DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment DDX46 and CG6227

DIOPT Version :9

Sequence 1:NP_001287789.1 Gene:DDX46 / 9879 HGNCID:18681 Length:1032 Species:Homo sapiens
Sequence 2:NP_573020.2 Gene:CG6227 / 32464 FlyBaseID:FBgn0030631 Length:1224 Species:Drosophila melanogaster


Alignment Length:1233 Identity:613/1233 - (49%)
Similarity:766/1233 - (62%) Gaps:244/1233 - (19%)


- Green bases have known domain annotations that are detailed below.


Human     3 RESRH-YRKRSASRGRS------GSRSRSRSPSDKRSKRGDDRRS-RSRDRDRRRERSRSRDKRR 59
            |::|| .|.|....|:|      |:...||:..:.| |||.|..| |.:..|:||:.|||:|..:
  Fly    33 RDNRHDSRSRDYDMGKSRNGGGGGAGGGSRNMREDR-KRGKDMISDRGKRDDKRRKCSRSKDYEK 96

Human    60 SRSRDRKRLRRSRSRERDRSRERRRSRSRDRRRSRSRSRGRRSRSSSPGNKSKKTENRSRSKEKT 124
            ..|...:||.:.|.|:|||.|:|.:.|.|::.:.|.:.:.|         :..|...|.|.:||.
  Fly    97 DNSPHYRRLDKDRDRDRDRDRQREKEREREKEKEREKEKER---------ERDKDRERDRQREKE 152

Human   125 DGGE---------------SSKEKKKDKDDKEDEKEKDAGNFDQNKLEEEMRKRKERVEKWREEQ 174
            ....               |..|::.::.|||::         |.:||:||.||:||:|:||.|:
  Fly   153 SDSRRAAAAAPLIIPLLSTSCSEEEVEEIDKEEQ---------QRRLEQEMIKRRERIERWRAER 208

Human   175 RK--KAMENIGELKKEIEEMKQGKKWSLEDDDDDEDD---------------------------- 209
            ::  ||......|      :...|||||||:.:::|.                            
  Fly   209 KRDTKAAVVAPSL------VNSAKKWSLEDESEEDDSNPAPPLDSGKKDAEPDSPPSKFHSIRKR 267

Human   210 ------------------------------------------PAEAEKE---------------- 216
                                                      |.:.:||                
  Fly   268 FDDDVVESKFSPVKRPTFSKSFGKLGIGLATKAEADIKKEPPPVDTKKEIKKKPEPVAAKMEIVE 332

Human   217 -------------------GNEMEGE-------------ELDPLDAYMEEVKEEVKKFNMRSVKG 249
                               |.:.|.|             |:|||||||:||..|     ||.|..
  Fly   333 EPTVAAGEKTKKEPEQPHVGAKSEPEVEDKPQPEAEPEDEIDPLDAYMQEVNNE-----MRRVNN 392

Human   250 GGGNEKKSGPTVTKVVTVVTTKKAVVDSDKKKGELMENDQDAMEYSSEEEEVDLQTALTGYQTKQ 314
            ......||...|  ::|.|..||.   :..||||::|.:.|::|||||:|..|::........|.
  Fly   393 FVNPPAKSQGVV--ILTGVAKKKT---TTLKKGEVIEQNMDSLEYSSEDELEDIRDTAVNLAMKH 452

Human   315 RKLLEPVDHGKIEYEPFRKNFYVEVPELAKMSQEEVNVFRLEMEGITVKGKGCPKPIKSWVQCGI 379
            ||.|..:||..:.|.|||||||||||||.:|:..:|..:|.::|||.|||||||||||:|.|||:
  Fly   453 RKELAKIDHSSVTYAPFRKNFYVEVPELTRMTAADVEKYRSDLEGIQVKGKGCPKPIKTWAQCGV 517

Human   380 SMKILNSLKKHGYEKPTPIQTQAIPAIMSGRDLIGIAKTGSGKTIAFLLPMFRHIMDQRSLEEGE 444
            |.|.:..|::.|:|||||||.|||||||||||||||||||||||:||:|||||||:||.|:|:|:
  Fly   518 SKKEMEVLRRLGFEKPTPIQCQAIPAIMSGRDLIGIAKTGSGKTLAFILPMFRHILDQPSMEDGD 582

Human   445 GPIAVIMTPTRELALQITKECKKFSKTLGLRVVCVYGGTGISEQIAELKRGAEIIVCTPGRMIDM 509
            |.||:||.|||||.:||.|:.:||||:||||.|||||||||||||||||||||||||||||||||
  Fly   583 GAIAIIMAPTRELCMQIGKDIRKFSKSLGLRPVCVYGGTGISEQIAELKRGAEIIVCTPGRMIDM 647

Human   510 LAANSGRVTNLRRVTYVVLDEADRMFDMGFEPQVMRIVDNVRPDRQTVMFSATFPRAMEALARRI 574
            |||||||||||||||||||||||||||||||||||||:||||||||||||||||||.||||||||
  Fly   648 LAANSGRVTNLRRVTYVVLDEADRMFDMGFEPQVMRIIDNVRPDRQTVMFSATFPRQMEALARRI 712

