DRSC/TRiP Functional Genomics Resources

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Protein Alignment ZBTB24 and ttk

DIOPT Version :9

Sequence 1:NP_055612.2 Gene:ZBTB24 / 9841 HGNCID:21143 Length:697 Species:Homo sapiens
Sequence 2:NP_001189329.1 Gene:ttk / 48317 FlyBaseID:FBgn0003870 Length:813 Species:Drosophila melanogaster


Alignment Length:850 Identity:167/850 - (19%)
Similarity:271/850 - (31%) Gaps:306/850 - (36%)


- Green bases have known domain annotations that are detailed below.


Human    19 HSDTVLASFEDQRKKGFLCDITLIVENVHFRAHKALLAASSEYFSMMFAEEGEIGQSIYMLEGMV 83
            |...:|:.|:.........|:||.||..|.:|||.:|:|.|.||:.:|....| ...|.:|:.:.
  Fly    15 HQSNLLSVFDQLLHAETFTDVTLAVEGQHLKAHKMVLSACSPYFNTLFVSHPE-KHPIVILKDVP 78

Human    84 ADTFGILLEFIYTGYLHASEKSTEQILATAQFLKVYD--LVKAYTDFQNNHSSP----------- 135
            ......||:|:|.|     |.|.:|...|| ||:|.:  .:|..|:..::..||           
  Fly    79 YSDMKSLLDFMYRG-----EVSVDQERLTA-FLRVAESLRIKGLTEVNDDKPSPAAAAAGAGATG 137

Human   136 KPTTLNT------------------AGAPVVVISNKKNDP--------------PKRKRGRPKKV 168
            ..:|..|                  ||..:...:|..|.|              ||||||||:|:
  Fly   138 SESTATTPQLQRIQPYLVPQRNRSQAGGLLASAANAGNTPTLPVQPSLLSSALMPKRKRGRPRKL 202

Human   169 NTLQEEKSELAAEEEIQLRVNNSVQNRQNFVVKGDSGVLNEQIAAKE--KEESEPTCEPSREEEM 231
            :...........:.:.:..:|:|..       .|:..:.||..:..:  .::::|..        
  Fly   203 SGSSNGTGNDYDDFDRENMMNDSSD-------LGNGKMCNESYSGNDDGSDDNQPNA-------- 252

Human   232 PVEKDENYDPKTED-GQASQSRYSKRRIWRSVKLKDYKLVGDQEDHGS-----------AKRICG 284
                     ..|:| .::..|..||    ||...||:::|...||:.:           ::|:.|
  Fly   253 ---------GHTDDLNESRDSLPSK----RSKNSKDHRVVSHHEDNSTSVTPTKATPELSQRLFG 304

Human   285 ------------------------------RRKRP----------------------GGPEARCK 297
                                          |...|                      |.|:...|
  Fly   305 SSSTTISATAPGGSSTGPSETISLLEISDERESAPVHLPTILGLKIRAINTTTPAQQGSPQTPTK 369

Human   298 DCGKVFK------YNHFL---------------------------AIHQRSHTGERPFK----CN 325
            ...|:.:      .|..|                           |::....:.|.|.|    .|
  Fly   370 SKPKIRQATGSNNSNSLLKQQLRGGAKDPEVPPATRITGAVTPNAALNAEEQSKEMPKKNQDEVN 434

Human   326 ECGKGFAQKHSLQVHTRMHTGERPYTCTVCSKALTTKHSLLEHMSLHSG----------QKSFTC 380
            .|         :.:|:..:..|: ....|.|.. ...|.||.||:.::.          |:..:.
  Fly   435 AC---------IGLHSLANAAEQ-QAAQVASTG-NLHHQLLLHMAANNSMLNTTDYYQQQQQESP 488

Human   381 DQCGKYFSQNRQLKS------------H--------------YRVHTGHSLPECKDCHRKFMDVS 419
            ...|::...:.:|.|            |              |:.:...:.|..:|..       
  Fly   489 SSAGQFMDDDLELLSLNDQQDKSDEPDHEMVTLADENAGLPGYQGNEAEATPAQEDSP------- 546

Human   420 QLKKHLRTHTGEKPFTCEICGKSFTAKSSLQTHIRIHRG-------------------------- 458
                  ...|...|......||. .||..:|.. |:.|.                          
  Fly   547 ------AAETATAPPPAPRSGKK-GAKRPIQRR-RVRRKAQSTLDDQAEHLTEMSVRGLDLFRYA 603

Human   459 ---EKPYSCGICG-----KSFSDSSAKRRHCIL-HTGK--KPFSCPECNLQFARLDNLKAHLKI- 511
               |..|.|..|.     |:|.:..:.:||..| |.||  |.|.||.|:.:|:|.|.:|.|||: 
  Fly   604 SVVEGVYRCTECAKENMQKTFKNKYSFQRHAFLYHEGKHRKVFPCPVCSKEFSRPDKMKNHLKMT 668

Human   512 HSKEKHASDASS-------ISGSSNTEEVRNILQLQP--YQLSTSGEQEIQLLVTDSVHNINFMP 567
            |.......|..:       ||.::..:....|.|.|.  |....:.:.|.|....||..:...:|
  Fly   669 HENFTPPKDIGAFSPLKYLISAAAAGDMHATIYQQQQDHYHRQLAEQLEQQNASFDSRDSSLILP 733

Human   568 GPSQGISIVTAESSQNMTADQAANLT---LLTQQPEQLQNLILSAQQEQTEHIQSLNMIESQMGP 629
            .       |..|.:::..|:|.|.|:   .....|......:||.||:    :...:.|:....|
  Fly   734 D-------VKMEHAEDQDAEQEAELSDGGYDASNPAAAAAAMLSLQQD----VIIKDEIQISPSP 787

Human   630 SQTEP 634
            |.|.|
  Fly   788 SPTPP 792

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ZBTB24NP_055612.2 BTB 27..133 CDD:306997 34/107 (32%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 131..176 18/87 (21%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 209..254 5/47 (11%)
C2H2 Zn finger 296..316 CDD:275368 5/52 (10%)
COG5048 <321..480 CDD:227381 36/232 (16%)
C2H2 Zn finger 324..344 CDD:275368 3/19 (16%)
C2H2 Zn finger 352..372 CDD:275368 7/19 (37%)
C2H2 Zn finger 380..400 CDD:275368 5/45 (11%)
C2H2 Zn finger 408..428 CDD:275368 1/19 (5%)
C2H2 Zn finger 436..456 CDD:275368 6/19 (32%)
C2H2 Zn finger 464..480 CDD:275368 4/20 (20%)
C2H2 Zn finger 492..512 CDD:275368 10/20 (50%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 652..697
ttkNP_001189329.1 BTB 23..119 CDD:279045 34/102 (33%)
BTB 34..119 CDD:197585 33/91 (36%)
C2H2 Zn finger 612..638 CDD:275370 7/25 (28%)
zf-C2H2_4 646..669 CDD:290605 11/22 (50%)
C2H2 Zn finger 648..669 CDD:275370 10/20 (50%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.910

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