Protein Alignment TOMM70 and Tomm70

DIOPT Version :10

• Sequence 1: NP_055635.3
• Gene: TOMM70 / 9868
• HGNCID: 11985
• Length: 608
• Species: Homo sapiens
• Sequence 2: NP_997684.1
• Gene: Tomm70 / 304017
• RGDID: 1303049
• Length: 610
• Species: Rattus norvegicus
• Alignment Length: 611
• Identity: 566/611 - (92%)
• Similarity: 588/611 - (96%)
• Gaps: 4/611 - (0%)

Human     1 MAASKPVEAAVVAAAVPSSGSGVG-GGGTAGPGTGG--LPRWQLALAVGAPLLLGAGAIYLWSRQ 62
            ||||||||||:.|||.|:||:||| .||||.||:|.  ||||.:|||:||||||||||:|||||:
  Rat     1 MAASKPVEAAMAAAAAPASGNGVGSSGGTAAPGSGAGTLPRWHVALAIGAPLLLGAGAMYLWSRR 65

Human    63 QRRREARGRGDASGLKRNSERKTPEGRASPAPGSGHPEGPGAHLDMNSLDRAQAAKNKGNKYFKA 127
            :|||||.||||||||||||||||||||||||.||| |:|.|..|:|:||||||||||||||||||
  Rat    66 RRRREAGGRGDASGLKRNSERKTPEGRASPALGSG-PDGSGDSLEMSSLDRAQAAKNKGNKYFKA 129

Human   128 GKYEQAIQCYTEAISLCPTEKNVDLSTFYQNRAAAFEQLQKWKEVAQDCTKAVELNPKYVKALFR 192
            ||||||||||||||||||||||.||||||||||||||||||||||||||||||||||||||||||
  Rat   130 GKYEQAIQCYTEAISLCPTEKNADLSTFYQNRAAAFEQLQKWKEVAQDCTKAVELNPKYVKALFR 194

Human   193 RAKAHEKLDNKKECLEDVTAVCILEGFQNQQSMLLADKVLKLLGKEKAKEKYKNREPLMPSPQFI 257
            |||||||||||||||||||||||||||||:||||||||||||||||.||||||||||||||||||
  Rat   195 RAKAHEKLDNKKECLEDVTAVCILEGFQNEQSMLLADKVLKLLGKENAKEKYKNREPLMPSPQFI 259

Human   258 KSYFSSFTDDIISQPMLKGEKSDEDKDKEGEALEVKENSGYLKAKQYMEEENYDKIISECSKEID 322
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
  Rat   260 KSYFSSFTDDIISQPMLKGEKSDEDKDKEGEALEVKENSGYLKAKQYMEEENYDKIISECSKEID 324

Human   323 AEGKYMAEALLLRATFYLLIGNANAAKPDLDKVISLKEANVKLRANALIKRGSMYMQQQQPLLST 387
            |:|||||||||||||||||||:||||||||||||||||||||||||||||||:|.||||||:|||
  Rat   325 AQGKYMAEALLLRATFYLLIGSANAAKPDLDKVISLKEANVKLRANALIKRGTMCMQQQQPMLST 389

Human   388 QDFNMAADIDPQNADVYHHRGQLKILLDQVEEAVADFDECIRLRPESALAQAQKCFALYRQAYTG 452
            |||||||:|||.|:||||||||||||||.|||||||||.||||||:.|||||||||||||||||.
  Rat   390 QDFNMAAEIDPMNSDVYHHRGQLKILLDLVEEAVADFDACIRLRPKFALAQAQKCFALYRQAYTA 454

Human   453 NNSSQIQAAMKGFEEVIKKFPRCAEGYALYAQALTDQQQFGKADEMYDKCIDLEPDNATTYVHKG 517
            |||||:|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
  Rat   455 NNSSQVQAAMKGFEEVIKKFPRCAEGYALYAQALTDQQQFGKADEMYDKCIDLEPDNATTYVHKG 519

Human   518 LLQLQWKQDLDRGLELISKAIEIDNKCDFAYETMGTIEVQRGNMEKAIDMFNKAINLAKSEMEMA 582
            |||||||||||:|||||||||||||||||||||||||||||||||||||||||||||||||||||
  Rat   520 LLQLQWKQDLDKGLELISKAIEIDNKCDFAYETMGTIEVQRGNMEKAIDMFNKAINLAKSEMEMA 584

Human   583 HLYSLCDAAHAQTEVAKKYGLKPPTL 608
            ||||||||||||||||||||||||||
  Rat   585 HLYSLCDAAHAQTEVAKKYGLKPPTL 610

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TOMM70	NP_055635.3	3a0801s09	41..601	CDD:273380	527/559 (94%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	67..107		32/39 (82%)
		TPR 1	114..147		32/32 (100%)
		TPR repeat	114..142	CDD:276809	27/27 (100%)
		TPR repeat	152..182	CDD:276809	29/29 (100%)
		TPR 2	153..186		32/32 (100%)
		TPR 3	294..327		31/32 (97%)
		TPR 4	329..362		31/32 (97%)
		TPR repeat	329..357	CDD:276809	26/27 (96%)
		TPR repeat	362..396	CDD:276809	30/33 (91%)
		TPR 5	367..400		28/32 (88%)
		TPR 6	401..434		29/32 (91%)
		TPR repeat	401..429	CDD:276809	24/27 (89%)
		TPR repeat	435..470	CDD:276809	32/34 (94%)
		TPR 7	440..475		32/34 (94%)
		TPR 8	476..509		32/32 (100%)
		TPR repeat	476..504	CDD:276809	27/27 (100%)
		TPR repeat	509..540	CDD:276809	29/30 (97%)
		TPR 9	511..544		31/32 (97%)
		TPR 10	545..578		32/32 (100%)
		TPR repeat	545..572	CDD:276809	26/26 (100%)
Tomm70	NP_997684.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	69..109		33/40 (83%)
		3a0801s09	<116..603	CDD:273380	468/486 (96%)
		TPR 1	116..149		32/32 (100%)
		TPR repeat	116..144	CDD:276809	27/27 (100%)
		TPR repeat	149..184	CDD:276809	33/34 (97%)
		TPR 2	155..188		32/32 (100%)
		TPR 3	296..329		31/32 (97%)
		TPR 4	331..364		31/32 (97%)
		TPR repeat	331..359	CDD:276809	26/27 (96%)
		TPR repeat	364..398	CDD:276809	30/33 (91%)
		TPR 5	369..402		28/32 (88%)
		TPR 6	403..436		29/32 (91%)
		TPR repeat	403..431	CDD:276809	24/27 (89%)
		TPR 7	444..477		30/32 (94%)
		TPR repeat	446..472	CDD:276809	23/25 (92%)
		TPR 8	478..511		32/32 (100%)
		TPR repeat	478..506	CDD:276809	27/27 (100%)
		TPR repeat	511..542	CDD:276809	29/30 (97%)
		TPR 9	513..546		31/32 (97%)
		TPR 10	547..580		32/32 (100%)
		TPR repeat	547..574	CDD:276809	26/26 (100%)