DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment FARP2 and shk2

DIOPT Version :9

Sequence 1:	XP_011510535.1	Gene:	FARP2 / 9855	HGNCID:	16460	Length:	1061	Species:	Homo sapiens
Sequence 2:	NP_592864.1	Gene:	shk2 / 2541468	PomBaseID:	SPAC1F5.09c	Length:	589	Species:	Schizosaccharomyces pombe

Alignment Length:	124	Identity:	31/124 - (25%)
Similarity:	57/124 - (45%)	Gaps:	16/124 - (12%)

- Green bases have known domain annotations that are detailed below.

Human   940 SGY-LLRKFKNSH-GWQKLWVVFTNFCLFFYKTHQDDYPLASLPLLGYSVSIPREADGIHKDYVF 1002
            ||: :|::.|..: .|.|.|:|.::..|..||..:.:....:| ||.....:.|...   :.:.|
pombe    27 SGWVMLKEDKMKYLPWTKKWLVLSSNSLSIYKGSKSESAQVTL-LLKDIQKVERSKS---RTFCF 87

Human  1003 KLQFKSHVYFFR--------AESKYTFERWMEVIQGASSSAGRAPSIVQDGPQPSSGLE 1053
            ||:|||....|.        |::...:| ||::| .:.:.|.:..|.:....|...|::
pombe    88 KLRFKSSTKNFEIQACELSVADNMECYE-WMDLI-SSRALASKVSSPMNPKHQVHVGID 144

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
FARP2	XP_011510535.1	B41	45..234	CDD:214604
		FERM_C_FARP1-like	221..341	CDD:270014
		FA	333..375	CDD:312314
		Herpes_ICP4_C	358..>533	CDD:332854
		RhoGEF	537..720	CDD:238091
		PH1_FARP1-like	749..862	CDD:269928
		PH2_FARP1-like	935..1032	CDD:270055	27/101 (27%)
shk2	NP_592864.1	PH_Cla4_Ste20	24..120	CDD:270097	26/97 (27%)
		PBD	128..182	CDD:279166	3/17 (18%)
		STKc_PAK	308..567	CDD:270789
		S_TKc	309..566	CDD:214567
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910