DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment TLK1 and mph1

DIOPT Version :9

Sequence 1:	NP_036422.3	Gene:	TLK1 / 9874	HGNCID:	11841	Length:	766	Species:	Homo sapiens
Sequence 2:	NP_595150.2	Gene:	mph1 / 2540060	PomBaseID:	SPBC106.01	Length:	678	Species:	Schizosaccharomyces pombe

Alignment Length:	678	Identity:	157/678 - (23%)
Similarity:	262/678 - (38%)	Gaps:	160/678 - (23%)

- Green bases have known domain annotations that are detailed below.

Human   170 SPQNSHSHST-PSSSVRPNSPSPTALAFGDHPIVQPKQLSFKIIQTDLTMLKLAALESNKIQDLE 233
            |.::|||..| ...::|..|...|||   :..:..|:..:|                     ||:
pombe    44 SSKSSHSDGTVTGDTLRRQSSGATAL---ERLVSHPRTKNF---------------------DLQ 84

Human   234 KKEGRIDDLLRANCDLRRQIDEQQKLLE------------KYKERLNKCISMSKKLLIEKSTQEK 286
            ...|:...|...|....:.:...:.|:.            .....:|...|.|:..|:.||..:.
pombe    85 GNGGQNSALKEVNTPAYQSMHHFEHLITPLPSTNASHSEVSLSAGVNDLNSNSEHDLLPKSVNKT 149

Human   287 LSSREKSMQDRL-RLGHFTTVRHGASFTEQWTDGFAFQNLVKQQEWVN--QQREDIERQRKLLAK 348
            ..|...|.:.|: |:|.....|...:.|:.          .|..:..|  :..||||     :..
pombe   150 PGSLSISRRRRIGRIGLGPPKRAEYTLTDP----------SKTSDTKNSTEADEDIE-----MKS 199

Human   349 RKPPTANNSQAPSTNSEPKQRKNKAVNGAENDPFVRPNLPQLLTLAEYH--EQEEIFKLRLGHLK 411
            |:...|:||.| :|..:|.|..|..:..::..|  :|:         :|  :.|..|..|:
pombe   200 REVSPASNSVA-ATTLKPLQLHNTPLQTSQEHP--KPS---------FHPSQFESSFSPRV---- 248

Human   412 KEEAEIQAELERLERVRNLHIR------ELKRINNE---------------DNSQFKDHP----- 450
                :...::||  |...||.|      |.:|..::               ||||....|
pombe   249 ----QFDHDVER--RASELHSRPVTVFQEPQRSASQPYESHALSPKVAPLFDNSQATPIPKRQQD 307

Human   451 ---TLNERYLLLHLLGRGGFSEVYKAFDLYEQR-YAAVKIHQLNKSWRDEKKENYHKHACREYRI 511
               ..|.:::.|.::|:||.|.||:.|.....| ||..:::.:|   .|:.....:|:   |..:
pombe   308 VVTVANLQFIKLGVVGKGGSSMVYRIFSPDNSRLYALKEVNFIN---ADQTTIQGYKN---EIAL 366

Human   512 HKELD-HPRIVKLYDYFSLDTDTFCTVLEYCEGNDLDFYLKQH--KLMSEKEARSIVMQIVNALR 573
            .::|. :.||:|||.....||.....::..|...||...|.::  |.::....|....|::.|::
pombe   367 LRKLSGNDRIIKLYAAEVNDTLGQLNMVMECGETDLANLLMKNMKKPINLNFIRMYWEQMLEAVQ 431

Human   574 YLNEIKPPIIHYDLKPGNILLVDGTACGEIKITDFGLSKIMDDDSYGVDGMDLTSQGAGTYWYLP 638
            .:::  ..|:|.||||.|.|||:    |.:|:.|||::|.:.:|:..:.    .....||..|:.
pombe   432 VVHD--QNIVHSDLKPANFLLVE----GNLKLIDFGIAKAIGNDTTNIH----RDSHIGTINYMA 486

Human   639 PECFV-------VGKEPPKISNKVDVWSVGVIFFQCLYGRKPFGHNQSQQDIL---QENTILKAT 693
            ||...       .|.:..|:....||||:|.|.:|.:|||.||.|.:..|.|.   .|...:...
pombe   487 PEALTDMNAHTNSGVKLVKLGRPSDVWSLGCILYQMVYGRAPFAHLKMIQAIAAIPNEQYHIHFP 551

Human   694 EVQFPVKPVVSSEAKA-----------FIRRCLAYRKEDRFDVHQLANDP-------YLLPHMRR 740
            ||..|...|...|...           .::|||...:..|..:.:|...|       ||.|..::
pombe   552 EVALPANAVQEKEGSLPGVTVGPDLMDVMKRCLERDQRKRLTIPELLVHPFLNPLPSYLTPLAKK 616

Human   741 ----SNSSGNLHMAGLTASPTPPSSSII 764
                |..:.|.|...|:...:....|:|
pombe   617 PLPVSGHTNNAHPLRLSTEISASQLSMI 644

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
TLK1	NP_036422.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..197		10/27 (37%)
		Smc	209..>454	CDD:224117	54/290 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	346..383		10/36 (28%)
		STKc_TLK1	449..747	CDD:270942	88/341 (26%)
mph1	NP_595150.2	PKc_Mps1	315..603	CDD:271033	82/303 (27%)
mph1	NP_595150.2	S_TKc	316..603	CDD:214567	82/302 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	100	1.000	Inparanoid score	I1880
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.050