DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment LRIG2 and CYR1

DIOPT Version :9

Sequence 1:	NP_055628.1	Gene:	LRIG2 / 9860	HGNCID:	20889	Length:	1065	Species:	Homo sapiens
Sequence 2:	NP_012529.3	Gene:	CYR1 / 853452	SGDID:	S000003542	Length:	2026	Species:	Saccharomyces cerevisiae

Alignment Length:	1060	Identity:	213/1060 - (20%)
Similarity:	384/1060 - (36%)	Gaps:	306/1060 - (28%)

- Green bases have known domain annotations that are detailed below.

Human    81 DFSHNRLSNWNISL----------ESQTLQEVKMNYNELTEIPYFGEPTSNITLLSLVHNIIPEI 135
            :|.|..|.|.:::.          |.::| :|..|.|....:.:.   .|:|.||||     ..:
Yeast   793 EFVHVDLRNMDLTTPPIIFYQHTSEIESL-DVSNNANIFLPLEFI---ESSIKLLSL-----RMV 848

Human   136 NAQALQFYPA-------LESLDLSSNIISEIKTSSFPRMQLKYLNLSNNRITTLEAGCFD----- 188
            |.:|.:| |:       |.||:|..|.|.::..|......|..|||..|.:.:|.||..:
Yeast   849 NIRASKF-PSNITKAYKLVSLELQRNFIRKVPNSIMKLSNLTILNLQCNELESLPAGFVELKNLQ 912

Human   189 ----------------NLSSSLLVVKLNRNRMSMIPPKIFKLPHLQFLELKRNRIKIVEGLTFQG 237
                            |..::||.:.|:.|::..:|.....|..|..:.|..|::..:..|:  .
Yeast   913 LLDLSSNKFMHYPEVINYCTNLLQIDLSYNKIQSLPQSTKYLVKLAKMNLSHNKLNFIGDLS--E 975

Human   238 LDSLRSLKMQRNGISKLKDGAFFGLNNMEELELEHNNLTRVNKGWLYGLRMLQQLYVSQNAIERI 302
            :..||:|.::.|.||.:|..|    :|::.|.|..|.::....    .|..|:.|.:.:|.|..|
Yeast   976 MTDLRTLNLRYNRISSIKTNA----SNLQNLFLTDNRISNFED----TLPKLRALEIQENPITSI 1032

Human   303 SPDAWEFCQRLSELDLSYNQLTRLDESAFVGLSLLERLNLGDNRVTHIADGVFRFLSNLQTLDLR 367
            |...: :.:.::.|.|:..||:.:.......||.||:|.|..|.:|.:...:.: |:.|..|.:.
Yeast  1033 SFKDF-YPKNMTSLTLNKAQLSSIPGELLTKLSFLEKLELNQNNLTRLPQEISK-LTKLVFLSVA 1095

Human   368 NNEISWAIEDASEAFAGLTSLTKLILQGNQIKSITKKAFIGLESLEHLDLNNNAIMSIQENAFSQ 432
            .|::.:...:.|:    |.||..|.|..|.|:....    |:|:||...||      |..|||..
Yeast  1096 RNKLEYIPPELSQ----LKSLRTLDLHSNNIRDFVD----GMENLELTSLN------ISSNAFGN 1146

Human   433 THLKELILNTSSLLCDCHLKWLLQWLVDNNFQHSVNVSCAHPEW-----LAGQSILNVDLKDFVC 492
            :.|:....:..|.........:.....||.|..::        |     .....:||:...:|..
Yeast  1147 SSLENSFYHNMSYGSKLSKSLMFFIAADNQFDDAM--------WPLFNCFVNLKVLNLSYNNFSD 1203

Human   493 DDFLKPQIRTH------------PETII-------ALRGMNVTLTCTAVSSSDSPMSTVWRKDSE 538
            ...:|.:..|.            .:|::       .:...|..|:..|..|:.|.:|......::
Yeast  1204 VSHMKLESITELYLSGNKLTTLSGDTVLKWSSLKTLMLNSNQMLSLPAELSNLSQLSVFDVGANQ 1268

