Protein Alignment TOMM70 and tomm70

DIOPT Version :10

• Sequence 1: NP_055635.3
• Gene: TOMM70 / 9868
• HGNCID: 11985
• Length: 608
• Species: Homo sapiens
• Sequence 2: NP_001096527.1
• Gene: tomm70 / 100125169
• XenbaseID: XB-GENE-1007952
• Length: 577
• Species: Xenopus tropicalis
• Alignment Length: 612
• Identity: 490/612 - (80%)
• Similarity: 536/612 - (87%)
• Gaps: 39/612 - (6%)

Human     1 MAASKPVEAAVVAAAVPSSGSGVGGGGTAGPGTGGLPRWQLALAVGAPLLLGAGAIYLWSRQQRR 65
            ||||||||        |..|.|:             |.|:||||:|||||:||||:|||    ||
 Frog     1 MAASKPVE--------PQGGPGI-------------PHWKLALAIGAPLLVGAGAVYLW----RR 40

Human    66 REARGRGDASGLKRNSERKTPEGRASPAPGSG----HPEGPGAHLDMNSLDRAQAAKNKGNKYFK 126
            .:|.        ||:.:|:||||||||.|..|    :|:  .|..:::.|::|||||||||||||
 Frog    41 HKAE--------KRDKQRRTPEGRASPVPAEGSSTNNPQ--DAPQELSPLEKAQAAKNKGNKYFK 95

Human   127 AGKYEQAIQCYTEAISLCPTEKNVDLSTFYQNRAAAFEQLQKWKEVAQDCTKAVELNPKYVKALF 191
            |.|||||||||||||||||.:...||||||||||||.||||.||||.|||||||||||:||||||
 Frog    96 ASKYEQAIQCYTEAISLCPVDTKSDLSTFYQNRAAAHEQLQNWKEVVQDCTKAVELNPRYVKALF 160

Human   192 RRAKAHEKLDNKKECLEDVTAVCILEGFQNQQSMLLADKVLKLLGKEKAKEKYKNREPLMPSPQF 256
            |||||||:||||||||||||||||||||||||||.|||||||||||||||:||||||||||||||
 Frog   161 RRAKAHERLDNKKECLEDVTAVCILEGFQNQQSMFLADKVLKLLGKEKAKDKYKNREPLMPSPQF 225

Human   257 IKSYFSSFTDDIISQPMLKGEKSDEDKDKEGEALEVKENSGYLKAKQYMEEENYDKIISECSKEI 321
            ||||||||||||||||:.|||||||||||||||..|||.|||||||:||||||||||||||:||:
 Frog   226 IKSYFSSFTDDIISQPLQKGEKSDEDKDKEGEAAVVKEKSGYLKAKKYMEEENYDKIISECTKEV 290

Human   322 DAEGKYMAEALLLRATFYLLIGNANAAKPDLDKVISLKEANVKLRANALIKRGSMYMQQQQPLLS 386
            ::.|||:|||||||||||||||||.|||||||:|||::|.||||||||||||||||||||.|.||
 Frog   291 ESVGKYVAEALLLRATFYLLIGNAAAAKPDLDQVISMEECNVKLRANALIKRGSMYMQQQLPALS 355

Human   387 TQDFNMAADIDPQNADVYHHRGQLKILLDQVEEAVADFDECIRLRPESALAQAQKCFALYRQAYT 451
            ||||||||||||||||||||||||||||||||:||.||||||||||:||||||||||||||:|||
 Frog   356 TQDFNMAADIDPQNADVYHHRGQLKILLDQVEDAVEDFDECIRLRPDSALAQAQKCFALYRKAYT 420

Human   452 GNNSSQIQAAMKGFEEVIKKFPRCAEGYALYAQALTDQQQFGKADEMYDKCIDLEPDNATTYVHK 516
            |:|..||:.||:|||:||.|||:||||||||||||||||||||||||||||||||||||||||||
 Frog   421 GSNPLQIKEAMQGFEDVITKFPKCAEGYALYAQALTDQQQFGKADEMYDKCIDLEPDNATTYVHK 485

Human   517 GLLQLQWKQDLDRGLELISKAIEIDNKCDFAYETMGTIEVQRGNMEKAIDMFNKAINLAKSEMEM 581
            |||||||||||::||:||||||||||||||||||||||||||||::|||:|||||||||||||||
 Frog   486 GLLQLQWKQDLEKGLDLISKAIEIDNKCDFAYETMGTIEVQRGNLDKAIEMFNKAINLAKSEMEM 550

Human   582 AHLYSLCDAAHAQTEVAKKYGLKPPTL 608
            ||||||||||:||||||:|||||||||
 Frog   551 AHLYSLCDAAYAQTEVARKYGLKPPTL 577

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TOMM70	NP_055635.3	3a0801s09	41..601	CDD:273380	468/563 (83%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	67..107		16/43 (37%)
		TPR 1	114..147		31/32 (97%)
		TPR repeat	114..142	CDD:276809	26/27 (96%)
		TPR repeat	152..182	CDD:276809	26/29 (90%)
		TPR 2	153..186		29/32 (91%)
		TPR 3	294..327		25/32 (78%)
		TPR 4	329..362		28/32 (88%)
		TPR repeat	329..357	CDD:276809	25/27 (93%)
		TPR repeat	362..396	CDD:276809	31/33 (94%)
		TPR 5	367..400		30/32 (94%)
		TPR 6	401..434		30/32 (94%)
		TPR repeat	401..429	CDD:276809	25/27 (93%)
		TPR repeat	435..470	CDD:276809	26/34 (76%)
		TPR 7	440..475		25/34 (74%)
		TPR 8	476..509		32/32 (100%)
		TPR repeat	476..504	CDD:276809	27/27 (100%)
		TPR repeat	509..540	CDD:276809	27/30 (90%)
		TPR 9	511..544		29/32 (91%)
		TPR 10	545..578		29/32 (91%)
		TPR repeat	545..572	CDD:276809	23/26 (88%)
tomm70	NP_001096527.1	3a0801s09	20..570	CDD:273380	468/563 (83%)
		TPR repeat	83..111	CDD:276809	26/27 (96%)
		TPR repeat	116..151	CDD:276809	27/34 (79%)
		TPR repeat	298..326	CDD:276809	25/27 (93%)
		TPR repeat	331..365	CDD:276809	31/33 (94%)
		TPR repeat	370..398	CDD:276809	25/27 (93%)
		TPR repeat	404..438	CDD:276809	25/33 (76%)
		TPR repeat	445..473	CDD:276809	27/27 (100%)
		TPR repeat	478..509	CDD:276809	27/30 (90%)
		TPR repeat	514..541	CDD:276809	23/26 (88%)