DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment TRIL and Fili

DIOPT Version :9

Sequence 1:NP_055632.2 Gene:TRIL / 9865 HGNCID:22200 Length:811 Species:Homo sapiens
Sequence 2:NP_001369108.1 Gene:Fili / 5740472 FlyBaseID:FBgn0085397 Length:789 Species:Drosophila melanogaster


Alignment Length:808 Identity:197/808 - (24%)
Similarity:291/808 - (36%) Gaps:214/808 - (26%)


- Green bases have known domain annotations that are detailed below.


Human     9 LLLVVCGCLALPPLAEPVCPERCDC---QHPQHLLCTNRGLRVVPKTSSLPSPHDVLTYSLGGNF 70
            |||::...:.|||.....||.:|.|   :.....||.:..|..||...:..:.:..||       
  Fly    24 LLLLLLTLVILPPETTAFCPSKCQCLGGEANSRALCVDAALEDVPIQLNPETKYINLT------- 81

Human    71 ITNITAFDFHR--LGQLRRLDLQYNQIRSLHPKTFEKLSRLEELYLGNNLLQALAPGTLAPLRKL 133
            :..|...:|..  ..:|..|||..|.|.:|..|.||..|.|..|.|..||               
  Fly    82 VNRIRTLEFSLPFYMKLEILDLSQNIIETLGSKNFEYQSELRTLNLSRNL--------------- 131

Human   134 RILYANGNEISRLSRGSFEGLESLVKLRLDGNALGALPDAVFAPLGNLLYLHLESNRIRFLGKNA 198
                     :|.|.:.:|:||.:|:.|.|..|.:..:.....:.|.:|:.|.|.:|.|..|..|.
  Fly   132 ---------VSSLHKHAFKGLTNLLLLDLSFNRIETVHPTALSDLASLVELDLTNNNIVSLEDNC 187

Human   199 FAQLGKLRFLNLSANEL----QPSLRHAATFAPLRSLSSLILSANNLQHLGPRIFQHLPRLGLLS 259
            |..:..|..|....|.|    ..:|.|      |.:|.||.:|.|.::.:....|:.|..|..||
  Fly   188 FKGMNTLEVLVFRNNRLLDVPASNLWH------LHALKSLDMSLNLVEFVRNDSFEGLKELLALS 246

Human   260 LRGNQLTHLAPEAFWGLEALRELRLEGNRLSQLPTALLEPLHSLEALDLSGNELSALHPATFGHL 324
            ::||.::.|...||.||.:|:.|.|..|.|:.:||..|..|.:|..|:|.||..|.|....|.:|
  Fly   247 VQGNVMSELDLSAFEGLISLKHLDLSDNNLTMVPTQQLSKLSNLTYLNLGGNRFSQLPAVAFLNL 311

Human   325 GRLRELSL-RNNALSALSGDIFAASPALYRLDLDGNGWTCDCRLRGLKRWMGDWHSQG--RLLTV 386
            ..||||.| |.:.|..:....|..:..|..|.|:.|....|..:|..         ||  .:|.|
  Fly   312 FHLRELHLSRLDFLQRIDSRAFVDNTHLQTLHLNNNPQLSDIPMRLF---------QGNPNILEV 367

Human   387 FVQCRHPPALRGKY-----LD-----YLDDQQLQ--------------NGSCADPSPSASLTADR 427
            ::|..   :|:..|     :|     ||.|..||              |....||.         
  Fly   368 YMQSN---SLQTLYSAQFPVDQLQKLYLGDNPLQCNCSLLWLWRLVTGNFEGVDPG--------- 420

Human   428 RRQPLPTAAGEEMTPPAGLAEELPPQPQLQQQGRFLAGVAWDGAARELVGNRSALRLSRRGPGLQ 492
                :..|||..:   |.||:|...: :|..:...:|... ||.|                    
  Fly   421 ----MEHAAGGAV---AALAKEADDE-ELADEATAVASTD-DGVA-------------------- 456

Human   493 QPSPSVAAAAGPAPQSL--DLHKKPQRGRPTRADPALAEPTPTASPGSA-------PSPAGDPWQ 548
                  |.||..|.|.:  .||         ..:|:..|...::|..::       .....|.|:
  Fly   457 ------ALAAYIAEQHIVNALH---------TTEPSAYELATSSSNRNSGILRMDRQQIGCDIWR 506