Human   539 ILYDVDTENFVRYWQQAGEALEYTSILHLFNVNFTDEGKYQ--CIVTNHFGSNYSQKAKLTVNEM 601
            :.|::...::...|:...| |:|        :||:...:::  ..:::...::.|.   |||  :
Yeast  1269 LKYNISNYHYDWNWRNNKE-LKY--------LNFSGNRRFEIKSFISHDIDADLSD---LTV--L 1319

Human   602 PSFLKT--PMDLTIRTGAMA------RLECAAEGHPAPQISWQKDGGTDFPAARERRMHVMPEDD 658
            |. ||.  .||:|:.|..:.      ||...|.     .|:..:.|..|....|:   :|...|.
Yeast  1320 PQ-LKVLGLMDVTLNTTKVPDENVNFRLRTTAS-----IINGMRYGVADTLGQRD---YVSSRDV 1375

Human   659 VF--FIANVKIED---MGIYSCMAQNTAGGLSANASLTVLETPSFIRPLE---DKTVTRGETA-- 713
            .|  |..|   :|   :.::....||...|.:.:..:..:.....||.||   |:|....:||
Yeast  1376 TFERFRGN---DDECLLCLHDSKNQNADYGHNISRIVRDIYDKILIRQLERYGDETDDNIKTALR 1437

Human   714 ------------VLQCIAGGSPAPRLNWTKDDGPLL---------VTERHFFAA-ANQLLIIVDA 756
                        :|..:..|:....|::    ..||         :..:..||| ....:.|:.
Yeast  1438 FSFLQLNKEINGMLNSVDNGADVANLSY----ADLLSGACSTVIYIRGKKLFAANLGDCMAILS- 1497

Human   757 GLEDAGKYTCIMSNTLGTERGHI--------YLN----------------------VISSPNCDS 791
              ::.|.|..:....|.|:|...        |:|                      :.:||  |.
Yeast  1498 --KNNGDYQTLTKQHLPTKREEYERIRISGGYVNNGKLDGVVDVSRAVGFFDLLPHIHASP--DI 1558

Human   792 SQSSIGHEDDGWTTVGIVIIVVVCCVVGTSLIW----VIVIYHMRRKNEDYSITNTEELNLPADI 852
            |..::...|:             ..:|.|..:|    |..:..:.|:|      :|:.|...|::
Yeast  1559 SVVTLTKADE-------------MLIVATHKLWEYMDVDTVCDIAREN------STDPLRAAAEL 1604

Human   853 PSYLSSQGTLSEPQEGYSNSEAGSHQQLMPPANGYIHKGTDGGTGTRVICSDCYDNANIYSRTRE 917
            ..:..:.|.                              |:..|   ::|...|:|
Yeast  1605 KDHAMAYGC------------------------------TENIT---ILCLALYEN--------- 1627

Human   918 YCPYTYIAEEDVLDQTLSSLMVQMP--KETYL------VHPP-----------QDTTALESLIPS 963
                  |.:::......:|||.:..  ::|.|      :.||           :.:|.|..|.|:
Yeast  1628 ------IQQQNRFTLNKNSLMTRRSTFEDTTLRRLQPEISPPTGNLAMVFTDIKSSTFLWELFPN 1686

