||.|:|.|||||||||||||||.|||.|...|.|||:|||..|:.:||||:||.
Zfish   583 DRQDAINLFLQVFQPSETKPHLWELPTDFYLHHSNTMTLPHHRHSYTHWWTGGVLTYLPLPFDEA 647

Human   651 ICAVNLKKLIVKKFHKYEEEIDIHNEFFRPYELSSFDDTFCLAMTSSARDFMPKTVGIDPSPFTV 715
            .|..|:||:.||:.::|||..||:.|||:||||::|||||.::||:|||||||||||:|||||||
Zfish   648 QCEENMKKVSVKRVNRYEESTDIYTEFFKPYELTAFDDTFSISMTNSARDFMPKTVGLDPSPFTV 712

Human   716 RKPDETGKSVLGNKSNREEAVLQRKTAASAPPPPSEEAVSSSSEDDSGTDREEEGSVSQRSTPVK 780
            |||||:.|||||:||::|||||||||||||||||:||.:||||||||..|||::.|.||||||::
Zfish   713 RKPDESAKSVLGSKSSKEEAVLQRKTAASAPPPPTEEQISSSSEDDSEDDREDDASASQRSTPIR 777

Human   781 MTDAGDSAKVTENVVQPMKELYGINLSDGLSEEDFSIYSRFVQLGQSQHKQDKNSQQPCSRCSDG 845
            :|:........:..:...:|.||:||.....:||..||.||..|||:|||.:::...   :.||.
Zfish   778 LTETSHEDPGPQQRLPAARETYGLNLLASPPDEDILIYHRFAHLGQNQHKVERHDDM---KKSDA 839

Human   846 VIKLTPISAFSQDNIYEVQPPRVDRKSTEIFQAHIQASQGIMQPLGKEDSSMYREYIRNRYL 907
            ||.|.|:|.|:.|:||||..|.||.:|..:|:.|:|.::|.::.||:||..||||||||||:
Zfish   840 VISLAPVSVFASDSIYEVCAPEVDVQSRNLFETHVQTARGWVRTLGQEDVLMYREYIRNRYM 901

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
FIG4	NP_055660.1	Syja_N	93..423	CDD:460545	269/330 (82%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	707..788		58/80 (73%)
fig4a	XP_073789868.1	None