Protein Alignment SETDB1 and trx

DIOPT Version :10

• Sequence 1: NP_001353346.1
• Gene: SETDB1 / 9869
• HGNCID: 10761
• Length: 1292
• Species: Homo sapiens
• Sequence 2: NP_476769.1
• Gene: trx / 41737
• FlyBaseID: FBgn0003862
• Length: 3726
• Species: Drosophila melanogaster
• Alignment Length: 1921
• Identity: 305/1921 - (15%)
• Similarity: 558/1921 - (29%)
• Gaps: 842/1921 - (43%)

Human     7 CIGLDAATATVESEEI----AELQQAVVEEL------GISMEELRHFIDEELEKMDCVQQRKKQL 61
            |:..|..|.....::.    .||:.|:.|:|      ||||.::  |:.::...:..:.::.|
  Fly  2005 CVPPDENTEEEPQQQADLLPPELKDAIFEDLPHELLDGISMLDI--FLYDDKTDLFAISEQSK-- 2065

Human    62 AELETWVIQKESEVAHVDQLFDDASRAVTNCESLVKDFYSKLGLQYRDSSSEDESSRPTEIIEIP 126
                                  |.::|:|:                ..:.::::.:.....:.|.
  Fly  2066 ----------------------DGTQAMTS----------------NQAQNQNQQAGGANSVSIC 2092

Human   127 DEDDDVLSIDSGDAGSRTPKDQKLREAMAALRKSAQDVQKF-------MD-------AVNKKSSS 177
            |||   ....:...|:..|....:.:||.:..:::..||..       :|       |:.::..|
  Fly  2093 DED---TRNSNTSLGNGWPASNPVEDAMLSAARNSSQVQMLKTLAWPKLDGNSAMATAIKRRKLS 2154

Human   178 QDLHKG---TLS------------------QMSGELSKDGDLIVSMRILGKKRTK--TWHKGTLI 219
            ::|.:|   |||                  |...|.|.:|....|    |..|:|  ||
  Fly  2155 KNLAEGVFLTLSSQQRNKKEMATVAGVSRRQSISETSVEGVATTS----GSVRSKSFTW------ 2209

Human   220 AIQTVGPGKKYKVKFDNKGKS-------------------LLSG--------------------- 244
                 ...|:|..|.:.:.::                   ::||
  Fly  2210 -----SAAKRYFEKSEGREEAAKMRIMQMDGVDDSITEFRIISGDGNLSTAQFSGQVKCDRCQCT 2269

Human   245 --NHIAYDYHPPADKLYVGSRVVAKYKDGNQVWLYA-GIVAETPNVKNKLRFLIFFDDGYASYVT 306
              |:.|:..|.|:....:.|........|..:...| .|.||:   .|:|:..:..:.|..:|:.
  Fly  2270 YRNYDAFQRHLPSCSPTMSSNETESDVSGQGMTNNATQISAES---LNELQKQLLANAGGLNYLQ 2331

Human   307 QSELYP-------------------------------ICRPLKKTWEDIEDISCR---------- 330
            .:..:|                               :.:|...|..:.:|:...
  Fly  2332 SATSFPQVQSLGSLGQFGLQGLQQLQLQPQSLGSGFFLSQPNPATQANTDDLQIYANSLQSLAAN 2396

Human   331 -----DFIEEYVTAYPNRPMVLLKS------GQLIK--------TEWEGTWWKSRVEEVDGSLVR 376
                 ...:..||| |.:|.::..|      .|.|:        |....|:...:....|..::.
  Fly  2397 LGGGFTLAQPTVTA-PAQPQLIAVSTNPDGTQQFIQIPQTMQATTTPTATYQTLQATNTDKKIML 2460

Human   377 ILFLDDKRCEWIYRGSTRLEPMFSMKTSSASALEKKQGQLRTRPNMGAVRSK------------- 428
            .|....|             |:.::.|.:|.....||.||::...:..:::|
  Fly  2461 PLTAAGK-------------PLKTVATKAAQQAAVKQRQLKSGHQVKPIQAKLQPHPQQHQQQQQ 2512

Human   429 ----GPVVQYTQDL--------------------------------TGTGTQFKPVE-------- 449
                .|:....|:|                                ||.|:|.:|::
  Fly  2513 TQVQQPITVMGQNLLQPQLLFQSSTQTQAPQIILPQAQPQNIISFVTGDGSQGQPLQYISIPTAG 2577

