Protein Alignment Kcnb2 and Shawl

DIOPT Version :9

• Sequence 1: NP_001091998.1
• Gene: Kcnb2 / 98741
• MGIID: 99632
• Length: 907
• Species: Mus musculus
• Sequence 2: NP_001097131.2
• Gene: Shawl / 5740840
• FlyBaseID: FBgn0085395
• Length: 937
• Species: Drosophila melanogaster
• Alignment Length: 1050
• Identity: 259/1050 - (24%)
• Similarity: 388/1050 - (36%)
• Gaps: 373/1050 - (35%)

Mouse    36 RVKINVGGLNHEVLWRTLDRLPRTRLGKLRDCNTHESLLEVCDDYNLNENEYFFDRHPGAFTSIL 100
            |:.:||.|:.:|....||.::|.|||.:         |.|...:|:...||||||||||.||.||
  Fly     6 RIILNVSGIRYETYKATLKKIPATRLSR---------LTEALANYDPVLNEYFFDRHPGVFTQIL 61

Mouse   101 NFYRTGKLHMMEEMCALSFGQELDYWGIDEIYLESCCQARYHQKKEQMN-----EELRREAETMR 160
            |:|||||||...::|...|.:||::||:|...:|.||.:.|...::..|     ::|..|.|...
  Fly    62 NYYRTGKLHYPTDVCGPLFEEELEFWGLDSNQVEPCCWSTYSIHRDTQNTLAILDKLDIENEKPT 126

Mouse   161 ERE-------GEEFDN---TCCPEKRKKLWDLLEKPNSSVAAKILAIVSILFIVLSTIALSLNTL 215
            |.:       .|...|   .|....:.|:|.:.::|:||..|||:|.:|:.||.:|.|:..|.|.
  Fly   127 EEQIARLFGFEEALSNGELNCWQRIKPKIWAMFDEPSSSTGAKIVAGMSVFFIFVSVISFCLKTH 191

Mouse   216 P---------------------------------------------------------------- 216
            |
  Fly   192 PGFRVDLPSGAHDAHGPGAGGPPHGHDPMGEPPQTHQYHQHSITPPSGSIGPTFRVTNYTSYSSG 256

Mouse   217 --------------------ELQEN--------------------------DEFGQPSDNRKLAH 235
                                .|:.|                          :.:|||  :....:
  Fly   257 NFTASGQATPIATIKGGQRQRLKRNINGSILNEFIEEKILGHNGRRKHGWIETYGQP--HEAFFY 319

Mouse   236 VEAVCIAWFTMEYLLRFLSSPNKWKFFKGPLNVIDLLAILPYYVTIFLTESNKSVLQFQNVRRVV 300
            ||.||..||.:|.::|.:.|||.|:|.|.|:|:||..|.|.:|..:        :.:......::
  Fly   320 VELVCNVWFFIEVIIRLIVSPNLWQFIKSPVNIIDFTATLSFYTDV--------MQRMGEYTGLL 376

Mouse   301 QIFRIMRILRILKLARHSTGLQSLGFTLRRSYNELGLLILFLAMGIMIFSSLVFFAEK--DEDAT 363
            :.|.|:||:|:.||.|||.||:.|..|.:.|..||.||:.||.:||:.|:||.::|||  |....
  Fly   377 EAFSIVRIMRLFKLTRHSPGLRILIHTFKASAKELTLLVFFLVLGIVFFASLAYYAEKLQDNPDN 441

Mouse   364 KFTSIPASFWWATITMTTVGYGDIYPKTLLGKIVGGLCCIAGVLVIALPIPIIVNNFSEFYKE-Q 427
            :|.|||...|||.:|||||||||:.|||..|..||.||.:||||.||||:|:||:|||.||.. |
  Fly   442 QFKSIPLGLWWAIVTMTTVGYGDVAPKTYPGMFVGALCALAGVLTIALPVPVIVSNFSMFYSHTQ 506

