Protein Alignment TLK1 and MPS1

DIOPT Version :9

• Sequence 1: NP_036422.3
• Gene: TLK1 / 9874
• HGNCID: 11841
• Length: 766
• Species: Homo sapiens
• Sequence 2: NP_010256.2
• Gene: MPS1 / 851533
• SGDID: S000002186
• Length: 764
• Species: Saccharomyces cerevisiae
• Alignment Length: 797
• Identity: 169/797 - (21%)
• Similarity: 301/797 - (37%)
• Gaps: 224/797 - (28%)

Human    88 STNNESSNHSFGSLGSLS-------DKESETPEKKQSES----SRGRKRKAENQNESSQGKSIGG 141
            |||   |.|.:..|.|.:       |:|..||.|..:..    |...|..|.....|.....|..
Yeast     2 STN---SFHDYVDLKSRTNTRQFSDDEEFTTPPKLSNFGSALLSHTEKTSASEILSSHNNDKIAN 63

Human   142 RGHKISDYFEYQGGNGSSPVRGIPPAIRSPQNSH----SHSTPSSSVRPNSPSPTALAFG----- 197
            |..::.     :..:.|.|    ||::.:..:.|    ||||               .||
Yeast    64 RLEEMD-----RSSSRSHP----PPSMGNLTSGHTSTSSHST---------------LFGRYLRN 104

Human   198 DHPIVQPKQLSFKIIQTDLTMLKLAALESNKIQDLEKKEGRIDDLLRANCDLRRQIDEQQKLLEK 262
            :|             ||.:|.:..:.:|.|....|:|...||.:|        || :.::.:..|
Yeast   105 NH-------------QTSMTTMNTSDIEINVGNSLDKSFERIRNL--------RQ-NMKEDITAK 147

Human   263 YKERLNKCISMSKKLL------------------IEKSTQEKLSSREKSMQDRLRLGHFTTVRHG 309
            |.||.:|...:|.:..                  :..|..:.:::|| :::..|...|.|..:..
Yeast   148 YAERRSKRFLISNRTTKLGPAKRAMTLTNIFDEDVPNSPNQPINARE-TVELPLEDSHQTNFKET 211

Human   310 ASFTEQWTDGFAFQNLVK---------------QQEWVNQQREDIERQ--------RKLLAKRKP 351
            ...|:..:..|...|.::               .|.:.::|||: .||        |:||.|.:.
Yeast   212 KRNTDYDSIDFGDLNPIQYIKKHNLPTSDLPLISQIYFDKQREE-NRQAALRKHSSRELLYKSRS 275

Human   352 PTA-----------NNSQAPSTNSEPKQRKNKAVNGAENDPFVRPNLPQLL-TLAEYHEQEEIFK 404
            .::           :||...:..|:|:::.:...:.:::...:|..|.:.: |....:....|.|
Yeast   276 SSSSLSSNNLLANKDNSITSNNGSQPRRKVSTGSSSSKSSIEIRRALKENIDTSNNSNFNSPIHK 340

Human   405 LRLGHLKKEEAEIQAELERLERVRNLHI-------------RELKR----------INNEDNSQF 446
            :..|..:.::    ::.|:.|.:||:.|             :.|||          ||:::...|
Yeast   341 IYKGISRNKD----SDSEKREVLRNISINANHADNLLQQENKRLKRSLDDAITNENINSKNLEVF 401

Human   447 KDHP----------------------------TLNE-RYLLLHLLGRGGFSEVYKAFDLYEQRYA 482
            ...|                            |:|: :|..:.||||||.|.|||......:.||
Yeast   402 YHRPAPKPPVTKKVEIVEPAKSASLSNNRNIITVNDSQYEKIELLGRGGSSRVYKVKGSGNRVYA 466

Human   483 AVKIHQLNKSWRDEKKENYHKHACREYRIHKEL-DHPRIVKLYDYFSLDTDTFCTVLEYCEGNDL 546
            ..::.  ..::.|...:.:.    .|..:.::| |..|:::|.|| .:.......::| |..:||
Yeast   467 LKRVS--FDAFDDSSIDGFK----GEIELLEKLKDQKRVIQLLDY-EMGDGLLYLIME-CGDHDL 523

Human   547 DFYLKQHKLM--SEKEARSIVMQIVNALRYLNEIKPPIIHYDLKPGNILLVDGTACGEIKITDFG 609
            ...|.|...|  .....|....:::..::.:::  ..|:|.||||.|.:||.|.    :||.|||
Yeast   524 SQILNQRSGMPLDFNFVRFYTKEMLLCIKVVHD--AGIVHSDLKPANFVLVKGI----LKIIDFG 582

Human   610 LSKIMDDDSYGVDGMDLTSQGAGTYWYLPPECFVVGKEPP-----------KISNKVDVWSVGVI 663
            ::..:.:.:..:    ......||..|:.||..|......           |:....|:||.|.|
Yeast   583 IANAVPEHTVNI----YRETQIGTPNYMAPEALVAMNYTQNSENQHEGNKWKVGRPSDMWSCGCI 643

Human   664 FFQCLYGRKPFGHNQSQQDILQENTILKATEVQFPVKPVVSSEAK------AFIRRCLAYRKED- 721
            .:|.:||:.|:|..|.|..:|    .:...:|:.|.....|:..|      ..::.|| ||..|
Yeast   644 IYQMIYGKPPYGSFQGQNRLL----AIMNPDVKIPFPEHTSNNEKIPKSAIELMKACL-YRNPDK 703

Human   722 RFDVHQLANDPYLLPHM 738
            |:.|.::.:..:|.|.|
Yeast   704 RWTVDKVLSSTFLQPFM 720

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TLK1	NP_036422.3	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..197		27/123 (22%)
		Smc	209..>454	CDD:224117	60/348 (17%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	346..383		6/47 (13%)
		STKc_TLK1	449..747	CDD:270942	81/340 (24%)
MPS1	NP_010256.2	PKc_Mps1	439..716	CDD:271033	75/299 (25%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C159052058
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.930