DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment AREL1 and ptr1

DIOPT Version :9

Sequence 1:	NP_001034568.1	Gene:	AREL1 / 9870	HGNCID:	20363	Length:	823	Species:	Homo sapiens
Sequence 2:	NP_594902.1	Gene:	ptr1 / 2542537	PomBaseID:	SPAC19D5.04	Length:	3227	Species:	Schizosaccharomyces pombe

Alignment Length:	813	Identity:	212/813 - (26%)
Similarity:	342/813 - (42%)	Gaps:	223/813 - (27%)

- Green bases have known domain annotations that are detailed below.

Human   123 SNVVKVAFTVRKAGRYEITVKLGGLNVAYSPYYKIFQPGMVVPSKTKIVCHFSTLVLTCGQPHTL 187
            |||.|:|         .|.|.||.|     ...::|       ..|.::..||.|:.|..:| .|
pombe  2522 SNVYKIA---------PINVLLGLL-----AREELF-------GNTLVMNTFSELLSTLTKP-LL 2564

Human   188 QIVPRD--EYDNPTNNSMSLRDEHNYTLSIHELGPQEEESTGVS-FEKSVTS------------- 236
            .....:  :.|:.|....:.:|....|:      |:::..|..| .:|.:.|
pombe  2565 SFYKSEKLQKDSATTGYTNDQDSRGSTV------PKQDPGTTASRKDKKILSPPNILDENLRLAA 2623

Human   237 --------NRQTFQVFLRLTLHSRGCFHACISYQNQPINNGE-------FDIIVLSEDEKNIVER 286
                    :.:|||..|.:..|......|.|....:.:.:|:       .|:..|..|.|:  .:
pombe  2624 SLITTDSCSSRTFQNALSVMFHLSSIPKAKILIGKELLRHGQEYGNSITNDLSRLCADVKS--GK 2686

Human   287 NVSTSGVSIYFEAYLYNATNCSSTPWHLPPMHMTSS-----QRRPSTAVDEEDEDSP-------- 338
            |.|...|::        |..|.::......:....:     :|||     :..|.||
pombe  2687 NESELQVAL--------APFCPASSNQAKLLRCLKALDYIFERRP-----KGQEQSPGNIIQLLE 2738

Human   339 --------------SEC------HT---------------------------PEKVKKPKKVYCY 356
                          |||      ||                           ||.|.|      :
pombe  2739 FYDNLKFSSLWEVLSECLSALRDHTSITHVSTVLLPLIESLMVICRLVFIELPEDVGK------H 2797

Human   357 VSP--KQF-----SVKEFYLKIIPWRLYTFRVCPGTKFSYLGPDPVHKLLTLVVDDGIQPPVELS 414
            :||  ::|     |..|.:.|||...::|........||.|..:|  |:|
pombe  2798 ISPILERFKTLFISFTEEHRKIINMMVFTTPSLMSGSFSLLVKNP--KVL--------------- 2845

Human   415 CKERNILAATFIRSLHKNIGGSETFQDKVNFFQRELRQVHMKRPHSKVTLKVSRHALLESSLKAT 479
                                   .|::|.|:|.|:|.:...|..:..:.:.|.|..:...|.:|.
pombe  2846 -----------------------EFENKRNYFNRQLHEEAAKEQYPPLNITVRRDHVFLDSYRAL 2887

Human   480 RNFSISDWSK--NFEVVFQDEEALDWGGPRREWFELICKALFDTTNQLF-------TRFSDNNQA 535
             :|..:|..|  ...:.|:|||.:|.||..|||.:::.:.:|:....||       |.|..|..:
pombe  2888 -HFKDADEVKFSKLNIHFRDEEGVDAGGVTREWLQVLARQMFNPDYALFLPVTGDATTFHPNRDS 2951

Human   536 LVHPNPNRPAHLRLKMYEFAGRLVGKCLYESSLGGAYKQLVRARFTRSFLAQIIGLRMHYKYFET 600
            .|:|:       .|..::|.||::||.||:.       :|:...|:|:....::...:..|..|:
pombe  2952 SVNPD-------HLSFFKFTGRIIGKALYDG-------RLLDCHFSRAVYKHMLHRSVSVKDIES 3002

Human   601 DDPEFYKSKVCFILNNDMSE-MELVFAEEKYNKSGQLDKVVELMTGGAQTPVTNANKIFYLNLLA 664
            .||::|||.| ::||||::: :...||.|| :..|: ..||:|:..|...|||..||..|:|.:.
pombe  3003 LDPDYYKSLV-WMLNNDITDIITEEFAVEK-DVFGE-KTVVDLIPNGRNIPVTELNKQNYVNRMV 3064

Human   665 QYRLASQVKEEVEHFLKGLNELVPENLLAIFDENELELLMCGTGDISVSDFKAHAVVVGGSWHFR 729
            .|:|...||::::..|.|.::::|.:|:.||:|.|||||:.|..:|.:.|:|.:....|  ::..
pombe  3065 DYKLRESVKDQLKSLLDGFSDIIPSHLIQIFNEQELELLISGLPEIDIDDWKNNTEYHG--YNVS 3127

Human   730 EKVMRWFWTVVSSLTQEELARLLQFTTGSSQLPPGGFAAL--CPSFQII----AAPTHSTLPTAH 788
            ...::|||..|.|..:||.|:||||.||:|::|..||..|  ...||..    :..:.:.||.:|
pombe  3128 SPQVQWFWRAVRSFDEEERAKLLQFATGTSKVPLNGFKELEGMSGFQRFNIHKSYGSLNRLPQSH 3192

Human   789 TCFNQLCLPTYDSYEEVHRMLQLAISEGCEGFG 821
            ||||||.||.||:||::..||..||:||.||||
pombe  3193 TCFNQLDLPEYDTYEQLRSMLLTAINEGSEGFG 3225

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AREL1	NP_001034568.1	Filamin	52..158		10/34 (29%)
		Filamin	56..154	CDD:395505	10/30 (33%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	315..345		11/89 (12%)
		Interaction with SOCS2. /evidence=ECO:0000269\|PubMed:31578312	483..789		103/321 (32%)
		HECTc	486..820	CDD:214523	123/349 (35%)
ptr1	NP_594902.1	DUF908	96..367	CDD:283630
		DUF913	436..735	CDD:283642
		HARE-HTH	<1930..2018	CDD:294801
		DUF4414	2267..2347	CDD:291075
		HUL4	2314..3227	CDD:227354	212/813 (26%)
		HECTc	2870..3225	CDD:238033	129/374 (34%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11254
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	4	3.870