Protein Alignment CEP350 and CLIP-190

DIOPT Version :10

• Sequence 1: XP_047291332.1
• Gene: CEP350 / 9857
• HGNCID: 24238
• Length: 3189
• Species: Homo sapiens
• Sequence 2: NP_001368962.1
• Gene: CLIP-190 / 35042
• FlyBaseID: FBgn0020503
• Length: 1795
• Species: Drosophila melanogaster
• Alignment Length: 2157
• Identity: 417/2157 - (19%)
• Similarity: 789/2157 - (36%)
• Gaps: 627/2157 - (29%)

Human  1087 GTSTSRPLNATATPLSGVSYED------DFVSSPGT-GTSTEKKSTLEPHSTLS----------P 1134
            |||...|...||.|..|.:...      ..:.:|.| ||...:.|.::..|:..          |
  Fly    10 GTSAPFPSPVTADPEPGATASKLPGPIRSNIPTPATSGTGIPQPSKMKAPSSFGSTGSVSKIGRP 74

Human  1135 QEDHSNRKSAYDPSSVDVTSQHSSGAQSAASSRSSTSSKGKKGKKEKTE--------WLD----- 1186
            ..:|:..||.  |...:.||.......:.:|..|:.:..........||        ||.
  Fly    75 CCNHTTPKSG--PPPREATSMSRESDDNLSSINSAYTDNSSAVLTANTEQFIIGQRVWLGGTRPG 137

Human  1187 --SFTGNVQ-------NSLLDEEKAER-GSHQGK-------KSGTSSKLSVKDFEQTLDTDSTLE 1234
              :|.|:..       ..:|||...:. |...||       |.|..|:|          |..|..
  Fly   138 QIAFIGDTHFAAGEWAGVVLDEPNGKNDGCVSGKRYFQCEPKRGIFSRL----------TRLTTY 192

Human  1235 DLSGHSVSVSSDKGRSQKTPTSPLSPSSQKSLQFDVAGTSSERSKSSVMPPTI------------ 1287
            .|:|            .:||||||:.||....: .|:.|:|.|| |.:..|.|
  Fly   193 PLAG------------AQTPTSPLAKSSPDRSR-TVSPTASIRS-SMLRSPGIGGKNGMAVGDRV 243

Human  1288 ---TGF------------------------------KPNAPLTDLNPAASRTTTENMAPI----- 1314
               :||                              |.:..:.|:.....:.......||
  Fly   244 IVSSGFGSRPGILRYLGETQFAPGNWCGVELDEPSGKNDGTVDDIRYFECKPKYGVFVPIAKVSL 308

Human  1315 -PGSK--RFSPAGLHHRMAAELSYLNAI--------EESVRQLSDVERVRGISLAQQESVSLAQI 1368
             |.||  |.|..|....:.: :..:|:|        ..:.:|......|:.|....:...|:..:
  Fly   309 SPSSKKTRLSRTGSRESLTS-IGTMNSIATTATSRMRMNAQQRKSSTPVKPILATPKSQFSMQDL 372

Human  1369 IKAQQQRHERDLALLKLKAEQEALESQRQLEETRNKAAQVHAESLQQVVQSQREVTEVL------ 1427
            ::.:||..|      ||..|::.     ..|:.:|:|.|:           |:.:.||:
  Fly   373 LREKQQHVE------KLMVERDL-----DREDAQNQALQL-----------QKNINEVIIFTDTM 415

Human  1428 ----------------QEATCKIAAQQ------SETARLTTDAARQICEMAELTRTHISDAVVAS 1470
                            :::..|:..||      :.::.:||..:         ||..|:.|..|:
  Fly   416 YAPLPYADRSRPYRPSKKSRVKVPQQQHIWVPTTLSSSITTSTS---------TRPTIAAATAAA 471