Human   450 ----PPQPTAPPAPPFPPAPP------------------LSPQAGDSESLESQLAQSRKQVAKKS 492
                .|||||  .|.|....|                  .:|.....:.|.:|..|::.||.  .
  Fly  2578 EYKPQPQPTA--TPTFLTTAPGAGATYLQTDASGNLVLTTTPSNSGLQMLTAQSLQAQPQVI--G 2638

Human   493 TSFRP-------GSVGSGHSSPTSPALSENVSGGKPGINQTYRSPLGSTASAP------------ 538
            |..:|       |:.|:...|...|.:.....||..|:.....||....|:.|
  Fly  2639 TLIQPQTIQLGGGADGNQPGSNQQPLILGGTGGGSSGLEFATTSPQVILATQPMYYGLETIVQNT 2703

Human   539 -------APSALPAPPAPPVFHGMLERAPAEPSYRAPMEKLFYLPHV-------CSYTCL----- 584
                   ..:|:|         |||.:   ..|:.|...::|....:       ..|..|
  Fly  2704 VMSSQQFVSTAMP---------GMLSQ---NASFSATTTQVFQASKIEPIVDLPAGYVVLNNTGD 2756

Human   585 -----------------------SRVRPMRNEQYRG-------------KNPLLV----PLLYDF 609
                                   :::....|.|::.             .:|::|    |.:...
  Fly  2757 ASSAGTFLNAASVLQQQTQDDTTTQILQNANFQFQSVPTSSGASTSMDYTSPVMVTAKIPPVTQI 2821

Human   610 RRMTARRR----------------VNRKMGFHVIYK-------------------------TPCG 633
            :|..|:.:                ||:.:...::.:                         |.||
  Fly  2822 KRTNAQAKAAGISGVGKVPPQPQVVNKVLPTSIVTQQSQVQVKNSNLKQSQVKGKAASGTGTTCG 2886

Human   634 ----LCLRTMQEIERYLFETGCDFLFLEMFCLDPYVLVDRKFQPYKPFYYILDITYG-------- 686
                :..:.:|:               :...:.|...::.|.:..||...:.:..:.
  Fly  2887 APPSIASKPLQK---------------KTNMIRPIHKLEVKPKVMKPTPKVQNQNHSLLQQQQQQ 2936

Human   687 ----KEDVPLSCVNEIDTTPPPQVAYSKERIPGKGVFINTGPEFLVGCDCKDGCRDKSKCACHQL 747
                ::.:|...||::     |:|..|::|||.:     |..:.|.........:.:......|:
  Fly  2937 QPQLQQQIPAVVVNQV-----PKVTISQQRIPAQ-----TQQQQLQQAQMIHIPQQQQPLQQQQV 2991

Human   748 TIQAT------ACTPGGQ----INPNSGYQYK---RLEECLPTGVYECNKRCKCDPNMC------ 793
            .:|.:      |..|..|    :.|.:..|.:   |::. ..|.....:..|....|:.
  Fly  2992 QVQPSMPIITLAEAPVVQSQFVMEPQALEQQELANRVQH-FSTSSSSSSSNCSLPTNVVNPMQQQ 3055

Human   794 ------------TNRLVQHGLQVRLQLFKTQNKGWGIRC----------------LDDIAKGSFV 830
                        |||::.  :|.|.:.....|:     |                :..:...|..
  Fly  3056 APSTTSSSTTRPTNRVLP--MQQRQEPAPLSNE-----CPVVSSPTPPKPVEQPIIHQMTSASVS 3113

Human   831 CIYAGKILTDDFADKEGLEMG------------DEYFANLDHIESVENFKEG-YESDAPCSSDSS 882
            ..||.|........:..|::.            |.........||:  :.|| ||.::|..|.:.
  Fly  3114 KCYAQKSTLPSPVYEAELKVSSVLESIVPDVTMDAILEEQPVTESI--YTEGLYEKNSPGESKTE 3176

Human   883 GVDLKDQEDG-------NSG-------------------TEDPEESNDDSSDDNFCKDEDFSTSS 921
            .:.|:.|:..       |:|                   .||.||..|:        |:|||
  Fly  3177 QLLLQQQQREQLNQQLVNNGYLLDKHTFQVEPMDTDVYREEDLEEEEDE--------DDDFS--- 3230

