Protein Alignment TOMM70 and tomm70a

DIOPT Version :10

• Sequence 1: NP_055635.3
• Gene: TOMM70 / 9868
• HGNCID: 11985
• Length: 608
• Species: Homo sapiens
• Sequence 2: NP_956296.1
• Gene: tomm70a / 572969
• ZFINID: ZDB-GENE-030131-8173
• Length: 578
• Species: Danio rerio
• Alignment Length: 608
• Identity: 488/608 - (80%)
• Similarity: 530/608 - (87%)
• Gaps: 30/608 - (4%)

Human     1 MAASKPVEAAVVAAAVPSSGSGVGGGGTAGPGTGGLPRWQLALAVGAPLLLGAGAIYLWSRQQRR 65
            ||||||||        |.|||             |||||||||.||.|::||.||:|||:| .|.
Zfish     1 MAASKPVE--------PQSGS-------------GLPRWQLALLVGTPIVLGVGAVYLWNR-SRA 43

Human    66 REARGRGDASGLKRNSERKTPEGRASPAPGSGHPEGPGAHLDMNSLDRAQAAKNKGNKYFKAGKY 130
            :|.:|       |||.|||||||.|||..|......|... :::.|||||:||||||||||||||
Zfish    44 KEKQG-------KRNGERKTPEGSASPVQGQHGATNPELE-NLSPLDRAQSAKNKGNKYFKAGKY 100

Human   131 EQAIQCYTEAISLCPTEKNVDLSTFYQNRAAAFEQLQKWKEVAQDCTKAVELNPKYVKALFRRAK 195
            :.||:||||||.|||.||..||||||||||||:||..||.||.|||::||||||:||||||||||
Zfish   101 DHAIKCYTEAIGLCPKEKKGDLSTFYQNRAAAYEQQMKWTEVIQDCSQAVELNPRYVKALFRRAK 165

Human   196 AHEKLDNKKECLEDVTAVCILEGFQNQQSMLLADKVLKLLGKEKAKEKYKNREPLMPSPQFIKSY 260
            |.||||||||||||||||||||.|||||||||||||||.||||||||||||||||||||||||||
Zfish   166 ALEKLDNKKECLEDVTAVCILEVFQNQQSMLLADKVLKQLGKEKAKEKYKNREPLMPSPQFIKSY 230

Human   261 FSSFTDDIISQPMLKGEKSDEDKDKEGEALEVKENSGYLKAKQYMEEENYDKIISECSKEIDAEG 325
            ||||||||||||:.||||.||||||||||.|||.:||||||||||||||||||||||:|||::.|
Zfish   231 FSSFTDDIISQPLQKGEKKDEDKDKEGEASEVKGSSGYLKAKQYMEEENYDKIISECTKEIESGG 295

Human   326 KYMAEALLLRATFYLLIGNANAAKPDLDKVISLKEANVKLRANALIKRGSMYMQQQQPLLSTQDF 390
            :|.|||||||||||||||||.||:||||:||::.:|:|||||||||||||||||||||.||||||
Zfish   296 RYSAEALLLRATFYLLIGNATAAQPDLDRVINMNDASVKLRANALIKRGSMYMQQQQPQLSTQDF 360

Human   391 NMAADIDPQNADVYHHRGQLKILLDQVEEAVADFDECIRLRPESALAQAQKCFALYRQAYTGNNS 455
            ||||:||.:||||||||||||||||||||||.||||||:|||:|||||||||||||||||||||.
Zfish   361 NMAAEIDHRNADVYHHRGQLKILLDQVEEAVGDFDECIKLRPDSALAQAQKCFALYRQAYTGNNP 425

Human   456 SQIQAAMKGFEEVIKKFPRCAEGYALYAQALTDQQQFGKADEMYDKCIDLEPDNATTYVHKGLLQ 520
            ||:|.||.|||:||::||:|||||||||||||||||||||||||||||:||||||||||||||||
Zfish   426 SQVQKAMDGFEDVIRRFPKCAEGYALYAQALTDQQQFGKADEMYDKCIELEPDNATTYVHKGLLQ 490

Human   521 LQWKQDLDRGLELISKAIEIDNKCDFAYETMGTIEVQRGNMEKAIDMFNKAINLAKSEMEMAHLY 585
            |||||||:.|||||||||||||||||||||||||||||||::|||||||||||||||||||||||
Zfish   491 LQWKQDLEMGLELISKAIEIDNKCDFAYETMGTIEVQRGNLDKAIDMFNKAINLAKSEMEMAHLY 555

Human   586 SLCDAAHAQTEVAKKYGLKPPTL 608
            ||||||:||||||||||||||||
Zfish   556 SLCDAAYAQTEVAKKYGLKPPTL 578

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TOMM70	NP_055635.3	3a0801s09	41..601	CDD:273380	461/559 (82%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	67..107		17/39 (44%)
		TPR 1	114..147		27/32 (84%)
		TPR repeat	114..142	CDD:276809	23/27 (85%)
		TPR repeat	152..182	CDD:276809	22/29 (76%)
		TPR 2	153..186		25/32 (78%)
		TPR 3	294..327		26/32 (81%)
		TPR 4	329..362		25/32 (78%)
		TPR repeat	329..357	CDD:276809	24/27 (89%)
		TPR repeat	362..396	CDD:276809	31/33 (94%)
		TPR 5	367..400		29/32 (91%)
		TPR 6	401..434		30/32 (94%)
		TPR repeat	401..429	CDD:276809	26/27 (96%)
		TPR repeat	435..470	CDD:276809	29/34 (85%)
		TPR 7	440..475		27/34 (79%)
		TPR 8	476..509		31/32 (97%)
		TPR repeat	476..504	CDD:276809	27/27 (100%)
		TPR repeat	509..540	CDD:276809	28/30 (93%)
		TPR 9	511..544		30/32 (94%)
		TPR 10	545..578		30/32 (94%)
		TPR repeat	545..572	CDD:276809	24/26 (92%)
tomm70a	NP_956296.1	3a0801s09	40..571	CDD:273380	448/539 (83%)
		TPR repeat	84..112	CDD:276809	23/27 (85%)
		TPR repeat	122..152	CDD:276809	22/29 (76%)
		TPR repeat	299..327	CDD:276809	24/27 (89%)
		TPR repeat	336..366	CDD:276809	28/29 (97%)
		TPR repeat	371..399	CDD:276809	26/27 (96%)
		TPR repeat	446..474	CDD:276809	27/27 (100%)
		TPR repeat	479..510	CDD:276809	28/30 (93%)
		TPR repeat	515..542	CDD:276809	24/26 (92%)