DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment TRIL and haf

DIOPT Version :9

Sequence 1:NP_055632.2 Gene:TRIL / 9865 HGNCID:22200 Length:811 Species:Homo sapiens
Sequence 2:NP_001356954.1 Gene:haf / 33339 FlyBaseID:FBgn0261509 Length:1347 Species:Drosophila melanogaster


Alignment Length:898 Identity:215/898 - (23%)
Similarity:331/898 - (36%) Gaps:204/898 - (22%)


- Green bases have known domain annotations that are detailed below.


Human    18 ALPPLAEP---VCPERCDCQHPQHLLCTNRGLRVVP--KTSSLPSPHDVLTYSLGGNFITNITAF 77
            |||....|   :.|......|..|..|..:  |.||  :||.      :..|:||..........
  Fly     9 ALPAATTPLLLLLPLILGRLHVAHAQCPWQ--RDVPDLQTSC------ICAYNLGRELSVQCDQV 65

Human    78 DFHRLGQLRRLDLQYNQIRSLHPKTFEKLSRLEELYLGNNLLQALAPGTLAPLRKLRILYANGNE 142
            ||.:|            :.:::  |..:|..::.||:.|:.:..|.....:.| .|..|..:...
  Fly    66 DFSQL------------LAAMN--THARLKPVDLLYVNNSTISELPDAVFSNL-SLHNLQLSSCG 115

Human   143 ISRLSRGSFEGLESLVK-LRLDGNALGALPDAVFAPLGNLLYLHLESNRIRFLGKNAFAQLGKLR 206
            |.|::.|:|:|.||::: |.|..|.|..:|......||.|..|.|..|::..:..:||..|.||.
  Fly   116 IQRIATGAFKGQESVLRNLNLQDNLLADVPVEALKVLGKLNLLDLSKNQLSHIPDDAFVGLTKLS 180

Human   207 FLNLSANE----------LQPSLRH-----------AATFAPLRSLSSLILSANNLQHL----GP 246
            .|.|:.|.          |:.||::           ..:...|:||:.|.||.|.::.|    |.
  Fly   181 TLKLNDNNVTLASNAFRGLEQSLKNLNLKGTKQRKVPESIRGLKSLAFLDLSQNGIKELPGAGGI 245

Human   247 RIFQHLPRLGLLSLRGNQLTHLAPEAFWGL-EALRELRLEGNRLSQLPTALLEPLHSLEALDLSG 310
            |:|..|..|..|:|..|.:..:...||.|: :.|..|.|..|.|::.|...:..|..|..||:..
  Fly   246 RVFDGLDALTALNLERNLIQSIGETAFAGVRKTLSSLSLLNNLLAEFPIGAVHSLKELRVLDIGF 310

Human   311 NELSALHPATF-GHLGRLRELSLRNNALSALSGDIFAASPALYR-LDLDGNGWTCDCRLRGLKRW 373
            |.|::|..|.| |:.| :..|:|..|.||::....||...|..| |.|.|....|||:|    ||
  Fly   311 NLLTSLPEAAFRGNPG-ITLLALDGNPLSSVPEGAFAHLNATLRGLSLGGRFLHCDCKL----RW 370

Human   374 MGDWHSQGRLLTVFVQ-----CRHPPALRGKYLDYLDDQQLQNGSCADPSPSASLTADRRRQPLP 433
            :.:|...|.|.....:     |..||..|.:....:..::|   ||.|.:.:|            
  Fly   371 VAEWIRNGDLQVTSRERNPQFCGTPPRFRDRGFYSIQPEEL---SCPDIADAA------------ 420

Human   434 TAAGEEMTPPAGLAEE----LPPQPQLQQQGRFLAGVAWD-GAARELVGNRSALRLSRRGPGLQQ 493
                  :..|.|||:.    ||..|.         .|.:: |.....||..:|    ...|....
  Fly   421 ------LRGPVGLADNLKPTLPSSPD---------SVEYETGTGTGTVGTGTA----ASAPVTSS 466

Human   494 PSPSVAAAAGPAPQSLDLHKKPQRGRPTRADPALAEPT---PTASPGSAPSPAGDPWQRATKHRL 555
            .|.|.:... |...:.....:|...|.|...|..:..|   .||||.|.|...|....:||....
  Fly   467 VSSSTSTTT-PTTTTTTTTAEPTTRRSTTRPPTKSTTTISATTASPASNPPVNGTGTVQATSITT 530

Human   556 GTEHQERAAQSD------------------------GGAG------LPPLVSDPCDFNKFILCNL 590
            .:.....::.|.                        ||||      .||||              
  Fly   531 SSSSSSSSSTSTGHGNGKQAPGWRQGVTNGNGNSGVGGAGGLHKPQRPPLV-------------- 581