Human   964 ANREPSAFPTNHERISEKKL 983
            |.|  :|..| |..|..::|
Yeast  1687 AMR--TAIKT-HNDIMRRQL 1703

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
LRIG2	NP_055628.1	LRR_RI	<46..205	CDD:238064	39/161 (24%)
		LRR 1	76..97		5/25 (20%)
		LRR 2	98..119		4/20 (20%)
		leucine-rich repeat	99..121	CDD:275380	4/21 (19%)
		LRR_8	120..179	CDD:290566	22/65 (34%)
		LRR 3	121..142		7/20 (35%)
		leucine-rich repeat	122..145	CDD:275378	8/22 (36%)
		LRR 4	145..166		7/27 (26%)
		leucine-rich repeat	146..168	CDD:275380	7/21 (33%)
		LRR_8	168..251	CDD:290566	23/103 (22%)
		LRR 5	168..189		8/41 (20%)
		leucine-rich repeat	169..192	CDD:275380	9/43 (21%)
		LRR 6	193..214		5/20 (25%)
		leucine-rich repeat	194..216	CDD:275380	6/21 (29%)
		LRR 7	216..237		4/20 (20%)
		leucine-rich repeat	217..240	CDD:275380	4/22 (18%)
		LRR_8	240..299	CDD:290566	16/58 (28%)
		LRR 8	240..261		8/20 (40%)
		leucine-rich repeat	241..264	CDD:275380	8/22 (36%)
		LRR 9	264..285		4/20 (20%)
		leucine-rich repeat	265..288	CDD:275380	4/22 (18%)
		LRR_RI	266..492	CDD:238064	53/230 (23%)
		LRR 10	288..309		6/20 (30%)
		leucine-rich repeat	289..312	CDD:275380	6/22 (27%)
		LRR_8	312..371	CDD:290566	16/58 (28%)
		LRR 11	312..333		4/20 (20%)
		leucine-rich repeat	313..336	CDD:275380	5/22 (23%)
		LRR 12	336..357		6/20 (30%)
		leucine-rich repeat	337..360	CDD:275380	7/22 (32%)
		LRR_8	359..422	CDD:290566	17/62 (27%)
		LRR 13	360..382		4/21 (19%)
		leucine-rich repeat	361..385	CDD:275380	4/23 (17%)
		LRR 14	387..408		6/20 (30%)
		leucine-rich repeat	388..411	CDD:275380	6/22 (27%)
		LRR 15	411..432		8/20 (40%)
		leucine-rich repeat	412..434	CDD:275380	8/21 (38%)
		LRRCT	445..493	CDD:214507	7/52 (13%)
		Ig	502..598	CDD:299845	17/116 (15%)
		IG	504..598	CDD:214652	16/102 (16%)
		I-set	602..692	CDD:254352	23/102 (23%)
		Ig_1	619..693	CDD:143240	16/84 (19%)
		I-set	696..783	CDD:254352	24/143 (17%)
		Ig	714..783	CDD:299845	16/108 (15%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	962..990		8/22 (36%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1003..1040
CYR1	NP_012529.3	Ad_cyc_g-alpha	368..418	CDD:369912
		RA_PHLPP_like	678..776	CDD:340473
		PLN00113	792..>1273	CDD:215061	117/523 (22%)
		leucine-rich repeat	796..817	CDD:275380	3/20 (15%)
		leucine-rich repeat	818..839	CDD:275380	4/24 (17%)
		leucine-rich repeat	840..864	CDD:275380	9/29 (31%)
		leucine-rich repeat	865..887	CDD:275380	7/21 (33%)
		leucine-rich repeat	888..910	CDD:275380	8/21 (38%)
		leucine-rich repeat	911..933	CDD:275380	1/21 (5%)
		leucine-rich repeat	934..956	CDD:275380	6/21 (29%)
		leucine-rich repeat	957..978	CDD:275380	4/22 (18%)
		leucine-rich repeat	979..1018	CDD:275380	13/46 (28%)
		leucine-rich repeat	1019..1041	CDD:275380	6/22 (27%)
		leucine-rich repeat	1042..1065	CDD:275380	5/22 (23%)
		leucine-rich repeat	1066..1088	CDD:275380	7/22 (32%)
		leucine-rich repeat	1089..1111	CDD:275380	5/25 (20%)
		leucine-rich repeat	1167..1187	CDD:275380	4/27 (15%)
		leucine-rich repeat	1191..1211	CDD:275380	4/19 (21%)
		leucine-rich repeat	1236..1258	CDD:275380	4/21 (19%)
		leucine-rich repeat	1259..1287	CDD:275380	3/27 (11%)
		PP2C	1374..1617	CDD:395385	48/303 (16%)
		CYCc	1613..1825	CDD:214485	24/142 (17%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910