back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SETDB1 and egg

DIOPT Version :9

Sequence 1:	NP_001353346.1	Gene:	SETDB1 / 9869	HGNCID:	10761	Length:	1292	Species:	Homo sapiens
Sequence 2:	NP_611966.3	Gene:	egg / 37962	FlyBaseID:	FBgn0086908	Length:	1262	Species:	Drosophila melanogaster

Alignment Length:	1381	Identity:	402/1381 - (29%)
Similarity:	577/1381 - (41%)	Gaps:	448/1381 - (32%)

- Green bases have known domain annotations that are detailed below.

Human     8 IGLDAATATVESEEIAELQQAVVEELGISMEELRHFIDEELEKMDCVQQRKKQ-LAELET----W 67
            :.|:..||...:|:         |:|...:.:...|.|:|....:|.:..|:. ||.:.|    .
  Fly   234 VELEKGTAPKAAED---------EKLNALLSDGDVFYDKECVNCNCTKLHKQYVLANMATLNFYQ 289

Human    68 VIQKESEV------AH---VDQLFDDASRAVTNCESLVKDFYSK----LGLQYRDSSSEDESSRP 119
            |::|.|:.      .|   :|...:.|.:.:.....|:|||:..    :.|   |||.|:|..:.
  Fly   290 VLRKSSKQQFLCMGCHDTAMDLYEEYAGQLMAKQPLLLKDFHQDHADFVAL---DSSDEEEEEKQ 351

Human   120 TEIIE--------IPDEDDDVLS--IDSGDAGSRTPKDQKLREAMA------------ALRKSAQ 162
            .|..:        |.||.||.:.  ::..|..::....:.:.:|.|            .|.|...
  Fly   352 PEKSDFSKNKLQLIEDELDDAIKNVLNKVDFTAQLSWSKTILQAKADHLERQFALADVELEKVQT 416

Human   163 DVQKFMDAVNKKSSSQDLHKGTL----SQMSGELSKDGDLIVSMRILGK-------KRTKTW--- 213
            ...|...|:.........|..||    |....|:...|:::.....||:       |...:|
  Fly   417 TADKMHCALYNSCPVAHKHLPTLDIEPSDYVHEVPPPGEIVRPPIQLGETYYAVKNKAIASWVSI 481

Human   214 -----HKGTLIAIQTVGPGKKYKVKFDNKGKSLL---SGNHIAYDYHPPADKLYVGSRVVAKYKD 270
                 .:.|.|...|:   |.||:::.|....::   :..|||| :.||..:|.:|:||:| |.|
  Fly   482 KVIEFTESTAINGNTM---KSYKIRYLNTPYQMIKTVTAKHIAY-FEPPPVRLTIGTRVIA-YFD 541

Human   271 GN-----------QVWLYAGIVAETPNVKNKLRFLIFFDDGYASYVTQSELYPICRPLKKTWEDI 324
            |.           |...|.||:||.....|:.|:|||:||||..||...::..:|:..:|.|||:
  Fly   542 GTTLSRGKDKGVVQSAFYPGIIAEPLKQANRYRYLIFYDDGYTQYVPHRDVRLVCQASEKVWEDV 606

Human   325 EDISCRDFIEEYVTAYP-NRPMVLLKSGQLIKTEWEGTWWKSRVEEVDGSLVRILFLDDK-RCEW 387
            ...| ||||::||..|. :||||....||.:.||..|||..:||.::|.|||.:.|..|| ..||
  Fly   607 HAAS-RDFIQKYVEKYSVDRPMVQCTRGQSMTTESNGTWLYARVIDIDCSLVLMQFEGDKNHTEW 670

Human   388 IYRGSTRLEPMF-----SMKTSSASALEKKQGQLRTRPNMGAVRSKGPVVQYTQDLTGTGTQFKP 447
            |||||.||.|:|     :|.:|||.       |||      ..|...|.::||:::..:
  Fly   671 IYRGSLRLGPVFRETQNNMNSSSAQ-------QLR------VPRRTEPFIRYTKEMESS------ 716

Human   448 VEPPQPTAPPAPPFPPAPPLSPQAGDSESLESQLAQSRKQVAKKSTSFRPGSVGSGHSSPTSPAL 512
                                           |::.|..:..|:||::....:..:..||..:||
  Fly   717 -------------------------------SKVNQQMRAFARKSSASAQNNALAAASSAATPA- 749

Human   513 SENVSGGKPGINQTYRSPLGSTASAPAPSALPAPPAPPVFHGMLERAPAEPSYRAPMEKL---FY 574
                 ||        |:..|..:::.:.||:.......::.....|......|......|   .|
  Fly   750 -----GG--------RTNAGGVSTSNSASAVRHLNNSTIYVDDENRPKGHVVYFTAKRNLPPKMY 801

