DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment TELO2 and lqfR

DIOPT Version :9

Sequence 1:	XP_011521075.1	Gene:	TELO2 / 9894	HGNCID:	29099	Length:	899	Species:	Homo sapiens
Sequence 2:	NP_732736.2	Gene:	lqfR / 42632	FlyBaseID:	FBgn0261279	Length:	1415	Species:	Drosophila melanogaster

Alignment Length:	1009	Identity:	230/1009 - (22%)
Similarity:	374/1009 - (37%)	Gaps:	256/1009 - (25%)

- Green bases have known domain annotations that are detailed below.

Human     2 EPAPSEVRLA-------VREAIHALSSSEDGGHIFCTLESLKRYLGEM-EPPALP---------- 48
            :|....:|||       :|:.:...|:|        .:..:...|||: ...|||
  Fly   512 QPPSEAMRLAFSKAQKQLRDLMQVQSAS--------AVAQVAAILGELHNSNALPGFTTPEQLVG 568

Human    49 --REKEEF---ASAHFSPVLRCLASRLSPAWLE-----------LLPHG-------------RLE 84
              |:..::   |...::.:|..|....|..|.|           .|.|.             ||:
  Fly   569 LDRQTCDWTCLAHGEYAALLNQLTELFSQDWPEPSQDVEVVNIFKLDHSFDYVSVAFESLQTRLD 633

Human    85 EL--WASFFLEGPADQAFLVLMETIEGAAGPSFRLMKMAR----LLARFLREGRLAVLMEAQCRQ 143
            :.  ..|..||.......|:           |..|:.::|    |:.||.|  .:.|:.|.:..:
  Fly   634 KFPSTISSLLENMVKDESLI-----------SIALLHISRQRASLMQRFAR--TIKVMPERKVEE 685

Human   144 ---QTQPGFILLRETLLGKVVALPDHLGNRLQQENLAEFFPQNYFRLLGEEVVR----VLQAVVD 201
               |.:..|.||        ::||..:.|||.:.....|.|.:|.:||..:.::    |||...:
  Fly   686 LDAQVKAFFQLL--------ISLPAQVANRLGRRLPETFAPVSYQKLLLRQWLKSLHFVLQCDDN 742

Human   202 SLQGGLDSSVSFVSQVLGKACVHGRQQEILGVL-----VPRLAALTQGSYLHQRVCWRLVEQVPD 261
            .....|:.....:||.:.........:.:|.||     .||          .::|...:::::..
  Fly   743 REYFDLEPYSWLLSQAINLIYDVSTLESLLRVLKDYAVAPR----------GRKVVHTILKELDP 797

Human   262 RAMEAVLTGLVEAALGPEVLSRLLGNLVVKNKKAQFVMTQKLLFLQSRLTTPMLQSLLGHLAMDS 326
            .|........:.|.|.   |..|:|...::....:..:.|||...::.:....|.:|..:|   :
  Fly   798 AACLKTAQSALSAGLN---LYVLIGAATLETPHWKHCLLQKLPLQRTPVDNKQLITLASYL---N 856

Human   327 QRRPLLLQV-LKELLETWGSSSAIRHTPLPQQRH--VSKAVLI---CLAQLGEPELRDSRDELLA 385
            ...|..||| |.:||..|  |..|....|..|.|  :||.:::   ||......:|...|
  Fly   857 AVAPAQLQVLLNQLLGIW--SKRISLQKLGSQEHLAISKLLVLAAKCLCGNLVMDLNIQR----- 914

Human   386 SMMAGVKCRLDSSLPPVRRLGMIVAEVVSARI----HPEGPPLKFQYEE----------DELSLE 436
            .:..|:...|.|.....|.:||...|::...|    ..|...|:|:|:.          :|.. |
  Fly   915 QLHDGLSNHLQSPDALQRHVGMKTVELIFNFIALPDAKEDDRLRFEYDSFKDTFHWHIFEEFD-E 978

Human   437 LLALASP-------QPAGDGAS--EAGTSLVPATAE--PPAETPAEIVDGGVPQAQLAGS--DSD 488
            |....||       :|..|...  |...|...:|.|  .|.:...||.....|:.|....  |||
  Fly   979 LGQFESPSKTKLDEKPCEDQLKQLELHLSDFMSTTEQKEPHKPNIEIQANPAPENQNVNMQLDSD 1043

Human   489 LD-----SDDEFVPYDMSGDRELKSSKAPAYVRDCVEALTTS-EDIERWEAALRALEGLVYRSPT 547
            .|     .|||..|||||.|......:.|.:|.|.:..|... |:.:.:|.||...|.|: |...
  Fly  1044 DDEPLDEDDDELKPYDMSNDTTTTIDQRPKFVIDLLHLLREKVENYQVFEGALGTAEQLI-RGQL 1107

Human   548 ATR--EVSVELAKVLLHLEEKTCVVGFAGLRQRALVAVTVTDPAPVADYLTSQFYALN--YSLRQ 608
            |..  :::::|.::.|.:|.:.....|...:.:..||:.|..|.|.|:||..||:..|  ||...
  Fly  1108 AKHDTQLALDLLQLFLVMEMQFYYEQFERTQFKCCVAICVAHPGPCAEYLCRQFHTDNSFYSASV 1172

Human   609 RMDILDVLTLAAQELSRPGCLGRTPQPGSPSPN-----TPCLPEAA-----------VSQPGSAV 657
            |:.||.||...|:|||           |..:..     ...:|.||           ...|.:.:
  Fly  1173 RILILQVLAATAKELS-----------GDENMQNEMEIVDVIPPAAKHPRKFEFQQEEESPAARL 1226

Human   658 ASDWRVVVEERIRSKTQR-LSKGGPRQGPAGSPSR-FNSVAGHFFFPLLQRFDRQGASRKIPLWL 720
            |:..| ::.:|:|:||:| .||  |:.|.....:. |:.|||.|||.|
  Fly  1227 AAAQR-IIRDRLRAKTKRYFSK--PKAGDQMEKANPFHPVAGTFFFSL----------------- 1271

Human   721 SFAMRHQASAPMLGLWHGRQCRPHVPDAITCWALLASSCLSRRCTGPTFRAPLVTFDLLGEDQLV 785
               :|.|.:..||.:.:..                                  ::.|:   |..:
  Fly  1272 ---VRGQRTRQMLYVKYEN----------------------------------ISHDI---DTQL 1296

Human   786 LGRLAHTLGALMCLAVNTTVAVAMGKALLEFVWALRFHIDAYVRQGLLSAVSSVLLSLPAARLLE 850
            |..|.:|:..|:..:.|..:..||.:.:.:....:||:.:|.||...|..:...|::.||..|.:
  Fly  1297 LVNLLNTMSVLVMCSQNCPLLPAMTREIFDLCAFVRFNAEARVRAATLQLIGIALVTTPAHVLAQ 1361

Human   851 DLMDELLEARSWLADVAEK-----DPDEDCRTLA 879
            ...:.|.|.:.||.|....     :..|:||.||
  Fly  1362 HFAESLNELQRWLNDFIRSPLVGGETSEECRELA 1395

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
TELO2	XP_011521075.1	Telomere_reg-2	512..620	CDD:287202	34/112 (30%)
lqfR	NP_732736.2	ENTH_epsin	27..150	CDD:239627
		DUF4045	<226..459	CDD:289995
		Telomere_reg-2	1072..1184	CDD:287202	34/112 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	60	1.000	Domainoid score	I10612
eggNOG	1	0.900	-	-		E1_KOG4346
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D177926at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	7	6.780