DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment LRIG2 and sma-10

DIOPT Version :9

Sequence 1:	NP_055628.1	Gene:	LRIG2 / 9860	HGNCID:	20889	Length:	1065	Species:	Homo sapiens
Sequence 2:	NP_499896.1	Gene:	sma-10 / 176849	WormBaseID:	WBGene00020649	Length:	881	Species:	Caenorhabditis elegans

Alignment Length:	855	Identity:	239/855 - (27%)
Similarity:	402/855 - (47%)	Gaps:	92/855 - (10%)

- Green bases have known domain annotations that are detailed below.

Human    42 LCPAPCSCRIPLLDCSRRKLPAPSWRALSGLLPPDTAILDFSHNRLSN------------WNISL 94
            :|...|.|...::|||...|     ..:...:|.:|.||..|.|.:.:            ..:.:
Worm    24 VCIGLCHCVGNVVDCSSLDL-----SEIPTTIPNNTRILLLSDNEIESIDKSRLKGFYFLQTLDI 83

Human    95 ESQTLQEVKMNY--------------NELTEIPYFGEPTSNITLLSLVHNIIPEINAQALQFYPA 145
            .:..::.:...:              |.|..||.......::..|.|..|:|..:.::.|.:..|
Worm    84 SNNIIRHIDFEFFYNLPNLKILNIRKNRLARIPRGSHELGHLEKLDLRSNLISTVTSEELSYLAA 148

Human   146 LESLDLSSNIISEI-KTSSFPRMQLKYLNLSNNRITTLEAGCFDNLSSSLLVVKLNRNRMSMIPP 209
            :.|:|||.|:||.: |.::..::.::.|:|::|.||.:....|.:. ::|:.:||.||.::.:..
Worm   149 VRSVDLSRNLISYLPKPTTSAKVNIEKLDLASNSITDIGTDHFSSF-NTLVTLKLARNHITTLNQ 212

Human   210 KIF-KLPHLQFLELKRNRIKIVEGLTFQGLDSLRSLKMQRNGISKLKDGAFFGLNNMEELELEHN 273
            ..| :|..|:.|:|.||.|:.|..|.|..|.||:::.:.||.:.:|.||.|:....::.|.|..|
Worm   213 FSFSRLRKLESLDLTRNMIREVRFLAFNQLPSLQNVSLARNDVYRLDDGMFYACEGLKHLNLSTN 277

Human   274 NLTRVNKGWLYGLRMLQQLYVSQNAIERISPDAWEFCQRLSELDLSYNQLTRLDESAFVGLSLLE 338
            .:..|.:||::||..|:.|.:|.|.|:.....:|....:|..|.|..|::..|...:|..|..||
Worm   278 RVQAVTEGWMFGLTSLEVLDLSYNQIQSFHISSWSHTPKLKWLSLHSNRIQSLPSGSFRVLRQLE 342

Human   339 RLNLGDNRVTHIADGVFRF----LSNLQTLDLRNNEISWAIEDASEAF-AGLTSLTKLILQGNQI 398
            .|.|..|.:    |.:.:|    :|:|..|||.:|.::..:||.:..: ..:..|..|....||:
Worm   343 ELILSANSI----DSLHKFALVGMSSLHKLDLSSNTLAVCVEDGAVLYNTSMPFLRSLRFTNNQL 403

Human   399 KSITKKAFIGLESLEHLDLNNNAIMSIQENAFSQTHLKELILNTSSLLCDCHLKWLLQWL----V 459
            :.|.|:||....:||.|||.:|.|.:|...||....||.|::|:||:||||.:.||..|:    :
Worm   404 RVIPKRAFERFPALEELDLTDNPIATIHPEAFEPLELKRLVMNSSSILCDCQISWLASWIYRLKL 468

Human   460 DNNFQHSVNVSCAHPEWLAGQSILNVDLKDFVC-DDFLKPQIRTHPETIIALRGMNVTLTCTAVS 523
            |.:   |:...|::|..||...::.:|..:..| :|..:.:|...|..:..|.|.....||....
Worm   469 DKS---SIIAKCSYPPPLADLYVVAIDTANLTCHNDSPRAKIVRQPVEVSTLIGEKARFTCNVYG 530