Human   922 VWRSYATRRQTRGQKENGLSETTSKDSHPPDLGPPHIPVPPSIPVGGCN----PPSSEETPKNKV 982
                              |...||                      .||    ..|.|...|:|:
  Fly  3231 ------------------LKMATS----------------------ACNDHEMSDSEEPAVKDKI 3255

Human   983 ASWLS-------CNSVSEGGFADSDSHSSFK---------------TNEGGEGRAGGSRMEA--- 1022
            :..|.       .:|::.....:.|:.:.::               ..|..||....:.:||
  Fly  3256 SKILDNLTNDDCADSIATATTMEVDASAGYQQMVEDVLATTAAQSAPTEEFEGALETAAVEAAAT 3320

Human  1023 ---EKASTSGLGIKD-----EGDIKQAKKE-----DTDDRNKMSVVTESSRNYGYNPSPVKPEGL 1074
               |.|....|.:|.     |.::::.|:|     ...:::|.::|..::       :|..|:.:
  Fly  3321 YINEMADAHVLDLKQLQNGVELELRRRKEEQRTVSQEQEQSKAAIVPTAA-------APEPPQPI 3378

Human  1075 RRPPSKTSMHQSRRLMASAQSNPDDVLTLSSSTESE----------------GESGTSRKPTA-- 1121
            :.|...|..|    |:...||  :|..|..||:.:|                |.:.....|.|
  Fly  3379 QEPKKMTGPH----LLYEIQS--EDGFTYKSSSITEIWEKVFEAVQVARRAHGLTPLPEGPLADM 3437

Human  1122 ----------------------------------------------------GQTSATAVDS--- 1131
                                                                |.:||:|..|
  Fly  3438 GGIQMIGLKTNALKYLIEQLPGVEKCSKYTPKYHKRNGNVSTAANGAHGGNLGGSSASAALSVSG 3502

Human  1132 -DDIQTISSGSEGDDFED------------------------KKNMTGPMKRQVAVKST------ 1165
             |....:..||:.|:.|:                        .::...|:  ||.|:.:
  Fly  3503 GDSHGLLDYGSDQDELEENAYDCARCEPYSNRSEYDMFSWLASRHRKQPI--QVFVQPSDNELVP 3565

Human  1166 -RGF-----------ALKST------------HGIAIKSTNMASVDKGE----------SAPVRK 1196
             ||.           .||.|            ||..:..|.  .::.||          .:.:..
  Fly  3566 RRGTGSNLPMAMKYRTLKETYKDYVGVFRSHIHGRGLYCTK--DIEAGEMVIEYAGELIRSTLTD 3628

Human  1197 NTRQFYDGEE-SCY--------IIDAKLEGNLGRYLNHSCSPNLFVQNVFVDTHDLRFPWVAFFA 1252
            ...::||... .||        ::||.:.||..|::||.|.||.:.:.|.:..|    ..:..||
  Fly  3629 KRERYYDSRGIGCYMFKIDDNLVVDATMRGNAARFINHCCEPNCYSKVVDILGH----KHIIIFA 3689

Human  1253 SKRIRAGTELTWDYNYEVGSVEGKELLCCCGAIECR 1288
            .:||..|.|||:||.:   ..|.:::.|.||:..||
  Fly  3690 LRRIVQGEELTYDYKF---PFEDEKIPCSCGSKRCR 3722

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SETDB1	NP_001353346.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	108..147		6/38 (16%)
		DUF5604	193..250	CDD:408109	15/100 (15%)
		Tudor_SETDB1_rpt1	260..341	CDD:410453	17/127 (13%)
		Tudor_SETDB1_rpt2	348..401	CDD:410548	9/66 (14%)
		MBD	598..673	CDD:128673	13/123 (11%)
		SET_SETDB1	675..>876	CDD:380915	43/272 (16%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	869..1161		73/458 (16%)
		SET	<1203..1292	CDD:394802	31/95 (33%)
trx	NP_476769.1	NR_DBD_like	762..>856	CDD:413390
		PRK13914	<1006..>1224	CDD:237555
		PHD1_KMT2A_like	1268..1344	CDD:276981
		PHD	1346..1390	CDD:214584
		PHD3_KMT2A_like	1423..1479	CDD:276983
		ePHD_KMT2A_like	1737..1841	CDD:277134
		FYRN	1890..1937	CDD:461787
		FYRC	3388..3476	CDD:197781	12/93 (13%)
		SET_KMT2A_2B	3575..3726	CDD:380947	40/157 (25%)