Protein Alignment PLEKHM1 and Plekhm1

DIOPT Version :9

• Sequence 1: NP_055613.1
• Gene: PLEKHM1 / 9842
• HGNCID: 29017
• Length: 1056
• Species: Homo sapiens
• Sequence 2: NP_611639.1
• Gene: Plekhm1 / 37520
• FlyBaseID: FBgn0034694
• Length: 720
• Species: Drosophila melanogaster
• Alignment Length: 1065
• Identity: 232/1065 - (21%)
• Similarity: 370/1065 - (34%)
• Gaps: 403/1065 - (37%)

Human    17 VIKKKLVGSVK------ALQKQYVSLDTVVTSEDGDANTMCSALEAVFIHGLHAKHIRAE----A 71
            |:|:.|:.::.      ..:.:..||:.:...|...|  :|:.|||:|:|||....:.|.    |
  Fly    18 VVKEALINTLNENAREIEFEVKQKSLEVLGVCEQTSA--LCTTLEALFLHGLKDSFLSATFNVIA 80

Human    72 GGKRKKSAHQKPLPQPVFWPLLKAVTHKHIISELEHLTFVNTDVGRCRAWLRLALNDGLMECYLK 136
            |...::       |:|.||.......||.:|.:::.|:.:.::.|:||||:|.:||:.:...||.
  Fly    81 GDVERR-------PEPSFWAPCMVFMHKQVIEQVQGLSQITSETGQCRAWVRQSLNESVFSSYLN 138

Human   137 LLLQEQARLHEYYQPTALLRDAEEGEFLLSFLQGLTS-LSFELSYKSAILNEWTLTPLALSGL-- 198
            .:.:..:.|.:||:..||:||:|..|.....::.|.: :.|:|...|::||.|....|.||.|
  Fly   139 NMRKNGSALSQYYKRNALMRDSEGLETAAKIMESLEAYVQFDLPVNSSLLNHWPDYSLQLSDLWT 203

Human   199 -----CPLSELDPLSTSGAELQRKESLDSISHSSGSEDIEVHHSGHKIRRNQKLTASSLSLDTAS 258
                 ||:|       ||.:         ::.|.||:.|       .|...|.|..:.|..::.|
  Fly   204 PALKSCPIS-------SGVD---------VASSLGSDII-------AIPTPQPLQTNELFSESIS 245

Human   259 SSQLSCSLNSDSCLLQENGSKSPDHCEEPMSCDSDLGTANAEDSDRSLQEVLLE-FSKAQV-NSV 321
            :|                          |...:|:.|.  .|.|.|...::|:: |.:..| |..
  Fly   246 NS--------------------------PFGRNSNFGV--PELSQRENLDLLIQKFDEMDVINEE 282

Human   322 PTNGLSQETEIPTPQASLSLHGLNTSTYLHCEAPAEPLPAQAASGTQDGVHVQEPRPQAPS---P 383
            .|.|...||.....|                |||         ||::.....:..|....|   .
  Fly   283 QTGGDKAETNETAEQ----------------EAP---------SGSKTRSRKKSNRQMDSSSFAD 322

Human   384 LDLQQPVESTSGQQPSSTVSETAREVGQGNGLQKAQAHDGAGLKLVVSSPTSPKNKSWISEDDFY 448
            |||:.|.....|....|.:.:|:   ..|:               :.::||||..:  ::...|:
  Fly   323 LDLEAPSLLPQGSNSLSNLMQTS---WSGD---------------LEATPTSPTEE--LTGSRFF 367

Human   449 RPSREQPLESASDHPIASYRGTPGSRPGLHRHFSQEPRKNCSLGALDQACVPSPGRRQAQAAPSQ 513
            :       .|.|.....|.|.....|              ||..||                 .:
  Fly   368 Q-------RSVSVSSSVSLRSPTTDR--------------CSYNAL-----------------LR 394

Human   514 GHKSFRVVHRRQMGLSNPFRGLMKLGTVERRGAMGIWKELFCELSPLEFRLYLSNEEHTCVENCS 578
            .|:|     .|:.|..                    |.|::     .:||...||
  Fly   395 KHES-----NRESGAG--------------------WSEIW-----EKFRASASN---------- 419

