Protein Alignment FARP2 and fab1

DIOPT Version :9

• Sequence 1: XP_011510535.1
• Gene: FARP2 / 9855
• HGNCID: 16460
• Length: 1061
• Species: Homo sapiens
• Sequence 2: NP_596090.2
• Gene: fab1 / 2541154
• PomBaseID: SPBC3E7.01
• Length: 1932
• Species: Schizosaccharomyces pombe
• Alignment Length: 944
• Identity: 163/944 - (17%)
• Similarity: 301/944 - (31%)
• Gaps: 386/944 - (40%)

Human    28 TLEPGQTLLPRMQEKHLHLRVKLLDNTMEIFDIEPKCDGQVLLTQVWKRLNLVECDYFGMEFQNT 92
            ||....:.:..::||    ..|.|...:|      ||     |:.|..|:|.::||
pombe  1098 TLRNNPSYIKELKEK----EYKRLKGVIE------KC-----LSSVASRINQIKCD--------- 1138

Human    93 QSYWIWL---EPMKPIIRQIRRPKNVVLRLAVKFFPPDPGQLQEEYTRYLFALQLKRDLLEERLT 154
                 |:   |..:....:|.:.:.:               |..:||.    |..:.|.:....:
pombe  1139 -----WVTDPEKFESCTSEISKFRTL---------------LSSDYTE----LYSEFDSIYLNSS 1179

Human   155 CADTTAALLTSHLLQSEIGDYDET-LDREHLKVNEYLPGQQHCLEKILE------FHQKHVGQTP 212
            .:|..:......:||.::..:::. ||.:.|    |||..:. |.||..      |.::.:.|||
pombe  1180 TSDYLSLNSILRVLQGKMVKWEQRFLDYQRL----YLPSYKE-LSKIAAAQIKKVFLERPLSQTP 1239

Human   213 AESDFQVLEIARKLEMYGIRFHMASDREGTKIQLAVSHMGVLVFQGTTKINTFNWSKVRKLSFKR 277
                   |::...||...|..:.:...|.|..||          :..|:.|..:..:|
pombe  1240 -------LDLPETLENTQIDIYPSFKTESTDDQL----------EKVTQTNVASNKRV------- 1280

Human   278 KRFLIKLHPEVHGPYQDTLEFLLGSRDECKNFWKICVEYHTFFRLLDQPKPKAKAVF-------- 334
                        .||.|::..:.....:|            |........|||...|
pombe  1281 ------------APYADSMANVGSPESDC------------FSVATSSDIPKANIDFTNDISTQN 1321

Human   335 -----------FSRGSSFRYSGRTQKQLVDYFKDSGMKRIPYERRHSKTHTSVRALTADLPKQSI 388
                       |||.:   |...:|:|        |:..:.::|:        .|.|:|....:.
pombe  1322 TFPASPVSNSGFSRQT---YPNISQRQ--------GVNMLSHKRK--------SASTSDRRFVNA 1367

Human   389 SFPEGLRTPASPSSANAFYSLSPST---------------------------------------- 413
            |...|:..|.|.|.:....|:..||
pombe  1368 SSTSGMNMPISSSISAKISSIQNSTKYSPRKPIPAKDVRVSSLVRRFEELSLQLQEKQKRDEELI 1432

Human   414 ---------LVPS-----------------------GLPEFKDSSSSLTDPQVSYVKSPAAERRS 446
                     :|||                       |:.:.|::.:  |:...|.|.|.:.||.:
pombe  1433 KARRKRALPVVPSKPVVEVFNDLNEAFDDENSEDENGINDTKENRA--TESNFSGVDSMSKEREN 1495

Human   447 GAVAGGPD-TPSA------------------QPLGPPALQPGPGLSTKSPQPSPSSRKSPL---- 488
              |:...| :|.|                  |.|.|.:.....|  :|.|...|.:.|:.:
pombe  1496 --VSSNEDNSPEAFEDIFGILFKNESGLEEQQNLEPSSQMDKEG--SKLPTSGPLADKTSVYRIL 1556

Human   489 --------SLS-PAFQVPLGPAEQGSSPLLSPVLSDAGGAGMDCEEPRHKRVPADEAYFIVKEIL 544
                    ||: |.|:.||.|.|.        :.||:
pombe  1557 SAFWNEWNSLNPPPFEFPLQPTEH--------MFSDS---------------------------- 1585

Human   545 ATERTYLKDLEVITVWFRSAVVKEDAMPATLMTLLFSNIDPIYEFHRGFLREVEQRLALWEGPSK 609
                              :.:::||. |::|::...|:.|.:.:     :.|:|.  ::.|..:.
pombe  1586 ------------------NVIIREDE-PSSLISFTLSSPDYLSK-----MVEIED--SMDEALTN 1624

Human   610 AHTKGSHQ-RIGDILLR----NMR-QLKEFTS------YFQRHDEVLTELEKA----------TK 652
            ...:||.| :|.:::|:    ::: |.:|.::      :|.   |..:.|.:|          ..
pombe  1625 QGLQGSTQFKIENLMLKPTGTHLKYQFEEGSARLSCKVFFA---EQFSALRRACGCEETFVTSLA 1686

Human   653 RC--------KKLEAVYKEFELQKVCYLPLNTFLLKPIQRLLHYRLLLRRLCGHYSPGHHDYAD- 708
            ||        |...|..|.|:         ..::||.:.||....||      :::|.:.||..
pombe  1687 RCSLWESSGGKSGSAFLKTFD---------KKYILKVLSRLESDSLL------NFAPAYFDYISK 1736

Human   709 --CHDALKAITEVTTTLQHILIRLENLQKLTELQRDLVGIENLI---APGREFIREGCLH----- 763
              .|:...|:|::   .....:.:.|....|..:.|::.:||:.   .|.|.|..:|.:.
pombe  1737 VFFHELPTALTKI---FGFYRVDIRNPTTGTICKTDIMIMENVFYDECPSRIFDLKGSMRNRHVE 1798

Human   764 ---KLTKKGLQQRMFFLFSDMLLYTSKGVAGTSH 794
               |:.:..|.:.:..|..:..::.|:.:....|
pombe  1799 STGKVDEVLLDENLVELIYESPIFVSEQLKSLLH 1832

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
FARP2	XP_011510535.1	B41	45..234	CDD:214604	39/198 (20%)
		FERM_C_FARP1-like	221..341	CDD:270014	22/138 (16%)
		FA	333..375	CDD:312314	9/60 (15%)
		Herpes_ICP4_C	358..>533	CDD:332854	46/278 (17%)
		RhoGEF	537..720	CDD:238091	38/215 (18%)
		PH1_FARP1-like	749..862	CDD:269928	9/57 (16%)
		PH2_FARP1-like	935..1032	CDD:270055
fab1	NP_596090.2	FYVE	54..120	CDD:214499
		Fab1_TCP	477..738	CDD:239450
		MSS4	1322..1932	CDD:227578	104/619 (17%)
		PIPKc	1599..1917	CDD:238081	48/262 (18%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910