DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment TLK1 and TPK1

DIOPT Version :9

Sequence 1:	NP_036422.3	Gene:	TLK1 / 9874	HGNCID:	11841	Length:	766	Species:	Homo sapiens
Sequence 2:	NP_012371.2	Gene:	TPK1 / 853275	SGDID:	S000003700	Length:	397	Species:	Saccharomyces cerevisiae

Alignment Length:	317	Identity:	86/317 - (27%)
Similarity:	139/317 - (43%)	Gaps:	54/317 - (17%)

- Green bases have known domain annotations that are detailed below.

Human   410 LKKEEAEIQAELERLERVRNLHIRELKRINNEDNSQFKDHPTLN------ERYLLLHLLGRGGFS 468
            ::||..|.|      |:.:..|:   ...|.|...||.....:.      :.:.:|..||.|.|.
Yeast    44 VEKEGGETQ------EKPKQPHV---TYYNEEQYKQFIAQARVTSGKYSLQDFQILRTLGTGSFG 99

Human   469 EVYKAFDLYEQRYAAVKIHQLNKSWRDEKKE-----NYHKHACREYRIHKELDHPRIVKLYDYFS 528
            .|:.....:..||.|:|:         .|||     ...:|...|..:...:.||.|::::..|.
Yeast   100 RVHLIRSRHNGRYYAMKV---------LKKEIVVRLKQVEHTNDERLMLSIVTHPFIIRMWGTFQ 155

Human   529 LDTDTFCTVLEYCEGNDLDFYLKQHKLMSEKEARSIVMQIVNALRYLNEIKPPIIHYDLKPGNIL 593
             |......:::|.||.:|...|::.:......|:....::..||.||:  ...||:.||||.|||
Yeast   156 -DAQQIFMIMDYIEGGELFSLLRKSQRFPNPVAKFYAAEVCLALEYLH--SKDIIYRDLKPENIL 217

Human   594 LVDGTACGEIKITDFGLSKIMDDDSYGVDGMDLTSQGAGTYWYLPPECFVVGKEPPKISNKVDVW 658
            |...   |.|||||||.:|.:.|.:|.:         .||..|:.||  ||..:|  .:..:|.|
Yeast   218 LDKN---GHIKITDFGFAKYVPDVTYTL---------CGTPDYIAPE--VVSTKP--YNKSIDWW 266

Human   659 SVGVIFFQCLYGRKPFGHNQSQQDILQENTILKATEVQFPVKPVVSSEAKAFIRRCL 715
            |.|::.::.|.|..||..:.:.:..   ..||.| |::||  |..:.:.|..:.|.:
Yeast   267 SFGILIYEMLAGYTPFYDSNTMKTY---EKILNA-ELRFP--PFFNEDVKDLLSRLI 317

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
TLK1	NP_036422.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..197
		Smc	209..>454	CDD:224117	10/49 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	346..383
		STKc_TLK1	449..747	CDD:270942	76/278 (27%)
TPK1	NP_012371.2	STKc_PKA_like	85..375	CDD:270732	76/267 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910