Human   579 LLRCESVGPAHSDGRFELVFSGKKLALRASSQDEAEDWLDRVREALQKVRPQQEDEWVNVQYPDQ 643
                                                                     :||..|.:
  Fly   420 ---------------------------------------------------------LNVAQPQR 427

Human   644 PEEPPEAPQGCLSPSDLLSEPAALQGTQFDWSSAQVPEPDAIKESLLYLYMDRTWMPYIFSLSLE 708
            ..:||            :||.
  Fly   428 DTDPP------------ISED-------------------------------------------- 436

Human   709 ALKCFRIRNNEKMLSDSHGVETIRDILPDTSLGGPSFFKIITAKAVLKLQAGNAEEAALWRDLVR 773
                         |||...::|            .|.|:::|::.                |:|.
  Fly   437 -------------LSDLQSLDT------------NSEFELLTSEF----------------DMVE 460

Human   774 KVLASYLETAEEAVTLGGSLDENCQEVLKFATRENGFLLQYLVA----IPMEKGLDSQGCFCAGC 834
                                                  ||.:||    :..|.|||:||..|..|
  Fly   461 --------------------------------------LQQMVAQLCQLAREPGLDAQGFLCKSC 487

Human   835 SRQIGFSFVRPKLCAFSGLYYCDICHQDDASVIPARIIHNWDLTKRPICRQALKFLTQIRAQPLI 899
            ...:|..:...::|||||.|||:.|...:..:||||||:|||..|..:.::|..||.:.|:.|.:
  Fly   488 QHPLGIGYSNFQVCAFSGSYYCNSCMDVEMQLIPARIIYNWDFRKYSVSKRAATFLAEFRSHPFL 552

Human   900 NLQMVNASLYEHVERMHLIGRRREQLKLLGDYLGLCRSGALKELSKRLNHRNYLLESPHRFSVAD 964
            ::|::|..:|...:.|..:...|.:|..:..||..|...:::.|..:...|.||.|..|.:|:||
  Fly   553 DMQLLNPRIYFASDAMAELQSLRIRLNFIRAYLYTCAPSSIELLQNQFAGREYLYEHIHLYSIAD 617

Human   965 LQQIADGVYEGFLKALIEFASQHVYHCDLCTQRGFICQICQHHDIIFPFEFDTTVRCAECKTVFH 1029
            |..|..||....|:...:....||..|.||..:||||:|||...:::||...||.||..|..|||
  Fly   618 LALIQRGVLCQQLQKAFKLGEAHVLKCRLCHLKGFICEICQSPRVLYPFHISTTFRCLACGAVFH 682

Human  1030 QSCQAVVKKGCPRCARRRKYQEQNI 1054
            ..| ...|:.||:|.|.||.::|.:
  Fly   683 AEC-LNEKQPCPKCERIRKREDQGL 706

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PLEKHM1	NP_055613.1	RUN	49..182	CDD:280855	41/137 (30%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	215..245		5/29 (17%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	277..303		4/25 (16%)
		Caprin-1_C	306..>463	CDD:289087	31/161 (19%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	360..422		12/64 (19%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	451..483		5/31 (16%)
		PH_PLEKHM1	499..629	CDD:241475	10/129 (8%)
		LIR. /evidence=ECO:0000305	632..638		0/5 (0%)
		Interaction with RAB7A. /evidence=ECO:0000269|PubMed:25500191	654..1056		102/405 (25%)
		PH	685..777	CDD:214574	9/91 (10%)
		zf-RING_9	846..1048	CDD:290612	75/201 (37%)
Plekhm1	NP_611639.1	RUN	54..185	CDD:280855	42/139 (30%)
		zf-RING_9	500..700	CDD:290612	75/200 (38%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165144815
Domainoid	1	1.000	193	1.000	Domainoid score	I3193
eggNOG	1	0.900	-	-		E1_KOG1829
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	282	1.000	Inparanoid score	I2892
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D177737at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm40872
orthoMCL	1	0.900	-	-		OOG6_109012
Panther	1	1.100	-	-	LDO	PTHR12326
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5810
SonicParanoid	1	1.000	-	-		X6907
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	13	12.790