DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ELMO1 and Ced-12

DIOPT Version :9

Sequence 1:	NP_001193409.1	Gene:	ELMO1 / 9844	HGNCID:	16286	Length:	727	Species:	Homo sapiens
Sequence 2:	NP_609548.1	Gene:	Ced-12 / 34633	FlyBaseID:	FBgn0032409	Length:	724	Species:	Drosophila melanogaster

Alignment Length:	740	Identity:	344/740 - (46%)
Similarity:	482/740 - (65%)	Gaps:	50/740 - (6%)

- Green bases have known domain annotations that are detailed below.

Human     7 IVKVAIEWPGAYPKLMEIDQKKPLSAIIKEVCDGWSLANHEYFALQHADSSN-FYITEKNRNEIK 70
            |||:|:|......:|:.:||:.||::.|:|:|:|||:::|:.:|||..:.:| .|:|||||||||
  Fly    13 IVKIAVEREDHIAQLINLDQRHPLASKIQEICNGWSISDHQNYALQFYEPTNRKYVTEKNRNEIK 77

Human    71 NGTILRLTTSPAQNAQQLHERIQSSSMDAKLEALKDLASLSRDVTFAQEFINLDGISLLTQMVES 135
            ||::|:|..||::.|....|.:.:.|...|...||:|.|||.|.|||.|||...|:..|.:|:|.
  Fly    78 NGSVLQLQYSPSKTACDAMEVLLNGSPQEKALRLKELTSLSTDHTFALEFIKEKGLDTLIKMIED 142

Human   136 GTERYQKLQKIMKPCFGDMLSFTLTAFVELMDHGIVSWDTFSVAFIKKIASFV-NKSAIDISILQ 199
            |.:..:           |:|.::|.:|||||:||.|||:....:|:.:....| |......:..:
  Fly   143 GGQTNE-----------DILKYSLASFVELMEHGTVSWEVPENSFVARNIEIVRNFQKYPTNCGE 196

Human   200 RSLAILESMVL--NSHDLYQKVAQEITIGQLIPHLQGSDQEI-QTYTIAVINALFLKAPDERRQE 261
            .:|:.||::|:  |.|.|   ||::|.:..::..||..:..: :...||::||||:||.:.||:.
  Fly   197 SALSNLENIVMCSNKHVL---VAEDIKLQDILRLLQDVNSPVMRQNAIALLNALFVKADEGRRRT 258

Human   262 MANILAQKQLRSIILTHVIRAQRAINNEMAHQLYVLQVLTFNLLEDRMMTKMDPQDQAQRDIIFE 326
            :|..::.||.|..::.:      .:..||.|||||||.||..|||.||..||:.|||...:.|.|
  Fly   259 IAQTISAKQFRLALIGN------GLGTEMTHQLYVLQTLTLGLLEKRMRMKMNAQDQDAHEKIKE 317

Human   327 LRRIAFDAESEPNN----------SSGSMEKRKSMYTRDYKKLGFINHVNPAMDFTQTPPGMLAL 381
            |||||||..:...|          .||:.....|.|   ||||||...:|||.||.:||||:|||
  Fly   318 LRRIAFDDNTNALNQNDDHIRRGGGSGAGNVNFSQY---YKKLGFKCDINPAQDFIETPPGILAL 379

Human   382 DNMLYFAKHHQDAYIRIVLENSSREDKHECPFGRSSIELTKMLCEILKVGELPSETCNDFHPMFF 446
            |.|:|||:::...|.:||.|||.|.|:|||||||:||||.|:||:||::||.|:|...||.||||
  Fly   380 DCMVYFARNYTQQYAKIVRENSCRADEHECPFGRTSIELVKVLCDILRIGEPPAEQSGDFQPMFF 444

Human   447 THDRSFEEFFCICIQLLNKTWKEMRATSEDFNKVMQVVKEQVMRALTTKPSSLDQFKSKLQNLSY 511
            |||..||||||||:..||:|||:||||:|||:....||:||:.|.|..:|.:||.|::|:..|:|
  Fly   445 THDSPFEEFFCICVITLNRTWKDMRATAEDFSTTFSVVREQIQRTLKGRPENLDDFRNKIALLTY 509

Human   512 TEILKIRQSERMNQE--DFQSRPILELKEKIQPEILELIKQQRLNRLVEGTCFRK-LNARRRQDK 573
            .:|..:||.||.::|  |..:..|::|||||.|:||||||||||:.|||||.|.| |...|.:||
  Fly   510 QQITTLRQQERTSKEECDSTASAIVKLKEKISPQILELIKQQRLSFLVEGTHFAKYLRGTRTKDK 574

Human   574 FWYCRLSPNHKVLHYGDLEESPQGEVP-HDSLQDKLPVADIKAVVTGKDCPHMKEKGALKQNKEV 637
            |||.||||||||:||||.:|.   .:| .:.|..|||:::||.::.||:||||||   .:..|..
  Fly   575 FWYARLSPNHKVIHYGDCDEK---TIPTMEELPKKLPISEIKQLLEGKECPHMKE---TRIRKSA 633

Human   638 LELAFSILYDS--NCQLNFIAPDKHEYCIWTDGLNALLGKDMMSDLTRNDLDTLLSMEIKLRLLD 700
            :.|||||.:::  :..|:|:|||:..:..||||:|||||:.|:|.....|.||||||||||||||
  Fly   634 VNLAFSITFENMEHSTLDFVAPDESIFNYWTDGINALLGQPMVSKQKNEDFDTLLSMEIKLRLLD 698

Human   701 LENIQIPDAPPPIPKEPSNYDFVYD 725
            .|.:.|...|||||::|.||||.::
  Fly   699 TEGVDISKDPPPIPEDPENYDFCFE 723

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ELMO1	NP_001193409.1	DUF3361	116..279	CDD:403139	52/166 (31%)
		ELMO_CED12	303..481	CDD:398415	104/187 (56%)
		PH_ELMO1_CED-12	546..675	CDD:270166	69/132 (52%)
		SH3-binding	707..714		3/6 (50%)
Ced-12	NP_609548.1	DUF3361	122..275	CDD:288674	53/166 (32%)
		ELMO_CED12	296..474	CDD:282570	100/180 (56%)
		PH_ELMO1_CED-12	546..673	CDD:270166	69/132 (52%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	206	1.000	Domainoid score	I2908
eggNOG	1	0.900	-	-		E1_KOG2999
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H56685
Inparanoid	1	1.050	622	1.000	Inparanoid score	I876
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG52862
OrthoDB	1	1.010	-	-		D177102at33208
OrthoFinder	1	1.000	-	-		FOG0001427
OrthoInspector	1	1.000	-	-		otm41511
orthoMCL	1	0.900	-	-		OOG6_102058
Panther	1	1.100	-	-	O	PTHR12771
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2448
SonicParanoid	1	1.000	-	-		X1314
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	15	14.870