Human  1471 GAPLAI----LYDHQRQHLPDFVKQLRTRTE--TDRKS--PSVSLSQSKEGTLDSKHQK---YSA 1524
            .|..|.    |...|:.||....:|.:.:..  .|:|.  |..:.....|..||::.:|   ...
  Fly   472 AAAAACNRQPLQQQQQPHLHQKQQQAKPKKVWFCDKKKLFPLKARIVELESALDNERKKTEELQC 536

Human  1525 SYDS--------YSESSGYKN--HDRRS------SSGSSRQE--SPSVPS---------CKENEK 1562
            |.|.        .::|..||.  ||..|      |:..|.|.  .|.:||         .|..||
  Fly   537 SIDEAQFCGDELNAQSQVYKEKIHDLESKITKLVSATPSLQSILPPDLPSDDGALQEEIAKLQEK 601

Human  1563 -KLNGEKIESSIDEQVQTAADDSLR------SDSVPSLPDE-----KETGSCSVTQAGLELLASR 1615
             .:..:::||.|.||::  .:..||      ::.:.:|..|     :.....|:::.|:|.| .|
  Fly   602 MTIQQKEVESRIAEQLE--EEQRLRENVKYLNEQIATLQSELVSKDEALEKFSLSECGIENL-RR 663

Human  1616 DPPTLASQNAGITDSTSIATEYSLKFDESMTEDEIEEQSFRSLLPSESHRRFNMEKRRGHHDDSD 1680
            :...|..:|      ...|.|...:|...:.|..:|.....|.|.:......::|..|.:..|..
  Fly   664 ELELLKEEN------EKQAQEAQAEFTRKLAEKSVEVLRLSSELQNLKATSDSLESERVNKTDEC 722

Human  1681 EEASPE-KTTLSTAKELNMPFSGGQDSFSKFTMEMVRQYMKEEEMRAAHQSSLLRLREK------ 1738
            |....| :......:|||.            .::.|...:..::..::....:|||:::
  Fly   723 EILQTEVRMRDEQIRELNQ------------QLDEVTTQLNVQKADSSALDDMLRLQKEGTEEKS 775

Human  1739 ALKEKTKAELAWLEHQ-KKHLRDKGEDDKMPPLRKKQRGLLLRLQQEKAEIKRLQEANKAARKER 1802
            .|.|||:.||...:.| .|.|.||.:                 |:::.:::|:|.|..|..|:..
  Fly   776 TLLEKTEKELVQSKEQAAKTLNDKEQ-----------------LEKQISDLKQLAEQEKLVREMT 823

Human  1803 QLILKQ-QEEIEKIRQTTIKLQEKLKSAGESKLDSHSDDDTKDNKATSPGPTDLETRSPSPISIS 1866
            :..:.| |.|.|.|.|.....|.:|:..  .|..|.|:...::.||.:. ..|.|.       :.
  Fly   824 ENAINQIQLEKESIEQQLALKQNELEDF--QKKQSESEVHLQEIKAQNT-QKDFEL-------VE 878

Human  1867 SSETSSIMQKLKKMRSRMDEKHCSPVHYFFSVFTSHHWASLSVCFPNLHPKFQLYIYNQLVR--- 1928
            |.|:      |||::.::::|...                        |.|.|..: .:|.:
  Fly   879 SGES------LKKLQQQLEQKTLG------------------------HEKLQAAL-EELKKEKE 912

Human  1929 -FLTKREQKLMQRRQHAEELLEWKRRLDAEEAEIRQMEKQALAAWDKELIKPKTPKKELEDQRTE 1992
             .:.::||:|.|.:..:.|.   :..|...:.::.|:::||.|:.::   ..||..| |.|:.::
  Fly   913 TIIKEKEQELQQLQSKSAES---ESALKVVQVQLEQLQQQAAASGEE---GSKTVAK-LHDEISQ 970

