DRSC/TRiP Functional Genomics Resources

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Protein Alignment ZBTB24 and AZF1

DIOPT Version :9

Sequence 1:NP_055612.2 Gene:ZBTB24 / 9841 HGNCID:21143 Length:697 Species:Homo sapiens
Sequence 2:NP_014756.3 Gene:AZF1 / 854280 SGDID:S000005639 Length:914 Species:Saccharomyces cerevisiae


Alignment Length:575 Identity:133/575 - (23%)
Similarity:216/575 - (37%) Gaps:136/575 - (23%)


- Green bases have known domain annotations that are detailed below.


Human   127 DFQNNHSSPKPTTLNTAGAPVVVISNKKNDPPKRKRGRPKKVNTLQEEKSELAAEE--------- 182
            |..||:::......|...      ::..||............|...:|...||:.:         
Yeast   359 DSSNNNNNNNNNNNNENN------NDNNNDNNDNSINSATSTNIPNQEDHSLASTDTTSNSRKDL 417

Human   183 -EIQLRVNNSVQNRQNF------------VVKGDSGVLNEQI--------AAKEKEESEPTCEPS 226
             ||:.|:...:.:..|:            |::|..| ||:.|        ..|::::.:.|....
Yeast   418 KEIEQRLRKHLNDEDNYSSAISRPLDKNDVIEGSEG-LNKHIDESGMQPNIIKKRKKDDSTVYVK 481

Human   227 RE---EEMPVEKDENYDPKTEDGQASQSRYSKRRIWRSVKLKDYKLVGDQEDHGSAKRICGRRKR 288
            .|   .:.|:.||.:    |....|:.:.:|    .:...:.|...|.|     .|..:.|    
Yeast   482 NEMPRTDPPMSKDNS----TSAEGAAMANFS----GKEPPIPDISSVSD-----DATNLIG---- 529

Human   289 PGGPEARCKDCGKVFKYNHFLAIHQRSHTGERPFKCNECGKGFAQKHSLQVHTRMHTGERPYTCT 353
                         ..|.:..:.|.|...            |||.:|    |:| ...|:..:..|
Yeast   530 -------------ATKVDQLMLIIQARK------------KGFTEK----VNT-TQDGDLLFNQT 564

Human   354 VCSKALTTKHSLLEHMSLHSGQKSFTCDQCGKYFSQN-RQLKSHYRVHTGHSLPECKDCHRKFMD 417
            :  ..|..|..|:..:....|             :|| |.:|.|          ||..|||.|..
Yeast   565 M--DILPPKSELVGGVEKPKG-------------TQNTRAVKKH----------ECPYCHRLFSQ 604

Human   418 VSQLKKHLRTHTGEKPFTCEICGKSFTAKSSLQTHIRIHRGEKPYSCGICGKSFSDSSAKRRHCI 482
            .:.|:.|:|:|.|.|||.|:.|||.||...:|:||.|:|.|||||||.||.|.||.......|.:
Yeast   605 ATHLEVHVRSHIGYKPFVCDYCGKRFTQGGNLRTHERLHTGEKPYSCDICDKKFSRKGNLAAHLV 669

Human   483 LHTGKKPFSC--PECNLQFARLDNLKAHL-KIHSKEKHASDA--SSISGSSNTE-EVRNILQ--L 539
            .|...|||.|  ..||..|.:|.|:|||. :.|.:..:|..|  :.::.|.|.. |.|.:|:  .
Yeast   670 THQKLKPFVCKLENCNKTFTQLGNMKAHQNRFHKETLNALTAKLAEMNPSENIPLEERQLLEYFA 734

Human   540 QPYQLSTSGEQ--------EIQLLVTDSVHNINFMPGPSQGISIVTAESSQNMTADQAANLTLLT 596
            ..|:.|..|.:        :...:.:...|..:.:..|:...:...|..|:| ..:...|:...:
Yeast   735 SIYKNSNRGIKGRGKGVGTKKSTISSPENHPASTILNPNTNANNAIANDSEN-NGNPEGNIDSSS 798

Human   597 QQPEQLQNLILSAQQE----QTEHIQSLNMIESQMGPSQTEPVHVITLSKETLEH 647
            .......::|...|::    |::.||  |...:.:..|......:|..:..||.|
Yeast   799 NSNPGSHSMISPTQKDMGTLQSQFIQ--NNFNNSVNSSNPSNQPIINYNYTTLPH 851

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ZBTB24NP_055612.2 BTB 27..133 CDD:306997 3/5 (60%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 131..176 6/44 (14%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 209..254 9/55 (16%)
C2H2 Zn finger 296..316 CDD:275368 3/19 (16%)
COG5048 <321..480 CDD:227381 54/159 (34%)
C2H2 Zn finger 324..344 CDD:275368 6/19 (32%)
C2H2 Zn finger 352..372 CDD:275368 4/19 (21%)
C2H2 Zn finger 380..400 CDD:275368 5/20 (25%)
C2H2 Zn finger 408..428 CDD:275368 8/19 (42%)
C2H2 Zn finger 436..456 CDD:275368 10/19 (53%)
C2H2 Zn finger 464..480 CDD:275368 6/15 (40%)
C2H2 Zn finger 492..512 CDD:275368 9/22 (41%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 652..697
AZF1NP_014756.3 COG5048 342..768 CDD:227381 117/487 (24%)
C2H2 Zn finger 595..615 CDD:275368 8/19 (42%)
C2H2 Zn finger 623..643 CDD:275368 10/19 (53%)
C2H2 Zn finger 651..671 CDD:275368 7/19 (37%)
C2H2 Zn finger 679..702 CDD:275368 9/22 (41%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.910

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