Protein Alignment TOMM70 and TOM70

DIOPT Version :10

• Sequence 1: NP_055635.3
• Gene: TOMM70 / 9868
• HGNCID: 11985
• Length: 608
• Species: Homo sapiens
• Sequence 2: NP_014278.3
• Gene: TOM70 / 855602
• SGDID: S000005065
• Length: 617
• Species: Saccharomyces cerevisiae
• Alignment Length: 630
• Identity: 156/630 - (24%)
• Similarity: 271/630 - (43%)
• Gaps: 111/630 - (17%)

Human    43 LAVGAPLLLGAGAIYLWSRQQRRREARGR-----GDASGLKRNSERKTPEGRASPAP-------- 94
            ||..|......||.|.:::.|:::: ||:     .|.....::|:::|...:.|.||
Yeast    13 LATVAATGTAIGAYYYYNQLQQQQQ-RGKKNTINKDEKKDTKDSQKETEGAKKSTAPSNPPIYPV 76

Human    95 -GSGHPE-GPGAHLDMNSLDR-AQAAKNKGNKYFKAGKYEQAIQCYTEAISLCPTEKNVDLSTFY 156
             .:|.|: ...|:......|: |.|.|:|||::|:..||:.||:.|..|:.|  .|..|    ||
Yeast    77 SSNGEPDFSNKANFTAEEKDKYALALKDKGNQFFRNKKYDDAIKYYNWALEL--KEDPV----FY 135

Human   157 QNRAAAFEQLQKWKEVAQDCTKAVELNPKYVKALFRRAKAHEKLDNKKECLEDVTAVCILEGFQN 221
            .|.:|.:..:...|:|.:..|||:||.|.|.|.|.|||.|:|.|....:.:.|::.:.:...|.:
Yeast   136 SNLSACYVSVGDLKKVVEMSTKALELKPDYSKVLLRRASANEGLGKFADAMFDLSVLSLNGDFND 200

Human   222 QQSMLLADKVLKLLGKEKAKEKY---------------------KNREPLMPSPQFIKSYFSSFT 265
            .....:.::.|......|.|||:                     |:::..:||...:.|:|..|.
Yeast   201 ASIEPMLERNLNKQAMSKLKEKFGDIDTATATPTELSTQPAKERKDKQENLPSVTSMASFFGIFK 265

Human   266 DDI----------ISQPMLKG-----EKSDEDKDKEGEALEVKENSGYLKAKQYMEEE----NYD 311
            .::          ..:.::.|     ::|.|..||..|:        :.||.:..||:    |.|
Yeast   266 PELTFANYDESNEADKELMNGLSNLYKRSPESYDKADES--------FTKAARLFEEQLDKNNED 322

Human   312 KIISECSKEIDAEGKYMAEALLLRATFYLLIGNANAAKPDLDKVISLKEANVKLRANALIKRGSM 376
            :.:.|          .:|.:|.....|..|..:...|..|:.|.|.|..     |.|:.|....:
Yeast   323 EKLKE----------KLAISLEHTGIFKFLKNDPLGAHEDIKKAIELFP-----RVNSYIYMALI 372

Human   377 YMQQQQPLLSTQDFNMAADIDPQNADVYHHRGQLKILLDQVEEAVADFDECIRLRPESALAQAQK 441
            ...:.........|:.|..:|..|:.||:||||:..:|...::|..|||:...|.||:.....|.
Yeast   373 MADRNDSTEYYNYFDKALKLDSNNSSVYYHRGQMNFILQNYDQAGKDFDKAKELDPENIFPYIQL 437

Human   442 CFALYRQAYTGNNSSQIQAAMKGFEEVIKKFPRCAEGYALYAQALTDQQQFGKADEMYDKCIDLE 506
            ....||:    |.....:..   |.|..:|||...|....:|:.|||:..|.||.:.||..|:||
Yeast   438 ACLAYRE----NKFDDCETL---FSEAKRKFPEAPEVPNFFAEILTDKNDFDKALKQYDLAIELE 495

Human   507 PDNATTYVHKGLLQLQWK----------QDLDRGLELISKAIEIDNKCDFAYETMGTIEVQRGNM 561
              |....::.|:..|..|          ::......|:.||.::|.:.:.|...:..:::|:.::
Yeast   496 --NKLDGIYVGIAPLVGKATLLTRNPTVENFIEATNLLEKASKLDPRSEQAKIGLAQMKLQQEDI 558

Human   562 EKAIDMFNKAINLAKSEMEMAHLYSLCDAAHAQTEV------AKK 600
            ::||.:|.::.:||::..|.....:..:||..|..:      |||
Yeast   559 DEAITLFEESADLARTMEEKLQAITFAEAAKVQQRIRSDPVLAKK 603

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TOMM70	NP_055635.3	3a0801s09	41..601	CDD:273380	156/630 (25%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	67..107		11/54 (20%)
		TPR 1	114..147		14/32 (44%)
		TPR repeat	114..142	CDD:276809	13/27 (48%)
		TPR repeat	152..182	CDD:276809	9/29 (31%)
		TPR 2	153..186		12/32 (38%)
		TPR 3	294..327		7/36 (19%)
		TPR 4	329..362		9/32 (28%)
		TPR repeat	329..357	CDD:276809	7/27 (26%)
		TPR repeat	362..396	CDD:276809	5/33 (15%)
		TPR 5	367..400		5/32 (16%)
		TPR 6	401..434		13/32 (41%)
		TPR repeat	401..429	CDD:276809	11/27 (41%)
		TPR repeat	435..470	CDD:276809	6/34 (18%)
		TPR 7	440..475		9/34 (26%)
		TPR 8	476..509		13/32 (41%)
		TPR repeat	476..504	CDD:276809	10/27 (37%)
		TPR repeat	509..540	CDD:276809	7/40 (18%)
		TPR 9	511..544		7/42 (17%)
		TPR 10	545..578		7/32 (22%)
		TPR repeat	545..572	CDD:276809	5/26 (19%)
TOM70	NP_014278.3	3a0801s09	1..614	CDD:273380	156/630 (25%)
		TPR repeat	99..127	CDD:276809	13/27 (48%)
		TPR repeat	131..161	CDD:276809	10/33 (30%)
		TPR repeat	166..189	CDD:276809	8/22 (36%)
		TPR repeat	330..358	CDD:276809	7/27 (26%)
		TPR repeat	363..391	CDD:276809	4/27 (15%)
		TPR repeat	396..426	CDD:276809	12/29 (41%)
		TPR repeat	431..459	CDD:276809	6/34 (18%)
		TPR repeat	465..493	CDD:276809	10/27 (37%)
		TPR repeat	498..537	CDD:276809	6/38 (16%)
		TPR repeat	542..567	CDD:276809	5/24 (21%)