Human   524 SSDSPMSTVWR-----------KDSEILYDVDTENFVR--YWQQAGEALEYTSILHLFNVNFTDE 575
            :  ||:|..||           :||.....::....|.  :.::...|.|    |.|.||..||.
Worm   531 A--SPLSIEWRVMENGQPRVLVQDSATFLSINRTAVVNGTFDERELAAAE----LLLDNVAMTDN 589

Human   576 GKYQCIVTNHFGSNYSQKAKLTVNEMPSFLKTPMDLTIRTGAMARLECAAEGHPAPQISWQKDGG 640
            .:|||:..|.|||::|...||.|.:.|.|..||.|:.:..|..|:..|||.|.|.|:|.|..: .
Worm   590 SEYQCVARNRFGSDFSTHVKLQVYQAPKFTYTPEDMPLLVGQTAKFLCAATGTPRPEIKWAFE-Q 653

Human   641 TDFPAARERRMHVMPEDDVFFIANVKIEDMGIYSCMAQNTAGGLSANASLTVLETPSFIRP---- 701
            ..||||..||::|.|.||..:|.||..||.|.|:|.|.|.||...|:|:|.|.|. .|..|
Worm   654 IPFPAAEARRLYVTPNDDHIYIMNVTKEDQGAYTCHATNVAGQTQASANLIVFEN-FFHYPESPD 717

Human   702 LEDKTVTRGETAVLQCIAG-GSPAPRLNWTKDDGPLLVTERHFFAAANQLLIIVDAGLEDAGKYT 765
            |....:.:.:...:.|... .|...|:.|.:....:|..::..|:..:|:|.:......|:|:|:
Worm   718 LSPMLIKKRDALKIDCSCDLISSRQRMVWKRQQQVILFLKKAKFSDNDQILTLTQTTFSDSGEYS 782

Human   766 CIM--SNTLGTERGHIYLNVISSPNCDSSQSSIGHE------------DDGWTTVGIVIIVVVCC 816
            |.:  .:|: ..|....:.|::.....||::::...            |:..:|...:.::..|.
Worm   783 CELWVDDTI-LMRKITMVKVVNEDEFVSSEATLTQRVQRIRAMASKLVDNIKSTGNGIYLMASCS 846

