Protein Alignment SETDB1 and ash1

DIOPT Version :10

• Sequence 1: NP_001353346.1
• Gene: SETDB1 / 9869
• HGNCID: 10761
• Length: 1292
• Species: Homo sapiens
• Sequence 2: NP_524160.2
• Gene: ash1 / 40133
• FlyBaseID: FBgn0005386
• Length: 2226
• Species: Drosophila melanogaster
• Alignment Length: 1440
• Identity: 275/1440 - (19%)
• Similarity: 439/1440 - (30%)
• Gaps: 563/1440 - (39%)

Human    12 AATATVESEEIAELQQAVVEELGISMEELRHFIDEELEKMDCVQQRKKQLAELETWVIQKESEVA 76
            :|..|||.::|.:|...   .||.|.||...:|.:...|........|:..|:..:|.
  Fly   489 SADDTVEDQDILQLAGL---SLGQSSEESNEYISKPSLKSLPTTSASKKYGEINRYVT------- 543

Human    77 HVDQLFD-DASRAVTNCESLVKDFYSKLGLQYRDSSSEDESSRPTEIIEIPDEDDDVLSIDSGDA 140
             ..|.|. ..|.:.||.:    :|.||:..|.:::.:..:||
  Fly   544 -TGQYFGRGGSLSATNPD----NFISKMMNQRKETPAPSKSS----------------------- 580

Human   141 GSRTPKDQKLREAMAALRKS-AQDVQKFMDAVNKKSSSQDLHKGTLSQMSGELSKDGDLIVSMRI 204
                .|.:..|.:.|::..| ...|.:......:||.|.          :..|:.|..|:..:.|
  Fly   581 ----CKIKSRRSSAASMCSSYVSGVSRMRRRHRRKSFSH----------NKSLNIDSKLLTEIEI 631

Human   205 LGKKRTKTWHKGTLIAIQTVGPGKKYKVKFDNKGKSLLSGNHIAYDYHPPADKLYVGSRVVAKYK 269
            :    |.|::             .:.:::.|.     |:|:       ...:||..
  Fly   632 I----TSTFN-------------SRCRIQDDR-----LTGS-------SGKEKLLA--------- 658

Human   270 DGNQVWLYAGIVAETPNVKNKLRFLIFFDDGYASYVTQSELYPICRPLKKTWEDIEDISCRDFIE 334
            |.|:  |.|.:.|.:|     .:.|.....|.||.:::    |:.|.|||          |...|
  Fly   659 DANK--LQATLAAPSP-----AQQLTLNGGGPASTLSK----PLKRGLKK----------RKLSE 702

Human   335 EYVTAYPNRPMVLLKSGQLIKTEWEGTWWKSRVEEVDGSLVRILFLDDKRCEWIYRGSTRLEPMF 399
                     |:|   ...::.....||      ....||               ..|:|:.....
  Fly   703 ---------PLV---DFAMLSASASGT------PNGSGS---------------SNGNTKRRHKK 734

Human   400 SMKTSSASALE-----KKQGQLRT---RPNMGAVRSKGPVVQYTQDLTGTGTQFKPVEPPQPTAP 456
            |....|:|..:     ||:..|.|   ||......:.|                 .:......|.
  Fly   735 SQSNDSSSPDDHKLPLKKRHYLLTPGERPPAEVAFANG-----------------KLNAEAWAAA 782

Human   457 PAPPFPPAPPLSPQAGDSESLESQLAQSRKQVAKKSTSFRPGSVGSGHSSPTSPAL----SENVS 517
            .|.....|...|....::.|::|.|...::.:.::.||..    |:|.|:..||..    :.::|
  Fly   783 AAAAKSTASTKSQAQFNARSVKSALTPKKRHLLEQPTSVS----GAGSSASNSPLRIVVDNNSIS 843

Human   518 GGK-----P----GINQTYRSPLGSTASAPAPSA-----LPAP----PAPPVFHGMLERAPAEPS 564
            |||     |    .:.|..|   |..|.....:|     |.:|    |.|.||         |||
  Fly   844 GGKLLDISPSSLCSLKQQRR---GGAAKQKVSAAKDLVQLQSPAGSYPPPGVF---------EPS 896

Human   565 ----YRAPMEKLFYLPHVCSYTCLSRVRPMRNEQYRGKNPLLVPLL--YDFRRMTARRRVNRKMG 623
                .:.|:.||                   ||....|..:..|||  .|.:..| ::.|.:::.
  Fly   897 VELEIQIPLSKL-------------------NESVITKAEVESPLLSALDIKEDT-KKEVGQRVV 941

Human   624 FHVIYKTPCGLCL-RTMQEIERYLFETGCDFLFLEMFCLDPYVLVDRK-------------FQPY 674
            ..:::||...|.| |..::|.|..|.|                 |.||             ...:
  Fly   942 ETLLHKTGGNLLLKRKRKKINRTGFPT-----------------VRRKKRKVSVEQQTTAVIDEH 989

Human   675 KPFYYILDITYGKEDVPLSCV------NEIDTTPPPQVAYSKERIPGKGVFINTGPEFLVGCDCK 733
            :|       .:..:|.||..:      |.::....|......||:|..|....|   |:...:.|
  Fly   990 EP-------EFDPDDEPLQSLRETRSSNNVNVQAAPNPPLDCERVPQAGEARET---FVARTNQK 1044

