Protein Alignment ELMO1 and Ced-12

DIOPT Version :10

• Sequence 1: NP_055615.8
• Gene: ELMO1 / 9844
• HGNCID: 16286
• Length: 727
• Species: Homo sapiens
• Sequence 2: NP_609548.1
• Gene: Ced-12 / 34633
• FlyBaseID: FBgn0032409
• Length: 724
• Species: Drosophila melanogaster
• Alignment Length: 740
• Identity: 344/740 - (46%)
• Similarity: 482/740 - (65%)
• Gaps: 50/740 - (6%)

Human     7 IVKVAIEWPGAYPKLMEIDQKKPLSAIIKEVCDGWSLANHEYFALQHADSSN-FYITEKNRNEIK 70
            |||:|:|......:|:.:||:.||::.|:|:|:|||:::|:.:|||..:.:| .|:|||||||||
  Fly    13 IVKIAVEREDHIAQLINLDQRHPLASKIQEICNGWSISDHQNYALQFYEPTNRKYVTEKNRNEIK 77

Human    71 NGTILRLTTSPAQNAQQLHERIQSSSMDAKLEALKDLASLSRDVTFAQEFINLDGISLLTQMVES 135
            ||::|:|..||::.|....|.:.:.|...|...||:|.|||.|.|||.|||...|:..|.:|:|.
  Fly    78 NGSVLQLQYSPSKTACDAMEVLLNGSPQEKALRLKELTSLSTDHTFALEFIKEKGLDTLIKMIED 142

Human   136 GTERYQKLQKIMKPCFGDMLSFTLTAFVELMDHGIVSWDTFSVAFIKKIASFV-NKSAIDISILQ 199
            |.:..:           |:|.::|.:|||||:||.|||:....:|:.:....| |......:..:
  Fly   143 GGQTNE-----------DILKYSLASFVELMEHGTVSWEVPENSFVARNIEIVRNFQKYPTNCGE 196

Human   200 RSLAILESMVL--NSHDLYQKVAQEITIGQLIPHLQGSDQEI-QTYTIAVINALFLKAPDERRQE 261
            .:|:.||::|:  |.|.|   ||::|.:..::..||..:..: :...||::||||:||.:.||:.
  Fly   197 SALSNLENIVMCSNKHVL---VAEDIKLQDILRLLQDVNSPVMRQNAIALLNALFVKADEGRRRT 258

Human   262 MANILAQKQLRSIILTHVIRAQRAINNEMAHQLYVLQVLTFNLLEDRMMTKMDPQDQAQRDIIFE 326
            :|..::.||.|..::.:      .:..||.|||||||.||..|||.||..||:.|||...:.|.|
  Fly   259 IAQTISAKQFRLALIGN------GLGTEMTHQLYVLQTLTLGLLEKRMRMKMNAQDQDAHEKIKE 317

Human   327 LRRIAFDAESEPNN----------SSGSMEKRKSMYTRDYKKLGFINHVNPAMDFTQTPPGMLAL 381
            |||||||..:...|          .||:.....|.|   ||||||...:|||.||.:||||:|||
  Fly   318 LRRIAFDDNTNALNQNDDHIRRGGGSGAGNVNFSQY---YKKLGFKCDINPAQDFIETPPGILAL 379

Human   382 DNMLYFAKHHQDAYIRIVLENSSREDKHECPFGRSSIELTKMLCEILKVGELPSETCNDFHPMFF 446
            |.|:|||:::...|.:||.|||.|.|:|||||||:||||.|:||:||::||.|:|...||.||||
  Fly   380 DCMVYFARNYTQQYAKIVRENSCRADEHECPFGRTSIELVKVLCDILRIGEPPAEQSGDFQPMFF 444

Human   447 THDRSFEEFFCICIQLLNKTWKEMRATSEDFNKVMQVVKEQVMRALTTKPSSLDQFKSKLQNLSY 511
            |||..||||||||:..||:|||:||||:|||:....||:||:.|.|..:|.:||.|::|:..|:|
  Fly   445 THDSPFEEFFCICVITLNRTWKDMRATAEDFSTTFSVVREQIQRTLKGRPENLDDFRNKIALLTY 509

Human   512 TEILKIRQSERMNQE--DFQSRPILELKEKIQPEILELIKQQRLNRLVEGTCFRK-LNARRRQDK 573
            .:|..:||.||.::|  |..:..|::|||||.|:||||||||||:.|||||.|.| |...|.:||
  Fly   510 QQITTLRQQERTSKEECDSTASAIVKLKEKISPQILELIKQQRLSFLVEGTHFAKYLRGTRTKDK 574

Human   574 FWYCRLSPNHKVLHYGDLEESPQGEVP-HDSLQDKLPVADIKAVVTGKDCPHMKEKGALKQNKEV 637
            |||.||||||||:||||.:|.   .:| .:.|..|||:::||.::.||:||||||   .:..|..
  Fly   575 FWYARLSPNHKVIHYGDCDEK---TIPTMEELPKKLPISEIKQLLEGKECPHMKE---TRIRKSA 633

Human   638 LELAFSILYDS--NCQLNFIAPDKHEYCIWTDGLNALLGKDMMSDLTRNDLDTLLSMEIKLRLLD 700
            :.|||||.:::  :..|:|:|||:..:..||||:|||||:.|:|.....|.||||||||||||||
  Fly   634 VNLAFSITFENMEHSTLDFVAPDESIFNYWTDGINALLGQPMVSKQKNEDFDTLLSMEIKLRLLD 698

Human   701 LENIQIPDAPPPIPKEPSNYDFVYD 725
            .|.:.|...|||||::|.||||.::
  Fly   699 TEGVDISKDPPPIPEDPENYDFCFE 723

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ELMO1	NP_055615.8	ELMO_ARM	115..280	CDD:463369	53/168 (32%)
		ELMO_CED12	303..481	CDD:461411	104/187 (56%)
		PH_ELMO1_CED-12	546..675	CDD:270166	69/132 (52%)
		SH3-binding	707..714		3/6 (50%)
Ced-12	NP_609548.1	ELMO_ARM	122..277	CDD:463369	53/174 (30%)
		ELMO_CED12	295..477	CDD:461411	104/184 (57%)
		PH_ELMO1_CED-12	546..673	CDD:270166	69/132 (52%)