Human  1993 QKEIASEEESPVPLYSHLNSESSIPEELGSPAVEYVPSESIGQEQPGSPDHSILTEEMICSQELE 2057
            .|..|.|.:|.:.     :::|::  |..|..:|                        ..:..||
  Fly   971 LKSQAEETQSELK-----STQSNL--EAKSKQLE------------------------AANGSLE 1004

Human  2058 SSTSPSKHSLPKSCTSVSKQESSKGSHRTG-GQCHLPIKSHQHCYSWSD---ESLSMTQSETTSD 2118
            .....|.|.|.:    ::|.:|..|..:.. ..||..::|.......::   |.::...:|:.::
  Fly  1005 EEAKKSGHLLEQ----ITKLKSEVGETQAALSSCHTDVESKTKQLEAANAALEKVNKEYAESRAE 1065

Human  2119 QSDIEGRIRALKD----ELRKRKSVVNQLKKEQKKRQKERLKAQEASLIKQLESYDEFIKKTEAE 2179
            .||::.:::.:.|    ||:..:|..:.|..:..|...| :......|..:.:::.:.:.:.|.|
  Fly  1066 ASDLQDKVKEITDTLHAELQAERSSSSALHTKLSKFSDE-IATGHKELTSKADAWSQEMLQKEKE 1129

Human  2180 LS---QDLETSPTAKPQIKTLSSASEKPKIKPLTPLHRSETAKNWKSLTESERSRGSLESIAEHV 2241
            |.   |.|:.|..::.::|......||...:.:..|....|....::|..|..::.:::.:.|.:
  Fly  1130 LQELRQQLQDSQDSQTKLKAEGERKEKSFEESIKNLQEEVTKAKTENLELSTGTQTTIKDLQERL 1194

Human  2242 DASLSGSERSVSERSLSAYAKRVNEWDSRTEDFQTPSPVLRSSRKIREESGDSLENVPALHLLK- 2305
            :  ::.:|....|:..|..|:::.:..:..|..|..:..:         |..:.|....|.:|:
  Fly  1195 E--ITNAELQHKEKMASEDAQKIADLKTLVEAIQVANANI---------SATNAELSTVLEVLQA 1248

Human  2306 ELNATSRILDMSDGKVGESSK---------KSEIKEIEYTKLKKSKIEDAFSKEGKSDVLLKLVL 2361
            |.:.|:.|.::.:.:...:|:         |.|:||   |.|:..:.:..|.:       |:..|
  Fly  1249 EKSETNHIFELFEMEADMNSERLIEKVTGIKEELKE---THLQLDERQKKFEE-------LEEKL 1303

Human  2362 EQGDSSEILSKKDLPLDSENVQKDLVGLAIENLHKSEEMLKERQSDQDMNHSPNIQSGKDIHEQK 2426
            :|...||    :.|..:|:..::.|..:. ::|.:.::.:|::: :...|....::....|.|.:
  Fly  1304 KQAQQSE----QKLQQESQTSKEKLTEIQ-QSLQELQDSVKQKE-ELVQNLEEKVRESSSIIEAQ 1362

Human  2427 NTK--EKDLSWSEHLFAPKEIPYSEDFEVSSFKKEISAELYKDDFEVS-SLLSLRKDSQSCRDKP 2488
            |||  |.::.........||   ::|..:.|.|||  .:|.::..::| .|..:::.:...:|
  Fly  1363 NTKLNESNVQLENKTSCLKE---TQDQLLESQKKE--KQLQEEAAKLSGELQQVQEANGDIKD-- 1420

Human  2489 QPMRSSTSGATSFGSNEEISECLSEKSLSIHSNVHSDRLLELKSPTELMKSKERSDVEHEQQVTE 2553
                       |....||:.:.|.||..:..|.:.:.:....:....|:||:|..
  Fly  1421 -----------SLVKVEELVKVLEEKLQAATSQLDAQQATNKELQELLVKSQENE---------- 1464