Human   734 DGCRDKSKCACHQLTIQATAC--TPGG---------------------QINP--NSGYQYKR--L 771
              ....|..|..:|....|..  .|.|                     :|.|  ..|.|.|:  |
  Fly  1045 --APRLSVVALERLQRPQTPARGRPRGRKPKNREQAEAAPQPPPKSEPEIRPAKKRGRQPKQPVL 1107

Human   772 EECLPTGVYECNKRCKCDPNMCTNRLVQHGLQVRLQLFKTQNKGWGIRCLDDIAKGSFVCIYAGK 836
            ||..||...: .|:.|.:||            :||.
  Fly  1108 EEPPPTPPPQ-QKKNKMEPN------------IRLP----------------------------- 1130

Human   837 ILTDDFADKEGLEMGDEYFANLDHIESVENFKEGYESDAPCSSDSSGVDLKDQEDGNSGTEDPEE 901
                                  |.|:...||             |..:.||.:::..:||:.
  Fly  1131 ----------------------DGIDPNTNF-------------SCKIRLKRRKNLEAGTQP--- 1157

Human   902 SNDDSSDDNFCKDEDFSTSSVWRSYATRRQTRGQKENGLSETTSKDSHPPDLGPPHIPVPPSIPV 966
                                             :||..:...|.::            :||.|||
  Fly  1158 ---------------------------------KKEKPVQPVTVEE------------IPPEIPV 1177

Human   967 GGCNPPSSEETPKNKVASWLSCNSVSEGGFADSDSHSSFKTNEGGEGRAGGSRMEAEKASTSGLG 1031
                  |.||......|..|............|:||     |.|.:..|..|....:||||:.|.
  Fly  1178 ------SQEEIDAEAEAKRLDSIPTEHDPLPASESH-----NPGPQDYASCSESSEDKASTTSLR 1231

Human  1032 IKDEGDIKQAKKEDT-------DDRNKMSVVTESSRNYGYNPSP-----VKPEGLRRPPSKTSMH 1084
                   |.:|.:.|       .:..|.|::...::   .|..|     |.|..|..||.....:
  Fly  1232 -------KLSKVKKTYLVAGLFSNHYKQSLMPPPAK---VNKKPGLEEQVGPASLLPPPPYCEKY 1286

Human  1085 QSRRLMASAQSNPDDVLTLSSSTESEGESGTSRKPTAGQTSA-------TAVDSDDIQ------- 1135
            ..|..|..  ..|.|:....::         |:.||.....:       |.|.::.::
  Fly  1287 LRRTEMDF--ELPYDIWWAYTN---------SKLPTRNVVPSWNYRKIRTNVYAESVRPNLAGFD 1340

Human  1136 --TISSGSEGDDFEDKKNMTGPMKRQV----------AVKSTRGFALKSTHGIAIKSTNMASVDK 1188
              |.:..::|    :|..:...:.|.|          |.:..|...:: .|.:|.......:.||
  Fly  1341 HPTCNCKNQG----EKSCLDNCLNRMVYTECSPSNCPAGEKCRNQKIQ-RHAVAPGVERFMTADK 1400

Human  1189 G----ESAPVRKNT------------RQFYDGEESCY---------------IIDAKLEGNLGRY 1222
            |    ...|:.|.|            ::|.....|.|               :||.:..|:..|:
  Fly  1401 GWGVRTKLPIAKGTYILEYVGEVVTEKEFKQRMASIYLNDTHHYCLHLDGGLVIDGQRMGSDCRF 1465

Human  1223 LNHSCSPNLFVQNVFVDTHDLRFPW-------VAFFASKRIRAGTELTWDYNYEV-GSVEGKELL 1279
            :||||.||..:|.           |       :..||.:.|..|.|||:|||:.: ...||:.
  Fly  1466 VNHSCEPNCEMQK-----------WSVNGLSRMVLFAKRAIEEGEELTYDYNFSLFNPSEGQP-- 1517

Human  1280 CCCGAIECRG 1289
            |.|...:|||
  Fly  1518 CRCNTPQCRG 1527

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SETDB1	NP_001353346.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	108..147		2/38 (5%)
		DUF5604	193..250	CDD:408109	8/56 (14%)
		Tudor_SETDB1_rpt1	260..341	CDD:410453	17/80 (21%)
		Tudor_SETDB1_rpt2	348..401	CDD:410548	6/52 (12%)
		MBD	598..673	CDD:128673	19/90 (21%)
		SET_SETDB1	675..>876	CDD:380915	39/233 (17%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	869..1161		56/329 (17%)
		SET	<1203..1292	CDD:394802	31/110 (28%)
ash1	NP_524160.2	PHA03247	<1018..1281	CDD:223021	75/413 (18%)
		AWS	1340..1388	CDD:197795	8/52 (15%)
		SET_ASH1L	1391..1531	CDD:380951	38/150 (25%)
		Bromo_ASH1	1680..1787	CDD:99955
		PHD_ASH1L	1858..1900	CDD:277023
		BAH_polybromo	1929..2073	CDD:240068