Protein Alignment TOMM70 and TOM71

DIOPT Version :10

• Sequence 1: NP_055635.3
• Gene: TOMM70 / 9868
• HGNCID: 11985
• Length: 608
• Species: Homo sapiens
• Sequence 2: NP_011985.1
• Gene: TOM71 / 856517
• SGDID: S000001159
• Length: 639
• Species: Saccharomyces cerevisiae
• Alignment Length: 619
• Identity: 156/619 - (25%)
• Similarity: 266/619 - (42%)
• Gaps: 88/619 - (14%)

Human    41 LALAVGAPLLLGAGAIYLWSRQQRRREARGRGD------------------------ASG----- 76
            ||........:||...|...:||::::.:|..|                        .||
Yeast    18 LATVSAGTAAVGAYVYYQQIKQQQQQQLKGTKDNRRQSEAFAGQNEDEADLKDDGSVVSGSNKRK 82

Human    77 -----LKRNSERKTPEGRASPAPGSGHPEGPGAHLDMNSLDRAQA----AKNKGNKYFKAGKYEQ 132
                 .|||::.|:.||...|:..:|.|:  .|.|...|..:.||    .||:||.:|.|..:.:
Yeast    83 KKKNKRKRNNKAKSGEGFDYPSLPNGEPD--IAQLKGLSPSQRQAYAVQLKNRGNHFFTAKNFNE 145

Human   133 AIQCYTEAISLCPTEKNVDLSTFYQNRAAAFEQLQKWKEVAQDCTKAVELNPKYVKALFRRAKAH 197
            ||:.|..||.|.|.|     ..||.|.:|.:......::|.:..|||:|:.|.:.|||.|||.|:
Yeast   146 AIKYYQYAIELDPNE-----PVFYSNISACYISTGDLEKVIEFTTKALEIKPDHSKALLRRASAN 205

Human   198 EKLDNKKECLEDVTAVCILEGFQNQ--QSML---LADKVLKLLGKEKAKEKYKNREPLMPSPQFI 257
            |.|.|..:.:.|::.:.:...|...  :.||   |..:.:|:|.:..:|::.:..: ::||...:
Yeast   206 ESLGNFTDAMFDLSVLSLNGDFDGASIEPMLERNLNKQAMKVLNENLSKDEGRGSQ-VLPSNTSL 269

Human   258 KSYFSSFTDDIISQPMLKGEKSDEDKDKEGEALE---VKENSGYLKAKQYMEE--ENYDKIISEC 317
            .|:|..|...:....:......|.......:||:   ...:.|||.|...:.:  :.|..::|..
Yeast   270 ASFFGIFDSHLEVSSVNTSSNYDTAYALLSDALQRLYSATDEGYLVANDLLTKSTDMYHSLLSAN 334

Human   318 SKEIDAEGKYMAEALLLRATFYLLIGNANAAKPDLDKVISLKEA-NVKLRANALIKRGSMYMQQQ 381
            :.: |...:..|.||.....|:.|..|.      ||..:.|:|: |:....|:.|........::
Yeast   335 TVD-DPLRENAALALCYTGIFHFLKNNL------LDAQVLLQESINLHPTPNSYIFLALTLADKE 392

Human   382 QPLLSTQDFNMAADIDPQNADVYHHRGQLKILLDQVEEAVADFDECIRLRPESALAQAQKCFALY 446
            ......:.|..|.|::|:....|:||||:..:|...:.|..||.:...|.||:.....|....||
Yeast   393 NSQEFFKFFQKAVDLNPEYPPTYYHRGQMYFILQDYKNAKEDFQKAQSLNPENVYPYIQLACLLY 457

Human   447 RQA-YTGNNSSQIQAAMKGFEEVIKKFPRCAEGYALYAQALTDQQQFGKADEMYDKCIDLEPDNA 510
            :|. :|.:.:.        |.|...|||...|....:|:.|||:..|..|.:.||....||....
Yeast   458 KQGKFTESEAF--------FNETKLKFPTLPEVPTFFAEILTDRGDFDTAIKQYDIAKRLEEVQE 514

Human   511 TTYVHKG-------LLQLQWKQD---LDR-----GLELISKAIEIDNKCDFAYETMGTIEVQRGN 560
            ..:|..|       :|..|..||   ||.     .::|::||.|:|.:.:.|...:..:::|...
Yeast   515 KIHVGIGPLIGKATILARQSSQDPTQLDEEKFNAAIKLLTKACELDPRSEQAKIGLAQLKLQMEK 579

Human   561 MEKAIDMFNKAINLAKSEMEMAHLYSLCDAAHAQ 594
            :::||::|..:..||::..|.....:..:||..|
Yeast   580 IDEAIELFEDSAILARTMDEKLQATTFAEAAKIQ 613

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TOMM70	NP_055635.3	3a0801s09	41..601	CDD:273380	156/619 (25%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	67..107		14/73 (19%)
		TPR 1	114..147		15/36 (42%)
		TPR repeat	114..142	CDD:276809	12/31 (39%)
		TPR repeat	152..182	CDD:276809	8/29 (28%)
		TPR 2	153..186		10/32 (31%)
		TPR 3	294..327		7/34 (21%)
		TPR 4	329..362		10/33 (30%)
		TPR repeat	329..357	CDD:276809	8/27 (30%)
		TPR repeat	362..396	CDD:276809	5/33 (15%)
		TPR 5	367..400		6/32 (19%)
		TPR 6	401..434		11/32 (34%)
		TPR repeat	401..429	CDD:276809	9/27 (33%)
		TPR repeat	435..470	CDD:276809	7/35 (20%)
		TPR 7	440..475		10/35 (29%)
		TPR 8	476..509		11/32 (34%)
		TPR repeat	476..504	CDD:276809	9/27 (33%)
		TPR repeat	509..540	CDD:276809	11/45 (24%)
		TPR 9	511..544		13/47 (28%)
		TPR 10	545..578		7/32 (22%)
		TPR repeat	545..572	CDD:276809	5/26 (19%)
TOM71	NP_011985.1	3a0801s09	9..636	CDD:273380	156/619 (25%)
		TPR repeat	127..155	CDD:276809	10/27 (37%)
		TPR repeat	160..190	CDD:276809	9/34 (26%)
		TPR repeat	195..218	CDD:276809	10/22 (45%)
		TPR repeat	345..373	CDD:276809	10/33 (30%)
		TPR repeat	378..406	CDD:276809	4/27 (15%)
		TPR repeat	411..441	CDD:276809	9/29 (31%)
		TPR repeat	446..471	CDD:276809	6/32 (19%)
		TPR repeat	480..508	CDD:276809	9/27 (33%)
		TPR repeat	513..559	CDD:276809	11/45 (24%)
		TPR repeat	564..588	CDD:276809	4/23 (17%)