Human   575 LPHVCSYTCLSRVRPMRNEQYRGKNPLLVPLLYDFRRMTARRRVNRKMGFHVIYKTPCGLCLRTM 639
            ..|.||..||.:: ..|.:.|   :||..|||..:.|:..|::..:.    |:||.|||..||::
  Fly   802 KCHECSPNCLFKI-VHRLDSY---SPLAKPLLSGWERLVMRQKTKKS----VVYKGPCGKSLRSL 858

Human   640 QEIERYL-----------FETGCDFLFLEMFCLDPYVLVDRKFQPYKPFYYILDITYGKEDVPLS 693
            .|:.|||           |:...|...|..:.:||.::.|            .||:.|:|.:.:.
  Fly   859 AEVHRYLRATENVLNVDNFDFTPDLKCLAEYSIDPSIVKD------------TDISKGQEKMAIP 911

Human   694 CVNEIDTTPPPQVAYSKERIPGKGVFINTGPEFLVGCDCKDGCRDKSKCACHQLTIQATA-CTPG 757
            .||..|.|.||...|:|:|||.:||.:|...|||:.|||:|.|.|||||||.|||:.... |.|.
  Fly   912 LVNYYDNTLPPPCTYAKQRIPTEGVHLNLDEEFLLCCDCEDDCSDKSKCACWQLTVAGVRYCNPK 976

Human   758 GQINPNSGYQYKRLEECLPTGVYECNKRCKCDPNMCTNRLVQHGLQVRLQLFKTQNKGWGIRCLD 822
            ..|. ..|||||||.|.:|||:||||.||||..| |.||:||..|:::||:|||.|:|||:||::
  Fly   977 KPIE-EIGYQYKRLHEHVPTGIYECNSRCKCKKN-CLNRVVQFSLEMKLQVFKTSNRGWGLRCVN 1039

Human   823 DIAKGSFVCIYAGKILTDDFADKEGLEMGDEYFANLDHIESVENFKEGYESDAPCSSDSSGVDLK 887
            ||.||:|:|||||.:||:..|::.|.:.||||||:||:||..|..||||||:.
  Fly  1040 DIPKGAFICIYAGHLLTETMANEGGQDAGDEYFADLDYIEVAEQLKEGYESEV------------ 1092

Human   888 DQEDGNSGTEDPEESNDDSSDDNFCKDEDFSTSSVWRSYATRRQTRGQKENGLSETTSKDSHPPD 952
                        :.|:.|:.:||
  Fly  1093 ------------DHSDPDAEEDN------------------------------------------ 1103

Human   953 LGPPHIPVPPSIPVGGCNPPSSEETPKNKVASWLSCNSVSEGGFADSDSHSSFKTNEGGEGRAGG 1017
                          ||   |.:
  Fly  1104 --------------GG---PDA------------------------------------------- 1108

Human  1018 SRMEAEKASTSGLGIKDEGDIKQAKKEDTDDRNKMSVVTESSRNYGYNPSPVKPEGLRRPPSKTS 1082
                                      ||.||               :.|               :
  Fly  1109 --------------------------EDDDD---------------FRP---------------N 1117

Human  1083 MHQSRRLMASAQSNPDDVLTLSSSTESEGESGTSRKPTAGQTSATAVDSDDIQTISSGSEGDDFE 1147
            .|..|::..|::|..    |.:|||:|                 :.:||.:...|:.....|
  Fly  1118 YHYQRKIKRSSRSGS----TQNSSTQS-----------------SELDSQERAVINFNPNAD--- 1158

Human  1148 DKKNMTGPMKRQVAVKSTRGFALKSTHGIAIKSTNMASVDKGESAPVRKNT-RQFYDGEESCYII 1211
                                  |..|                    ||:|: |:.:..:|:.||:
  Fly  1159 ----------------------LDET--------------------VRENSVRRLFGKDEAPYIM 1181

Human  1212 DAKLEGNLGRYLNHSCSPNLFVQNVFVDTHDLRFPWVAFFASKRIRAGTELTWDYNYEVGSVEGK 1276
            |||..||||||.||||||||||||||||||||||||||||::..||:||||||:||||||.|.||
  Fly  1182 DAKTTGNLGRYFNHSCSPNLFVQNVFVDTHDLRFPWVAFFSAAHIRSGTELTWNYNYEVGVVPGK 1246

Human  1277 ELLCCCGAIECRGRLL 1292
            .|.|.|||..||.|||
  Fly  1247 VLYCQCGAPNCRLRLL 1262

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.