Human   549 RATKHRLGTEHQERAAQSDGGAGLPP-LVSDPCDFNKFILCNLTVEAVGADSASVRWAVREHRSP 612
            ...:.|     ::....|:|....|. :|:..|   ..|.| |.|..:|   .||.:.:|..:..
  Fly   507 DKVRTR-----RKLLTMSEGEITCPAHIVTVVC---AVITC-LLVAMIG---ISVLYYLRFVKRR 559

Human   613 RPLGGARFRLLFDRFGQQPKFHRFVYLPESSDSATLRELRGDTPYLVCVEGVLG-GRVCPVAPRD 676
            |       :||.:| |........:.:.:       |.|:|..|      |.|| |....:...:
  Fly   560 R-------KLLHER-GPMRTSKSIINVHD-------RILQGHNP------GGLGLGMSMTLGGGN 603

Human   677 HCAGL----------------------VTLPEAGSRGGVDYQLLTLALLTVNALLVLLALAAWAS 719
            |..||                      :.|...|..|..:||..||..|....|...||....|:
  Fly   604 HVNGLGMTLNYPHHAQTLQAHHHYHQAMPLQSHGGNGNHEYQQTTLPQLDKLELERYLAAQTIAN 668

Human   720 RWLRRKLRARRKGGAPV-----HVRHMY 742
            .:     ||.:....||     ...|:|
  Fly   669 EY-----RALKPWELPVKEADDEPEHLY 691

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
TRILNP_055632.2 LRR_RI <2..194 CDD:238064 50/189 (26%)
leucine-rich repeat 37..61 CDD:275380 5/23 (22%)
LRR 1 61..81 4/19 (21%)
leucine-rich repeat 62..84 CDD:275380 4/23 (17%)
LRR_8 84..143 CDD:290566 16/58 (28%)
LRR 2 84..105 9/20 (45%)
leucine-rich repeat 85..108 CDD:275380 10/22 (45%)
LRR 3 108..129 5/20 (25%)
leucine-rich repeat 109..132 CDD:275380 5/22 (23%)
LRR 4 132..153 3/20 (15%)
leucine-rich repeat 133..156 CDD:275380 5/22 (23%)
LRR_8 156..215 CDD:290566 16/58 (28%)
LRR 5 156..177 4/20 (20%)
leucine-rich repeat 157..180 CDD:275380 5/22 (23%)
LRR 6 180..201 8/20 (40%)
leucine-rich repeat 181..204 CDD:275380 8/22 (36%)
LRR 7 204..223 6/22 (27%)
leucine-rich repeat 205..254 CDD:275380 14/52 (27%)
LRR 8 230..251 6/20 (30%)
LRR_8 239..289 CDD:290566 17/49 (35%)
LRR_RI <249..>364 CDD:238064 42/115 (37%)
LRR 9 254..275 8/20 (40%)
leucine-rich repeat 255..278 CDD:275380 10/22 (45%)
LRR 10 278..299 8/20 (40%)
LRR_8 279..337 CDD:290566 24/58 (41%)
leucine-rich repeat 279..302 CDD:275380 9/22 (41%)
LRR 11 302..323 8/20 (40%)
leucine-rich repeat 303..326 CDD:275380 9/22 (41%)
LRR 12 326..347 8/21 (38%)
leucine-rich repeat 327..346 CDD:275380 7/19 (37%)
leucine-rich repeat 351..363 CDD:275378 4/11 (36%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 484..549 12/73 (16%)
fn3 589..667 CDD:278470 18/78 (23%)
FiliNP_001369108.1 leucine-rich repeat 75..97 CDD:275378 4/28 (14%)
leucine-rich repeat 98..121 CDD:275380 10/22 (45%)
LRR_8 120..180 CDD:404697 20/83 (24%)
leucine-rich repeat 122..145 CDD:275380 10/46 (22%)
leucine-rich repeat 146..169 CDD:275380 5/22 (23%)
LRR <161..>354 CDD:227223 64/198 (32%)
leucine-rich repeat 170..193 CDD:275380 8/22 (36%)
leucine-rich repeat 194..217 CDD:275380 7/28 (25%)
leucine-rich repeat 218..265 CDD:275380 17/46 (37%)
leucine-rich repeat 266..289 CDD:275380 9/22 (41%)
leucine-rich repeat 290..313 CDD:275380 9/22 (41%)
leucine-rich repeat 314..338 CDD:275380 8/23 (35%)
LRR_8 337..397 CDD:404697 17/71 (24%)
leucine-rich repeat 339..360 CDD:275380 6/29 (21%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR24373
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
22.010

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