Protein Alignment TOX4 and CG12104

DIOPT Version :10

• Sequence 1: NP_055643.1
• Gene: TOX4 / 9878
• HGNCID: 20161
• Length: 621
• Species: Homo sapiens
• Sequence 2: NP_647629.1
• Gene: CG12104 / 38187
• FlyBaseID: FBgn0035238
• Length: 250
• Species: Drosophila melanogaster
• Alignment Length: 590
• Identity: 114/590 - (19%)
• Similarity: 157/590 - (26%)
• Gaps: 345/590 - (58%)

Human    27 FHTPSLGDEEFEIPPISLDSDPSLAVSDVVGHFDDLADPSSSQDGSFSAQYGVQTLDMPVGMTHG 91
            |||||.|||.||:             :|.         |:.||..|.:::
  Fly     4 FHTPSFGDEVFEL-------------TDT---------PAESQSPSQASR--------------- 31

Human    92 LMEQGGGLLSGGLTMDLDHSIGTQYSANPPVTIDVPMTDMTSGLMGHSQLTTIDQSELSSQLGLS 156
                        ..:.||.|:                              ..|..|.:.....|
  Fly    32 ------------RMLSLDQSM------------------------------LNDDDEENCDTYAS 54

Human   157 LGGGTILPPAQSPEDRLSTTPSPTSSLHEDGVEDFRRQLPSQKTVVVEAGKKQKAPKKRKKKDPN 221
            .||..:|   ..||.:                         |...:.:|
  Fly    55 GGGQNLL---VQPEQQ-------------------------QNQAMAQA---------------- 75

Human   222 EPQKPVSAYALFFRDTQAAIKGQNPNATFGEVSKIVASMWDSLGEEQKQVYKRKTEAAKKEYLKA 286
             |.||::.:|||||||..|||.|||..:..::..||.:||:||.|.||.||..:.|..|:||::.
  Fly    76 -PPKPLAPFALFFRDTVTAIKQQNPTCSLEQMQVIVQTMWESLDETQKNVYALRHEQEKREYVRL 139

Human   287 LAAYKDN-QECQATVETVELDPAPPS-QTPSPPPMATVDPASPAPASIEPPALSPSIVVNSTLSS 349
            :..|:.. .|.:.|.|.    .|||: .|..|||:.|
  Fly   140 MRGYRHQLSESEGTSEA----EAPPAVATNQPPPLVT---------------------------- 172

Human   350 YVANQASSGAGGQPNITKLIITKQMLPSSITMSQGGMVTVIPATVVTSRGLQLGQTSTATIQPSQ 414
                            |||
  Fly   173 ----------------TKL---------------------------------------------- 175

Human   415 QAQIVTRSVLQAAAAAAAAASMQLPPPRLQPPPLQQMPQPPTQQQVTILQQPPPLQAMQQPPPQK 479
                                                       :.|..|||
  Fly   176 -------------------------------------------ESVEDLQQ-------------- 183

Human   480 VRINLQQQPPPLQIKSVPLPTLKMQTTLVPPTVESSPERPMNNSPEAHTVEAPSPETICEMITDV 544
             .::.||:|||.||:.:                           .||..|:
  Fly   184 -SVDAQQEPPPDQIQLL---------------------------TEAARVQ-------------- 206

Human   545 VPEVESPSQMDVELVSGSPVALSPQPRCVRSGCENPPIVSKDWDNEYCSNECVVKHCRDVFLAWV 609
                                      :|.|..|..|.|::.||::|||||||||.|||:||..||
  Fly   207 --------------------------KCTREQCNKPAIINPDWEDEYCSNECVVIHCRNVFNHWV 245

Human   610 ASRNS 614
            .|.||
  Fly   246 ISMNS 250

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TOX4	NP_055643.1	NHP6B	140..>306	CDD:227935	45/166 (27%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	153..227		10/73 (14%)
		Nuclear localization signal. /evidence=ECO:0000255	213..218		0/4 (0%)
		HMG-box_TOX-like	224..293	CDD:438811	31/68 (46%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	305..333		8/28 (29%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	510..529		2/18 (11%)
CG12104	NP_647629.1	HMG-box_SF	78..144	CDD:469606	30/65 (46%)