Human   575 LSKPIEVQVGGRSVVCSDVEQQVIVIEEEKKFLKLLELLGHYQESGSVIIFVDKQEHADGLLKDL 639
            |.|||||.||||||||.:|||.|:::.::.||.|||||||.|||:||:|:||||||:||.||:||
  Fly   713 LKKPIEVIVGGRSVVCKEVEQHVVILNDDAKFFKLLELLGIYQEAGSIIVFVDKQENADILLRDL 777

Human   640 MRASYPCMSLHGGIDQYDRDSIINDFKNGTCKLLVATSVAARGLDVKHLILVVNYSCPNHYEDYV 704
            |:||||||||||||||:||||.|.|||:|..:||:||||||||||||.|||||||..||||||||
  Fly   778 MKASYPCMSLHGGIDQFDRDSTIIDFKSGKVRLLIATSVAARGLDVKDLILVVNYDVPNHYEDYV 842

Human   705 HRAGRTGRAGNKGYAYTFITEDQARYAGDIIKALELSGTAVPPDLEKLWSDFKDQQKAEGKIIKK 769
            ||.|||||||.||.||||||.:|:|||||||:|::||||.:|.:|:.||:::|..|:||||.:..
  Fly   843 HRCGRTGRAGKKGSAYTFITPEQSRYAGDIIRAMDLSGTLIPAELQALWTEYKALQEAEGKTVHT 907

Human   770 SSGFSGKGFKFDETEQALANERKKLQKAALGLQDSDD-EDAAVDIDEQIESMFNSKKRVKDMAAP 833
            ..|||||||||||.|...|.|.||||||||||.|||| ||...|||:|||.:|.:|:.|||.:|.
  Fly   908 GGGFSGKGFKFDEQEFNAAKESKKLQKAALGLADSDDEEDIEQDIDQQIEQIFAAKRTVKDTSAA 972

Human   834 GT-------------------------------------------SSVPAPTAG----------N 845
            .|                                           :|.||...|          :
  Fly   973 ATAAAAAAAAAAAAAAAVSGANPALASAAAQAAAAAAAANIAIAAASAPAAAGGAPSVAMGGALS 1037

Human   846 AEKLEIAKRLALRINAQKNLGIESQVDVMQQATNAILRGGTI---LAPTVSAKTIAEQLAEKINA 907
            ::|||:|||||.:||:.|||..:..|..::    .:::|..:   .|..::|:|:|||:|.|:|.
  Fly  1038 SDKLELAKRLASKINSSKNLDTKGSVVTVE----PMIKGPHVTGAAATLLTARTVAEQMAAKLNN 1098

Human   908 KLNYVPLEKQEEERQD---GGQNESFKRYEEELEINDFPQTARWKVTSKEALQRISEYSEAAITI 969
            ||||.|  |::||...   ||....|.:||||||||||||.|||||||||||.:|||||||.:|:
  Fly  1099 KLNYQP--KEDEEGLGPLVGGTTNPFTKYEEELEINDFPQQARWKVTSKEALAQISEYSEAGLTV 1161

Human   970 RGTYFPPGKEPKEGERKIYLAIESANELAVQKAKAEITRLIKEELIRLQNSYQPTNKGRYKVL 1032
            ||||.|.||.|.:||||:||||||.:||||||||.||||||||||::|.:::...|||||||:
  Fly  1162 RGTYVPQGKNPPDGERKLYLAIESCSELAVQKAKREITRLIKEELLKLSSAHHVFNKGRYKVV 1224

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
DDX46NP_001287789.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..228 80/367 (22%)
SrmB 344..826 CDD:223587 362/482 (75%)
DEADc_DDX46 361..582 CDD:350711 185/220 (84%)
Q motif 372..400 15/27 (56%)
DEAD box 529..532 2/2 (100%)
CG6227NP_573020.2 SrmB 482..967 CDD:223587 362/484 (75%)
DEADc 516..719 CDD:238167 170/202 (84%)
HELICc 733..860 CDD:238034 95/126 (75%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 326 1.000 Domainoid score I1189
eggNOG 1 0.900 - - E2759_KOG0334
Hieranoid 1 1.000 - -
Homologene 1 1.000 - - H5430
Inparanoid 1 1.050 1046 1.000 Inparanoid score I262
Isobase 1 0.950 - 0 Normalized mean entropy S1040
OMA 1 1.010 - - QHG54542
OrthoDB 1 1.010 - - D146665at33208
OrthoFinder 1 1.000 - - FOG0004627
OrthoInspector 1 1.000 - - oto90155
orthoMCL 1 0.900 - - OOG6_102375
Panther 1 1.100 - - LDO PTHR24031
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R985
SonicParanoid 1 1.000 - - X2240
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
User_Submission 00.000 Not matched by this tool.
1615.820

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