Protein Alignment TOMM70 and Tomm70a

DIOPT Version :10

• Sequence 1: NP_055635.3
• Gene: TOMM70 / 9868
• HGNCID: 11985
• Length: 608
• Species: Homo sapiens
• Sequence 2: NP_613065.2
• Gene: Tomm70a / 28185
• MGIID: 106295
• Length: 611
• Species: Mus musculus
• Alignment Length: 611
• Identity: 567/611 - (92%)
• Similarity: 590/611 - (96%)
• Gaps: 3/611 - (0%)

Human     1 MAASKPVEAAVVAAAVPSSGSGV-GGGGTAGPGTGG--LPRWQLALAVGAPLLLGAGAIYLWSRQ 62
            ||||||:|||:.|||.|.||:|| |||||||||:|.  ||||.:|||:||||||||||:|||||:
Mouse     1 MAASKPIEAAMAAAAAPGSGNGVGGGGGTAGPGSGAGTLPRWHVALAIGAPLLLGAGAMYLWSRR 65

Human    63 QRRREARGRGDASGLKRNSERKTPEGRASPAPGSGHPEGPGAHLDMNSLDRAQAAKNKGNKYFKA 127
            :|||||.||||||||||||||||||||||||.||||.:|.|..|:|:||||||||||||||||||
Mouse    66 RRRREAGGRGDASGLKRNSERKTPEGRASPALGSGHHDGSGDSLEMSSLDRAQAAKNKGNKYFKA 130

Human   128 GKYEQAIQCYTEAISLCPTEKNVDLSTFYQNRAAAFEQLQKWKEVAQDCTKAVELNPKYVKALFR 192
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse   131 GKYEQAIQCYTEAISLCPTEKNVDLSTFYQNRAAAFEQLQKWKEVAQDCTKAVELNPKYVKALFR 195

Human   193 RAKAHEKLDNKKECLEDVTAVCILEGFQNQQSMLLADKVLKLLGKEKAKEKYKNREPLMPSPQFI 257
            |||||||||||||||||||||||||||||:||||||||||||||||.||||||||||||||||||
Mouse   196 RAKAHEKLDNKKECLEDVTAVCILEGFQNEQSMLLADKVLKLLGKENAKEKYKNREPLMPSPQFI 260

Human   258 KSYFSSFTDDIISQPMLKGEKSDEDKDKEGEALEVKENSGYLKAKQYMEEENYDKIISECSKEID 322
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse   261 KSYFSSFTDDIISQPMLKGEKSDEDKDKEGEALEVKENSGYLKAKQYMEEENYDKIISECSKEID 325

Human   323 AEGKYMAEALLLRATFYLLIGNANAAKPDLDKVISLKEANVKLRANALIKRGSMYMQQQQPLLST 387
            |:|||||||||||||||||||:||||||||||||||||||||||||||||||:|.||||||:|||
Mouse   326 AQGKYMAEALLLRATFYLLIGSANAAKPDLDKVISLKEANVKLRANALIKRGTMCMQQQQPMLST 390

Human   388 QDFNMAADIDPQNADVYHHRGQLKILLDQVEEAVADFDECIRLRPESALAQAQKCFALYRQAYTG 452
            |||||||:|||.|:||||||||||||||.|||||||||.||||||:.|||||||||||||||||.
Mouse   391 QDFNMAAEIDPMNSDVYHHRGQLKILLDLVEEAVADFDACIRLRPKFALAQAQKCFALYRQAYTA 455

Human   453 NNSSQIQAAMKGFEEVIKKFPRCAEGYALYAQALTDQQQFGKADEMYDKCIDLEPDNATTYVHKG 517
            |||||:|||||||||:|||||||||||||||||||||||||||||||||||||||||||||||||
Mouse   456 NNSSQVQAAMKGFEEIIKKFPRCAEGYALYAQALTDQQQFGKADEMYDKCIDLEPDNATTYVHKG 520

Human   518 LLQLQWKQDLDRGLELISKAIEIDNKCDFAYETMGTIEVQRGNMEKAIDMFNKAINLAKSEMEMA 582
            |||||||||||:|||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse   521 LLQLQWKQDLDKGLELISKAIEIDNKCDFAYETMGTIEVQRGNMEKAIDMFNKAINLAKSEMEMA 585

Human   583 HLYSLCDAAHAQTEVAKKYGLKPPTL 608
            ||||||||||||||||||||||||||
Mouse   586 HLYSLCDAAHAQTEVAKKYGLKPPTL 611

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TOMM70	NP_055635.3	3a0801s09	41..601	CDD:273380	527/559 (94%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	67..107		32/39 (82%)
		TPR 1	114..147		32/32 (100%)
		TPR repeat	114..142	CDD:276809	27/27 (100%)
		TPR repeat	152..182	CDD:276809	29/29 (100%)
		TPR 2	153..186		32/32 (100%)
		TPR 3	294..327		31/32 (97%)
		TPR 4	329..362		31/32 (97%)
		TPR repeat	329..357	CDD:276809	26/27 (96%)
		TPR repeat	362..396	CDD:276809	30/33 (91%)
		TPR 5	367..400		28/32 (88%)
		TPR 6	401..434		29/32 (91%)
		TPR repeat	401..429	CDD:276809	24/27 (89%)
		TPR repeat	435..470	CDD:276809	31/34 (91%)
		TPR 7	440..475		31/34 (91%)
		TPR 8	476..509		32/32 (100%)
		TPR repeat	476..504	CDD:276809	27/27 (100%)
		TPR repeat	509..540	CDD:276809	29/30 (97%)
		TPR 9	511..544		31/32 (97%)
		TPR 10	545..578		32/32 (100%)
		TPR repeat	545..572	CDD:276809	26/26 (100%)
Tomm70a	NP_613065.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	69..110		33/40 (83%)
		3a0801s09	<117..604	CDD:273380	468/486 (96%)
		TPR 1	117..150		32/32 (100%)
		TPR repeat	117..145	CDD:276809	27/27 (100%)
		TPR repeat	155..185	CDD:276809	29/29 (100%)
		TPR 2	156..189		32/32 (100%)
		TPR 3	297..330		31/32 (97%)
		TPR 4	332..365		31/32 (97%)
		TPR repeat	332..360	CDD:276809	26/27 (96%)
		TPR repeat	365..399	CDD:276809	30/33 (91%)
		TPR 5	370..403		28/32 (88%)
		TPR 6	404..437		29/32 (91%)
		TPR repeat	404..432	CDD:276809	24/27 (89%)
		TPR 7	445..478		29/32 (91%)
		TPR repeat	447..473	CDD:276809	22/25 (88%)
		TPR 8	479..512		32/32 (100%)
		TPR repeat	479..507	CDD:276809	27/27 (100%)
		TPR repeat	512..543	CDD:276809	29/30 (97%)
		TPR 9	514..547		31/32 (97%)
		TPR 10	548..581		32/32 (100%)
		TPR repeat	548..575	CDD:276809	26/26 (100%)