Mouse   428 KRQEKAIKRREAL----ERAKRN------------------------GSIVSMN----------- 453
            .|.:...|||..|    .|.||.                        |.:|.:.
  Fly   507 ARSKLPKKRRRVLPVEQPRRKREPTAPHRGRTNAIKQTPPTGPGLVAGGVVPVGAGGPGLGGHAV 571

Mouse   454 ---------LKDAFARSMELIDVAVEKAGESANTKDSVDDNHLSPSRWKWARKALSETSSNKSYE 509
                     .||||..:         |.| :.|. :.|:...|.|::......|::
  Fly   572 GHSAAGAPMFKDAFGGA---------KIG-TVNV-NGVNVIGLHPAQRTTTTMAMA--------- 616

Mouse   510 NKYQEVSQNDSHEHLNNTSSSSPQHLSAQKLEMLYNEITKTQPHSHPNPDCQEQPERPCVYEEEI 574
                             .:.:.|..:||...::...:.|.|..|||.:.........|.
  Fly   617 -----------------MNEADPTPMSALTYQVPMLQPTPTPAHSHGHAHGHAHGLGPA------ 658

Mouse   575 EMEEVICPQEQLAVAQTEVIVDMKSTSSIDSFTSCATDFTETERSPLPP----------PSASHL 629
                        :.|.|       |::|:....:.|...|....:|..|          |:...|
  Fly   659 ------------SAAMT-------SSASLTGSAASAAVATAAAAAPAGPSFISSDYLSVPAVQSL 704

Mouse   630 QMKFPTDLPGTDEHQRARAPPFLTLSRDK--GPAAREAAVDYAPIDITVN---------LDAGAS 683
            |.:..|  .|.|         |:...:.|  ||..|:   |..|:.:|.:         :.:|.:
  Fly   705 QPRAAT--TGHD---------FMLPLQPKLLGPLERK---DQHPLQLTAHNLASDTHQLMYSGHA 755

Mouse   684 HGPLQ----------PDSASDSPKSSLKGSNPLKSRSLKVNFQENRASAPQTPPSTARPLPVTTA 738
            |...:          |.:.|.|......|...:..|:..::|:....::.|. .:..:|:|.:.|
  Fly   756 HSQHKVGGGAAVLNVPPTLSMSHTQMPPGIASMGQRTPNLSFRPAHGASSQV-ATVQQPIPHSHA 819

Mouse   739 DFPLTTPQHMSTILLEEALPQGQPPLLEADDSAHCQ--------GPSKGFSPRF--PKQKLFPFS 793
                   .|.||                     :|.        |.|.|....|  ||..|....
  Fly   820 -------CHAST---------------------NCNIKISVASAGLSVGCPDEFRTPKVTLLDDL 856

Mouse   794 SRERRSFTEIDTGEDEDFLDLQRSRPDKQADPSPNCLADKPGDARDSLREEGCVGSSSPQNTDHN 858
            |.:..|.|: |.|:                    .||.|      ||...||...::.|...::.
  Fly   857 SDDVNSSTD-DCGD--------------------CCLVD------DSDTYEGTTINNGPSGQENG 894

Mouse   859 CRQDIYQAVG 868
            .     :|:|
  Fly   895 T-----EAIG 899

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Kcnb2	NP_001091998.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..22
		BTB	37..143	CDD:197585	46/105 (44%)
		BTB_2	37..136	CDD:280393	43/98 (44%)
		Ion_trans	230..428	CDD:278921	91/200 (46%)
		Ion_trans_2	341..422	CDD:285168	48/82 (59%)
		Selectivity filter. /evidence=ECO:0000250|UniProtKB:P63142	381..386		4/4 (100%)
		Kv2channel	471..755	CDD:281514	53/314 (17%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	503..534		1/30 (3%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	680..742		12/71 (17%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	761..859		21/107 (20%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	887..907
Shawl	NP_001097131.2	BTB	7..99	CDD:197585	44/100 (44%)
		BTB_2	7..97	CDD:280393	43/98 (44%)
		Ion_trans	307..506	CDD:278921	94/208 (45%)
		Ion_trans_2	<449..499	CDD:285168	32/49 (65%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X19
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.910