Protein Alignment TOMM70 and tom70

DIOPT Version :10

• Sequence 1: NP_055635.3
• Gene: TOMM70 / 9868
• HGNCID: 11985
• Length: 608
• Species: Homo sapiens
• Sequence 2: NP_593767.1
• Gene: tom70 / 2543304
• PomBaseID: SPAC6B12.12
• Length: 625
• Species: Schizosaccharomyces pombe
• Alignment Length: 555
• Identity: 150/555 - (27%)
• Similarity: 266/555 - (47%)
• Gaps: 69/555 - (12%)

Human    61 RQQRRREARGRGDASGLKRNSERKTPEGRASPAPGSGHPEGPGAHLDMNSLDRAQAA---KNKGN 122
            :.:::.:|:..||:|..|..:|....                    .|...:||:.|   |..||
pombe   115 KNKKKVKAKKVGDSSVDKIATEESVK--------------------SMTKEERAKLAAELKTLGN 159

Human   123 KYFKAGKYEQAIQCYTEAISLCPTEKNVDLSTFYQNRAAAFEQLQKWKEVAQDCTKAVELNPKYV 187
            |.:...:|..||..||:||: |..:     ..|:.||||.:..:..:::|.:|.::|:.|:..||
pombe   160 KAYGQKEYANAIDYYTQAIT-CSHD-----PIFFSNRAACYAAIGDFEQVIKDTSEALSLDSSYV 218

Human   188 KALFRRAKAHEKLDNKKECLEDVTAVCILEGFQNQQSMLLADKVLKLLGKEKAKEKYKNREPLMP 252
            |||.||:.|:|:|....|.|.|.|..||.:||.|:......:::||.:.::|:....|.|.|.:|
pombe   219 KALNRRSAAYEQLGKLDEALMDSTVSCIFDGFANESMTATVERLLKKVAEKKSSALLKERPPKLP 283

Human   253 SPQFIKSYFSSFTDDIISQPMLKGEKSDEDKDKEGEALEVKENSGYLKAKQYMEEENYDKIISEC 317
            :..||::|..||.    :||     |...|...:|:| .:.|...||:..:|  :.:|||....|
pombe   284 AASFIQTYLDSFH----AQP-----KPLFDNKFDGDA-ALAEAYEYLEKGEY--QLSYDKAKESC 336

Human   318 SKEIDAEGKYMAEALLLR-----ATFYLLIGNANAAKPDLDKVISLKEANVKLRANALIKRGSMY 377
            .      |.:.:.::..|     .||..:.|::..:..:.:..|.|....::    ..|:..:.|
pombe   337 L------GSFSSPSVNARTHNLVGTFKFVSGDSKGSMENFNAAIKLDRKFIQ----PYIRLSAAY 391

Human   378 MQQQQPLLSTQDFNMAADIDPQNADVYHHRGQLKILLDQVEEAVADFDECIRLRPESALAQAQKC 442
            :.:.......:..|.|..:|..::|:|:||.|::.:..:..||::|:.:.|.|......:..|..
pombe   392 LDENDNEKMWKVLNDAESVDKTDSDLYYHRAQVRFVSGEFAEAISDYQKSIALDDSFIYSHIQLG 456

Human   443 FALYRQAYTGNNSSQIQAAMKGFEEVIKKFPRCAEGYALYAQALTDQQQFGKADEMYDKCIDLEP 507
            .|.|:       :..|..:||.||:..|:||..:|.|..:.:.|.|||:|..|.:.:|..|:||.
pombe   457 VAQYK-------THAIAESMKTFEDCKKRFPNSSEVYNYFGEILLDQQKFDDAVKNFDHAIELEK 514

Human   508 D------NATTYVHKGLLQLQWKQDLDRGLELISKAIEIDNKCDFAYETMGTIEVQRGNMEKAID 566
            .      :|...::|.|...|||:|:.:...|..:|:..|.:||.|..:|....:|:|...:|::
pombe   515 REHLTIMSAMPLINKALAVFQWKKDISQAENLCRQALSADPECDIAIASMAQFLLQQGKAREALE 579

Human   567 MFNKAINLAKSEMEMAHLYSLCDAAHAQTEVAKKY 601
            .|.|:..||::|.||.:.:|..:|...|..:.:||
pombe   580 YFEKSAQLARTESEMVNAFSYAEATRTQIALTEKY 614

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TOMM70	NP_055635.3	3a0801s09	41..601	CDD:273380	148/553 (27%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	67..107		6/39 (15%)
		TPR 1	114..147		14/35 (40%)
		TPR repeat	114..142	CDD:276809	12/30 (40%)
		TPR repeat	152..182	CDD:276809	8/29 (28%)
		TPR 2	153..186		9/32 (28%)
		TPR 3	294..327		9/32 (28%)
		TPR 4	329..362		6/37 (16%)
		TPR repeat	329..357	CDD:276809	4/32 (13%)
		TPR repeat	362..396	CDD:276809	4/33 (12%)
		TPR 5	367..400		5/32 (16%)
		TPR 6	401..434		10/32 (31%)
		TPR repeat	401..429	CDD:276809	8/27 (30%)
		TPR repeat	435..470	CDD:276809	8/34 (24%)
		TPR 7	440..475		11/34 (32%)
		TPR 8	476..509		12/38 (32%)
		TPR repeat	476..504	CDD:276809	9/27 (33%)
		TPR repeat	509..540	CDD:276809	9/30 (30%)
		TPR 9	511..544		9/32 (28%)
		TPR 10	545..578		10/32 (31%)
		TPR repeat	545..572	CDD:276809	8/26 (31%)
tom70	NP_593767.1	3a0801s09	15..622	CDD:273380	150/555 (27%)
		TPR repeat	151..179	CDD:276809	11/27 (41%)
		TPR repeat	183..213	CDD:276809	8/34 (24%)
		TPR repeat	310..341	CDD:276809	10/39 (26%)
		TPR repeat	347..375	CDD:276809	4/27 (15%)
		TPR repeat	384..409	CDD:276809	4/24 (17%)
		TPR repeat	415..443	CDD:276809	8/27 (30%)
		TPR repeat	448..478	CDD:276809	8/36 (22%)
		TPR repeat	483..511	CDD:276809	9/27 (33%)
		TPR repeat	516..553	CDD:276809	9/36 (25%)
		TPR repeat	558..586	CDD:276809	8/27 (30%)