Human  2554 SPSLASVPTADELFDFHIGDRVLIGNVQPGILRFKGETSFAKGFWAGVELDKPEGNNNGTYDGIA 2618
                                    ||:|       || |.|    ...:|.:.|..|....:.:
  Fly  1465 ------------------------GNLQ-------GE-SLA----VTEKLQQLEQANGELKEAL- 1492

Human  2619 YFECKEKHGIFAPPQKISHIPENFDDYVDINEDEDCYSDERYQCYNQEQNDTEGPKDREKDVSEY 2683
               |::::|:                                       .:.:|..|....|.|
  Fly  1493 ---CQKENGL---------------------------------------KELQGKLDESNTVLE- 1514

Human  2684 FYEKSLPSVND-IEASVNRSRSLKIETDNV-QDISGVLEAHVHQQSSVDSQISSKENKDLISDAT 2746
            ..:||...:.| :|.:..:.|:|:.||..: :.:|.:.:|:...|.|:       :.|.|:   .
  Fly  1515 SQKKSHNEIQDKLEQAQQKERTLQEETSKLAEQLSQLKQANEELQKSL-------QQKQLL---L 1569

Human  2747 EKVSIAAEDDTLDNTFSEELEKQQQFTEEEDNLYAEASEKLCTPLLDLLTREKNQLEAQL----- 2806
            ||          .|.|..:|.:.|:..:|.|:   .||.|  :.||:.|.....:||..|
  Fly  1570 EK----------GNEFDTQLAEYQKVIDEMDD---AASVK--SALLEQLQNRVAELETALRQAND 1619

Human  2807 --KSSLNEEKKSKQQLEKISLLTDSLLKVFVKDTVNQLQQIKKTRDEKIQL---SNQELLGDDQK 2866
              |::..|.|:.::|||.:                 :|::.::....|.|:   |::...||:.:
  Fly  1620 AQKTAYLETKELRRQLESL-----------------ELEKSREVLSLKAQMNGASSRSGKGDEVE 1667

Human  2867 KVTPQDLSQNVEEQSPSISGCFLSSELEDE-------KEEISSPDMCP----RPESPVFGASGQE 2920
                   |.::|.....|:  ||:|.:.|.       |.::.:.:..|    :|.:  |.|..:.
  Fly  1668 -------SLDIETSLAKIN--FLNSIIADMQQKNDALKAKVQTLETLPMDFTKPHA--FDALTKR 1721

Human  2921 ELAKRLAELELSREFLSALGDD---QDWFDEDFGLSSSHKIQKNKAEETIVPLMAEPKRVTQQPC 2982
            :.|.||. .::..||.....:|   |...|:|:...||.  ..|..:|..:|   .|::.    |
  Fly  1722 KPAPRLF-CDICDEFDQHDTEDCPIQGSEDQDYSTPSSE--SNNNEKERKLP---APRKY----C 1776

Human  2983 ETLLAVPHTAEE 2994
            ::.....|...|
  Fly  1777 DSCEVFGHDTSE 1788

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CEP350	XP_047291332.1	PRK12704	1713..>1815	CDD:237177	25/109 (23%)
		NIP100	2571..>2854	CDD:227569	55/291 (19%)
		CAP_GLY	2571..2635	CDD:460154	12/63 (19%)
CLIP-190	NP_001368962.1	PHA03307	<2..>118	CDD:223039	23/109 (21%)
		CAP_GLY	125..189	CDD:460154	15/73 (21%)
		CAP_GLY	239..306	CDD:460154	6/66 (9%)
		SMC_prok_B	<546..912	CDD:274008	92/444 (21%)
		SMC_prok_B	743..1596	CDD:274008	206/1111 (19%)
		COG4913	<1534..>1703	CDD:443941	47/219 (21%)
		CLIP1_ZNF	1726..1743	CDD:465212	4/17 (24%)
		CLIP1_ZNF	1773..1789	CDD:465212	3/20 (15%)