Protein Alignment TBC1D4 and Tbc1d15-17

DIOPT Version :10

• Sequence 1: NP_055647.2
• Gene: TBC1D4 / 9882
• HGNCID: 19165
• Length: 1298
• Species: Homo sapiens
• Sequence 2: NP_608503.1
• Gene: Tbc1d15-17 / 33184
• FlyBaseID: FBgn0031233
• Length: 715
• Species: Drosophila melanogaster
• Alignment Length: 730
• Identity: 154/730 - (21%)
• Similarity: 268/730 - (36%)
• Gaps: 190/730 - (26%)

Human   544 IPENATSSGRFKLD-ILKNKAKRSLTSSLENIFSRGANRMRGRLGSVDSFERSNSLASEK----- 602
            :|:..|.:..|..| :|..||      |.|:|.....:      ||:...|.|.|:|...
  Fly    33 LPQQGTGNILFTHDGVLLKKA------SAEHIADLNTS------GSLSLVEYSRSIAEMPRRRLL 85

Human   603 -DYSPGDSPPGTPPASPPSSAWQTFPEEDSDS-------PQFRRRAHTFSHPPSSTKRKLNLQDG 659
             ::.|.||               ....:||..       .:...|..|.|...:...|.:....|
  Fly    86 LEWQPNDS---------------IMIADDSQDQGDWALVDRISGRTRTTSECRAFNTRPIEPSGG 135

Human   660 ---RAQGVRSPLLRQSSSEQCSNLSSVRRMYKESNSSSSLPSLHTSFSAPSFTAPSFLKSFYQNS 721
               |::.:|:.|...||.|......::|.|.|.:|      .:|:.|......|..|::|.
  Fly   136 ATTRSRVMRAQLEDLSSVEVRHRGQTIRFMRKGAN------GVHSEFFFQHGNADLFVRSM---- 190

Human   722 GRLSPQYENEIRQDTASESSDGEGRKRTSSTCSNE-------SLSVG--GTSVTPRRISWRQRIF 777
             |.....||       :|:|...|......|..|:       .|.:|  ..|..||. ||...
  Fly   191 -RDQHLIEN-------AETSRSGGEVYAILTTENQKLKKTFAELDIGQIKASQLPRE-SWLPN-- 244

Human   778 LRVASPMNKSPSAMQ---QQDGLDRNELLPLSPLSPTMEEEPLVVFLSGEDDPE----------K 829
             ::|..:...|..:|   |:....|..:| :|....|..:...::.|||..:..          .
  Fly   245 -KLAGILGNIPDYVQPPFQRSPKSRPGVL-ISGDRQTSPDNYQIIGLSGSTNSACSSNGQSRGGS 307

Human   830 IEERKKSKELRSLWRKAIHQQIL-----LLRMEKENQKLEASRDELQSRKVKLDYEEVGACQKEV 889
            .|:.....||.:|  .|..::|:     ..|:|:.:...|....|.|
  Fly   308 AEKSPADSELETL--NAQDEKIVNNLPDRQRVERGHPLTETQWLEFQ------------------ 352

Human   890 LITWDKKLLNCRAKIRCDMEDIHTLLKEGVPKSRRGEIWQFLALQYRL---RH--RLPNKQQPPD 949
              |.|.::.: .|:|:      ..:.:.||.:|.|.|:|:|| |.|.|   .|  |:..::| ..
  Fly   353 --TPDGRISD-SARIK------ELIFRGGVVQSLRPEVWKFL-LNYYLWSDTHVERIERRKQ-KS 406

Human   950 ISYKELLKQ---LTAQQHA-----------ILVDLGRTFPTHPYFSVQLGPGQLSLFNLLKAYSL 1000
            |.|..:..|   :|..|.|           |..|:.||..:..:|:.:..|....|..:|..|.:
  Fly   407 IEYYNMKAQWLAMTTTQEANFCGYRERKCQIEKDVKRTDRSLQFFAGEDNPNLTLLQGILMTYVM 471

Human  1001 LDKEVGYCQGIS-FVAGVLLLHMSEEQ------AFEMLKFLMYDLGFRKQYRPDMMSLQIQMYQL 1058
            .:.::||.||:| .:|.:|.:.::|..      .|..|.|..:|:        |...::.|..|:
  Fly   472 YNFDLGYVQGMSDLLAPILEIQVNEVDTFWCFVGFMELVFTNFDI--------DQAGMKTQFAQI 528

Human  1059 SRLLHDYHRDLYNHLEENEISPSLYAAPWFLTLFASQFSLGFVARVFDIIFLQ----GTEVIFKV 1119
            .||:...:..|:|::..::.....:...|.|..:..:.:...|.::::.::.:    ...::|.|
  Fly   529 RRLIEFANAPLFNYMRSHDSDNMYFCFRWLLVWYKRELNSEDVLKLWECLWTRLPCPNFHLLFSV 593

Human  1120 ALSLLSSQETLIMECESFENIVEFLKNTLPDMNTSEMEKIITQVFEMDISKQLHAYEVEYHVLQD 1184
            |   :..|||.::....:| ..|.||      :.:|:..      .:|:.|.|...|..|..|
  Fly   594 A---ILDQETRVIIDSQYE-FTEILK------HVNELSG------NIDVQKTLQVAEGIYLQL-- 640

Human  1185 ELQESSYSCEDSETL 1199
                     :.||||
  Fly   641 ---------KGSETL 646

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TBC1D4	NP_055647.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..31
		PTB	31..190	CDD:214675
		PTB_TBC1D1_like	193..437	CDD:269967
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	241..287
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	317..353
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	586..685		22/114 (19%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	725..765		9/48 (19%)
		DUF3350	801..864	CDD:463365	14/77 (18%)
		TBC	918..1132	CDD:214540	57/243 (23%)
		COG4372	1161..>1267	CDD:443500	10/39 (26%)
Tbc1d15-17	NP_608503.1	TBC	369..598	CDD:214540	54/241 (22%)