Protein Alignment TBC1D4 and GAPcenA

DIOPT Version :10

• Sequence 1: NP_055647.2
• Gene: TBC1D4 / 9882
• HGNCID: 19165
• Length: 1298
• Species: Homo sapiens
• Sequence 2: NP_001097549.1
• Gene: GAPcenA / 38945
• FlyBaseID: FBgn0035879
• Length: 1194
• Species: Drosophila melanogaster
• Alignment Length: 1230
• Identity: 278/1230 - (22%)
• Similarity: 469/1230 - (38%)
• Gaps: 336/1230 - (27%)

Human   184 EDAKPSKDNEDAFYNSQKFEVLYCGKVTVTHKKAPSSLIDDCMEKFSLHEQQRLKIQGEQR--GP 246
            :|...:|.:|.:...|.::|:     ||.::..:|       ||:.    :|.:..:|.|.  |.
  Fly     2 DDNLSTKSSESSITTSGEYEI-----VTDSNVASP-------MEQV----KQVVNQEGTQPEVGG 50

Human   247 DPGEDLADLEVVVPGSPGDCLPEEADGTDTHLGLPAGASQPALTSSRVCFPERILEDSGFDEQQE 311
            .|...|:.|.:..|.:.||                   ..|.|..:.    .|.|.|.    |.|
  Fly    51 KPPTSLSALALSSPEAGGD-------------------RSPTLDMAH----NRNLSDM----QHE 88

Human   312 FRSRCSSVTGVQRRVHEGSQKSQPRRRHASAPSHVQPS-------------DSEKNRTMLFQVGR 363
            .......:. ::|.|....:||..|     .|||.|.|             |.|.         |
  Fly    89 MTDALKDLE-LERGVAASGEKSAQR-----LPSHQQKSLTLPLTGSGGGSVDPEM---------R 138

Human   364 FEINLISPDTKSVVLEKNFKDISSCSQGIKHVDHFGFI-----CRE------SPEPGLSQYICYV 417
            |...|.:|.::..:      |.:|.|..:.|...:..|     |.|      .||.|
  Fly   139 FPCTLFTPKSEETL------DDASSSNRVGHSVFYDCIDASPACVEEKQDAMKPEKG-------- 189

Human   418 FQCASESLVDEVMLTLKQA---FSTAAALQSAKTQIKLCEACPMHSLHKLCERIEGLYPPRAKLV 479
                  ...||.:..:.|.   ||....|.:|                       .:..|:::..
  Fly   190 ------DTTDEEVSEIDQGCTIFSGVTYLGAA-----------------------NINAPKSETE 225

Human   480 IQRHLSSLTDNEQADIFERVQKMKPVSDQEENE-LVILHLRQLCEAKQKTHVHIGEGPSTISNST 543
            :.|.:..|....::     |.....||....:| ||:||     :|:..|.:...|..|.|....
  Fly   226 VYRIMGELNSGSKS-----VGLKITVSIPNCSEGLVVLH-----DAESNTIIATYEISSIILYYR 280

Human   544 IPENATSSGRFKLDILKN--------------KAKRSLTSSLENIFSRGANRMRGRLGSVDSFER 594
            .|.:...:|.|....|..              :|...:::..:..|......|...|.|  :.:.
  Fly   281 GPVDTVENGCFAFTWLHGDALFQCHVFRCHIPEAVNQVSACFQKAFQTYPPSMSCSLNS--AVDM 343

Human   595 SNSLASEKDYSPGDSPPGTPPAS------PPSSAWQTFPEEDSDSPQFRRRAH-------TFSHP 646
            :||:.|:...:|.::.......|      ...:::...|.   |...|:.||:       |....
  Fly   344 ANSVTSDVSGNPLNTAGYEFIVSLEIRERVAKNSYAAVPR---DRGCFKLRANTDKEVCITVKQT 405

Human   647 PSSTKRKLNLQ---------------------DGRAQGVRSPLLRQSSSEQCSNLSSVRRMYKES 690
            ||:..:.|:::                     |..:.|...|.....::|..||          :
  Fly   406 PSNVLQPLHIERCFGVLVAPGKLVVQKDMHLIDMHSMGYIQPGGTGVATESDSN----------A 460

Human   691 NSSSSLPSLHTSFSAPSFTAPSFLKSFYQNSGRLSPQYENEIRQDTASESSDGEGRKRTSSTCSN 755
            ..|||.|          :|..:..|:                 |:.|.|..:.|..|      :|
  Fly   461 QQSSSWP----------YTIRAEWKA-----------------QEKAFEQLNLESSK------TN 492

