DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ZBTB24 and fru

DIOPT Version :9

Sequence 1:	NP_055612.2	Gene:	ZBTB24 / 9841	HGNCID:	21143	Length:	697	Species:	Homo sapiens
Sequence 2:	NP_001163648.1	Gene:	fru / 42226	FlyBaseID:	FBgn0004652	Length:	960	Species:	Drosophila melanogaster

Alignment Length:	835	Identity:	144/835 - (17%)
Similarity:	220/835 - (26%)	Gaps:	374/835 - (44%)

- Green bases have known domain annotations that are detailed below.

Human    36 LCDITLIVENVHFRAHKALLAASSEYFSMMFAEEGEIGQSIYMLEGMVADTFGILLEFIYTGYLH 100
            |||:||..|....:||:.:|:|.|.||..:|.:.......||:.:...:: ...||:|:|.|.::
  Fly   135 LCDVTLACEGETVKAHQTILSACSPYFETIFLQNQHPHPIIYLKDVRYSE-MRSLLDFMYKGEVN 198

Human   101 ASEKSTEQILATAQFLKVYDLVKAYTDFQN-NHSS-----------------PKPTTLNTAGAPV 147
            ..:.|....|.||:.|:    |:..||..| |:.|                 |...|....||..
  Fly   199 VGQSSLPMFLKTAESLQ----VRGLTDNNNLNYRSDCDKLRDSAASSPTGRGPSNYTGGLGGAGG 259

Human   148 VVISNKKNDPPKRKRGR--------PKKVNTLQEEKSELAA------------------------ 180
            |..:.:::....|.|..        .:..:::.|..|..||
  Fly   260 VADAMRESRDSLRSRCERDLRDELTQRSSSSMSERSSAAAAAAAAAAAVAAAGGNVNAAAVALGL 324

Human   181 ---------------------------------------------------------EEEIQLRV 188
                                                                     ::.:||..
  Fly   325 TTPTGGERSPSVGSASAAAAAAAVAAAVAAAANRSASADGCSDRGSERGTLERTDSRDDLLQLDY 389

Human   189 NNSVQNRQNFVVKG------------DSGVLNEQIAAKEKEESEPTCEPSREEEMPVEKDENYDP 241
            :|...|..|....|            .|...|...:.:|:..|     ..||.|...|::.:.|.
  Fly   390 SNKDNNNSNSSSTGGNNNNNNNNNNNSSSNNNNSSSNRERNNS-----GERERERERERERDRDR 449

Human   242 KTEDGQASQSRYSKRRIWRSVKLKDYKLVGDQED-HGSAKRICGRRKRP----GGPEARCKDCGK 301
            :.......|...||||...|....|..|....:| |.........:..|    ||..:..:|.|.
  Fly   450 ELSTTPVEQLSSSKRRRKNSSSNCDNSLSSSHQDRHYPQDSQANFKSSPVPKTGGSTSESEDAGG 514

Human   302 VFKYNHFLAIHQRSHTGERPFKCNECG--KGFAQKHSL----------QVHTRMHTGERP-YTCT 353
              :::..|::....|.|..........  .|.:|..|:          |.|...|....| |..:
  Fly   515 --RHDSPLSMTTSVHLGGGGGNVGAASALSGLSQSLSIKQELMDAQQQQQHREHHVALPPDYLPS 577

Human   354 VCSK-------ALTTKHSL--LEHMSLHSGQKSFTCDQCG------KYFS------QNRQLKSHY 397
            ...|       .|.|:|:|  .:....|:..|....||..      |.|:      .:|:|..::
  Fly   578 AALKLHAEDMSTLLTQHALQAADARDEHNDAKQLQLDQTDNIDGRVKCFNIKHDRHPDRELDRNH 642

Human   398 RVHTG--------------------------------HSLP------------------------ 406
            |.|..                                |:.|
  Fly   643 REHDDDPGVIEEVVVDHVREMEAGNEHDPEEMKEAAYHATPPKYRRAVVYAPPHPDEEAASGSGS 707

Human   407 ------------ECKD-------C----------------HRKFMDV------------------ 418
                        :||:       |                ||..:|.
  Fly   708 DIYVDGGYNCEYKCKELNMRAIRCSRQQHMMSHYSPHHPHHRSLIDCPAEAAYSPPVANNQAYLA 772

Human   419 ------------------SQLKKH--LRTH-----------------TGEKPFTCEICGKSFTAK 446
                              .||.:|  ..||                 .|....:..|.|.:..:.
  Fly   773 SNGAVQQLDLSTYHGHANHQLHQHPPSATHPSHSQSSPHYPSASGAGAGAGSVSVSIAGSASGSA 837

Human   447 SSLQTHI---------------------------------RIHR-----------GEKP--YSCG 465
            :|....:                                 |.|.           |..|  |.|.
  Fly   838 TSAPASVATSAVSPQPSSSSTGSTSSAAAVAAAAAAAANRRDHNIDYSTLFVQLSGTLPTLYRCV 902

Human   466 ICGKSFSDSSAKRRHCILHTGKKPFS--CPECNLQFARLDNLKAHLKIHSKEKHA 518
            .|.|..|:   :..|..:|   :|.|  ||.|..:|.|.||:|||.||    |||
  Fly   903 SCNKIVSN---RWHHANIH---RPQSHECPVCGQKFTRRDNMKAHCKI----KHA 947

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ZBTB24	NP_055612.2	BTB	27..133	CDD:306997	31/97 (32%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	131..176		10/69 (14%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	209..254		8/44 (18%)
		C2H2 Zn finger	296..316	CDD:275368	3/19 (16%)
		COG5048	<321..480	CDD:227381	49/384 (13%)
		C2H2 Zn finger	324..344	CDD:275368	5/31 (16%)
		C2H2 Zn finger	352..372	CDD:275368	5/28 (18%)
		C2H2 Zn finger	380..400	CDD:275368	7/31 (23%)
		C2H2 Zn finger	408..428	CDD:275368	9/80 (11%)
		C2H2 Zn finger	436..456	CDD:275368	4/52 (8%)
		C2H2 Zn finger	464..480	CDD:275368	4/15 (27%)
		C2H2 Zn finger	492..512	CDD:275368	11/19 (58%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	652..697
fru	NP_001163648.1	BTB	126..221	CDD:279045	27/90 (30%)
		BTB	137..221	CDD:197585	25/88 (28%)
		C2H2 Zn finger	901..918	CDD:275368	5/19 (26%)
		C2H2 Zn finger	925..944	CDD:275368	10/18 (56%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910