Human   591 TVEAVG-----------ADSASVRWAVREHRS---------PRPLGGARFRLLFDRFGQQPKFHR 635
                :|           |:...|:.|.|:..|         ...||   ||:::..||:: .|.:
  Fly   582 ----LGYPPQRGTRIDDANEVQVKHAFRQDSSVIIQWDSDTANILG---FRVVYRLFGEK-AFKQ 638

Human   636 FVYLPESSDSATLRELRGDTPYLVCVEGVLGGRVCP-VAPRDHCAGLVTLPEAGSRGGVDYQLLT 699
            ...|..|.....::.:......:|||..:....|.| ..|...|..:.|:  |.....:|...:.
  Fly   639 GPPLESSEREFKIKNVPAQECIIVCVISLEELHVTPETVPYQQCREVRTV--ASQASNMDKITIA 701

Human   700 LALLTVNALLVLLALAAWASRWLRRKLRARRK-----GGAPVHVRHMYSTRRPLRSMGTGVSADF 759
            .:......::|.:.:...|||..|:...:::|     ||.||:......:..||.|:.|     .
  Fly   702 ASAAICGTIIVAVIVFIAASRRSRKLQSSQQKSPLPIGGLPVNCCGPTGSPGPLGSIAT-----L 761

Human   760 SGFQSHRPRTTVCALSEADL-------IEFPCDRFMDSAGGGAGGSLRREDRL 805
            |.|.:|:....|.|.|...:       :|.|.|  |.|...|..|.:.:...|
  Fly   762 SAFNNHKEWDQVSAYSGRSIPRPRIYPVEQPDD--MRSHFSGMPGKVGKSRSL 812

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
TRILNP_055632.2 LRR_RI <2..194 CDD:238064 46/181 (25%)
leucine-rich repeat 37..61 CDD:275380 7/25 (28%)
LRR 1 61..81 5/19 (26%)
leucine-rich repeat 62..84 CDD:275380 6/21 (29%)
LRR_8 84..143 CDD:290566 9/58 (16%)
LRR 2 84..105 1/20 (5%)
leucine-rich repeat 85..108 CDD:275380 2/22 (9%)
LRR 3 108..129 4/20 (20%)
leucine-rich repeat 109..132 CDD:275380 5/22 (23%)
LRR 4 132..153 6/20 (30%)
leucine-rich repeat 133..156 CDD:275380 7/22 (32%)
LRR_8 156..215 CDD:290566 20/69 (29%)
LRR 5 156..177 6/21 (29%)
leucine-rich repeat 157..180 CDD:275380 6/23 (26%)
LRR 6 180..201 6/20 (30%)
leucine-rich repeat 181..204 CDD:275380 7/22 (32%)
LRR 7 204..223 8/39 (21%)
leucine-rich repeat 205..254 CDD:275380 19/73 (26%)
LRR 8 230..251 10/24 (42%)
LRR_8 239..289 CDD:290566 17/54 (31%)
LRR_RI <249..>364 CDD:238064 38/117 (32%)
LRR 9 254..275 6/20 (30%)
leucine-rich repeat 255..278 CDD:275380 7/23 (30%)
LRR 10 278..299 6/20 (30%)
LRR_8 279..337 CDD:290566 20/58 (34%)
leucine-rich repeat 279..302 CDD:275380 7/22 (32%)
LRR 11 302..323 8/21 (38%)
leucine-rich repeat 303..326 CDD:275380 9/23 (39%)
LRR 12 326..347 6/20 (30%)
leucine-rich repeat 327..346 CDD:275380 5/18 (28%)
leucine-rich repeat 351..363 CDD:275378 4/12 (33%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 484..549 16/67 (24%)
fn3 589..667 CDD:278470 18/97 (19%)
hafNP_001356954.1 LRR <52..>252 CDD:227223 55/214 (26%)
leucine-rich repeat 86..105 CDD:275380 5/19 (26%)
leucine-rich repeat 106..129 CDD:275380 7/22 (32%)
LRR_8 131..189 CDD:338972 19/57 (33%)
leucine-rich repeat 131..154 CDD:275380 6/22 (27%)
leucine-rich repeat 155..178 CDD:275380 7/22 (32%)
leucine-rich repeat 179..202 CDD:275380 5/22 (23%)
leucine-rich repeat 203..225 CDD:275380 2/21 (10%)
leucine-rich repeat 226..253 CDD:275380 10/26 (38%)
LRR_8 254..337 CDD:338972 27/83 (33%)
leucine-rich repeat 254..302 CDD:275380 14/47 (30%)
leucine-rich repeat 303..326 CDD:275380 9/22 (41%)
leucine-rich repeat 327..350 CDD:275380 7/22 (32%)
PCC 332..>413 CDD:188093 25/87 (29%)
PRK10927 <1061..>1097 CDD:236797
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 93 1.000 Inparanoid score I5085
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.960

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