Human   756 ESLSVGGTSVTPRRISWRQRIFLRVASPMN-KSPSAMQQQDGLDRNELLPLSPLSPTMEEEPLVV 819
            .:::|   .:..|||  ::.:...:.:|:. :|.|.|:..|..              |.:.|:.:
  Fly   493 LTVAV---DIVMRRI--QEPVRFVIETPVTIQSASEMRIMDHF--------------MSKRPMTL 538

Human   820 --------------FLSGEDDPEKIEERKKSKELRSLWRKAIHQQILLLRMEKENQKLEASRDEL 870
                          .::..|..|:|.|:...::..||.:..::....::|    :..:.:..|:.
  Fly   539 RFYLHLKRTEESNWKVNSIDPSEEITEQPGHQQSSSLLKMGMNNLSRIVR----SSSIASIEDDC 599

Human   871 QSRKVKLDYEEVG-------------ACQKEVLITWDKKLLNCRAKIRCDMEDIHTLLKEGVPKS 922
            .|     ||...|             .|.::.|..||..|....::.|  .:::..|::.|||::
  Fly   600 PS-----DYSSDGDEPLLSGTGEVSKDCSQDTLDEWDPILREWDSEKR--PKNLAPLVRLGVPEA 657

Human   923 RRGEIWQFLALQYRLRHRLPNKQQPPDISYKELLKQLTAQQHAILVDLGRTFPTHPYFSVQLGPG 987
            .|.:|||.||       .:..:.:..| .||.|:.:.|..:..|..|:.||||.|..|....|.|
  Fly   658 LREKIWQKLA-------NVEGRMEMND-KYKILITKETKCETVIQRDIHRTFPAHKCFKEIGGSG 714

Human   988 QLSLFNLLKAYSLLDKEVGYCQGISFVAGVLLLHMSEEQAFEMLKFLMYDLGFRKQYRPDMMSLQ 1052
            |.:||.:.|||::.|.|||||||:||:|..|||||.||.||.:|..||||.|.|..|:.....|.
  Fly   715 QDALFKVSKAYAVHDSEVGYCQGLSFIAASLLLHMPEEDAFCVLVALMYDYGLRDLYKAGFEVLY 779

Human  1053 IQMYQLSRLLHDYHRDLYNHLEENEISPSLYAAPWFLTLFASQFSLGFVARVFDIIFLQGTEVIF 1117
            :::|||.||:.|....|:.|.....|...:||:.|||||:.::|.|.||..|.|:..|.|..|:|
  Fly   780 LRLYQLERLIKDQLPKLHEHFTACGIETHMYASQWFLTLYTARFPLCFVFHVLDVFLLDGLPVLF 844

Human  1118 KVALSLLSSQETLIMECESFENIVEFLKNTLPD--MNTSEMEKIITQVFEMDISKQLHAYEVEYH 1180
            :||::|||..|:.:.:.: ||.|:::.:.|||.  .::|:..|::.|..|..| |:|..||.|:.
  Fly   845 QVAVTLLSICESDLRQLD-FEGILKYFRVTLPKKCRSSSQARKVMKQACERKI-KKLKQYEEEFL 907

Human  1181 V-------LQDELQ--ESSYSCEDSETLEKLERANSQLKRQNMDLLEKLQVAHTKIQALESNLEN 1236
            :       |:.|.|  |:.:..|..:...:::..|.||.......:|| :..||.|
  Fly   908 LKKQHKERLEKEAQIYENRFGEERRKMQAEIDALNKQLTSAKERAVEK-EKKHTGI--------- 962

Human  1237 LLTRETKMKSLIRTLEQEKMAYQKTVEQLRKLLPADALVNCDLLLRDLNC-NPNNKAKIG 1295
                ..:.|.:|:..||:.....:|:.::..::.     ||....:.::. |.|.|:..|
  Fly   963 ----IQEYKQIIQRQEQDMNTLSETLGKVMHMVS-----NCQDCQQQIDAGNDNAKSDDG 1013

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TBC1D4	NP_055647.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..31
		PTB	31..190	CDD:214675	1/5 (20%)
		PTB_TBC1D1_like	193..437	CDD:269967	54/272 (20%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	241..287		9/47 (19%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	317..353		11/48 (23%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	586..685		22/132 (17%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	725..765		7/39 (18%)
		DUF3350	801..864	CDD:463365	9/76 (12%)
		TBC	918..1132	CDD:214540	91/213 (43%)
		COG4372	1161..>1267	CDD:443500	26/114 (23%)
GAPcenA	NP_001097549.1	PTB_Rab6GAP	204..332	CDD:269922	26/160 (16%)
		DUF3694	377..523	CDD:463599	33/196 (17%)
		TBC	650..858	CDD:214540	91/215 (42%)
		SMC_prok_B	<876..>1087	CDD:274008	34/158 (22%)
		TPH	<883..>977	CDD:464007	26/108 (24%)