Human   817 VVGTSLIWVI 826
            ..|..::.||
Worm   847 AFGLMILGVI 856

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
LRIG2	NP_055628.1	LRR_RI	<46..205	CDD:238064	41/185 (22%)
		LRR 1	76..97		5/32 (16%)
		LRR 2	98..119		4/34 (12%)
		leucine-rich repeat	99..121	CDD:275380	4/35 (11%)
		LRR_8	120..179	CDD:290566	17/59 (29%)
		LRR 3	121..142		5/20 (25%)
		leucine-rich repeat	122..145	CDD:275378	5/22 (23%)
		LRR 4	145..166		9/21 (43%)
		leucine-rich repeat	146..168	CDD:275380	8/22 (36%)
		LRR_8	168..251	CDD:290566	27/83 (33%)
		LRR 5	168..189		6/20 (30%)
		leucine-rich repeat	169..192	CDD:275380	6/22 (27%)
		LRR 6	193..214		6/21 (29%)
		leucine-rich repeat	194..216	CDD:275380	7/22 (32%)
		LRR 7	216..237		9/20 (45%)
		leucine-rich repeat	217..240	CDD:275380	10/22 (45%)
		LRR_8	240..299	CDD:290566	20/58 (34%)
		LRR 8	240..261		8/20 (40%)
		leucine-rich repeat	241..264	CDD:275380	7/22 (32%)
		LRR 9	264..285		6/20 (30%)
		leucine-rich repeat	265..288	CDD:275380	8/22 (36%)
		LRR_RI	266..492	CDD:238064	74/234 (32%)
		LRR 10	288..309		6/20 (30%)
		leucine-rich repeat	289..312	CDD:275380	6/22 (27%)
		LRR_8	312..371	CDD:290566	20/62 (32%)
		LRR 11	312..333		6/20 (30%)
		leucine-rich repeat	313..336	CDD:275380	7/22 (32%)
		LRR 12	336..357		6/20 (30%)
		leucine-rich repeat	337..360	CDD:275380	7/26 (27%)
		LRR_8	359..422	CDD:290566	22/63 (35%)
		LRR 13	360..382		7/21 (33%)
		leucine-rich repeat	361..385	CDD:275380	7/24 (29%)
		LRR 14	387..408		8/20 (40%)
		leucine-rich repeat	388..411	CDD:275380	8/22 (36%)
		LRR 15	411..432		10/20 (50%)
		leucine-rich repeat	412..434	CDD:275380	10/21 (48%)
		LRRCT	445..493	CDD:214507	15/52 (29%)
		Ig	502..598	CDD:299845	31/108 (29%)
		IG	504..598	CDD:214652	31/106 (29%)
		I-set	602..692	CDD:254352	40/89 (45%)
		Ig_1	619..693	CDD:143240	34/73 (47%)
		I-set	696..783	CDD:254352	17/93 (18%)
		Ig	714..783	CDD:299845	14/71 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	962..990
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1003..1040
sma-10	NP_499896.1	LRRNT	29..54	CDD:214470	7/29 (24%)
		leucine-rich repeat	55..77	CDD:275380	4/21 (19%)
		LRR_8	78..135	CDD:290566	7/56 (13%)
		LRR_4	78..116	CDD:289563	2/37 (5%)
		leucine-rich repeat	78..101	CDD:275380	0/22 (0%)
		LRR_RI	100..303	CDD:238064	61/203 (30%)
		leucine-rich repeat	102..124	CDD:275380	4/21 (19%)
		leucine-rich repeat	125..148	CDD:275380	5/22 (23%)
		leucine-rich repeat	149..172	CDD:275380	8/22 (36%)
		LRR_8	172..231	CDD:290566	18/59 (31%)
		leucine-rich repeat	173..196	CDD:275380	6/23 (26%)
		leucine-rich repeat	197..220	CDD:275380	7/22 (32%)
		leucine-rich repeat	221..244	CDD:275380	10/22 (45%)
		LRR_8	243..303	CDD:290566	20/59 (34%)
		leucine-rich repeat	245..268	CDD:275380	7/22 (32%)
		LRR_RI	269..453	CDD:238064	61/187 (33%)
		leucine-rich repeat	269..292	CDD:275380	8/22 (36%)
		leucine-rich repeat	293..316	CDD:275380	6/22 (27%)
		LRR_8	315..373	CDD:290566	19/61 (31%)
		leucine-rich repeat	317..340	CDD:275380	7/22 (32%)
		leucine-rich repeat	341..364	CDD:275380	7/26 (27%)
		leucine-rich repeat	365..392	CDD:275380	7/26 (27%)
		LRR_8	393..450	CDD:290566	23/56 (41%)
		leucine-rich repeat	393..416	CDD:275380	8/22 (36%)
		leucine-rich repeat	417..438	CDD:275380	10/20 (50%)
		I-set	506..612	CDD:254352	32/111 (29%)
		Ig	522..606	CDD:143165	25/89 (28%)
		I-set	616..705	CDD:254352	40/89 (45%)
		Ig	633..705	CDD:299845	34/72 (47%)
		Ig	716..786	CDD:299845	13/69 (19%)
		IG	719..788	CDD:214652	12/68 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C161448721
Domainoid	1	1.000	80	1.000	Domainoid score	I6033
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	351	1.000	Inparanoid score	I1491
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG49439
OrthoDB	1	1.010	-	-		D161719at2759
OrthoFinder	1	1.000	-	-		FOG0001817
OrthoInspector	1	1.000	-	-		otm15651
orthoMCL	1	0.900	-	-		OOG6_104558
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1179
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	11	10.810