DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ZBTB24 and CG2120

DIOPT Version :9

Sequence 1:	NP_055612.2	Gene:	ZBTB24 / 9841	HGNCID:	21143	Length:	697	Species:	Homo sapiens
Sequence 2:	NP_572446.2	Gene:	CG2120 / 31737	FlyBaseID:	FBgn0030005	Length:	315	Species:	Drosophila melanogaster

Alignment Length:	310	Identity:	92/310 - (29%)
Similarity:	139/310 - (44%)	Gaps:	49/310 - (15%)

- Green bases have known domain annotations that are detailed below.

Human   238 NYDPKTEDGQ--ASQSRYSKRRIWRSVKL----KDYKLV----GDQEDHGSAKR----IC----- 283
            |||...||.|  |.....|..|:...::|    .:|.|:    |..:...:.:.    :|
  Fly    22 NYDVCLEDLQLFAQLEDLSGERLPMEMELLNPGSEYDLLELVNGALQQRNTTEHKPTDMCKPKRT 86

Human   284 --GRRKRPGGPEARCKDCGKVFKYNHFLAIHQRSHTGERPFKCNECGKGFAQKHSLQVHTRMHTG 346
              .:|.|..|.:..|..|.:.|...:.|.||:.:||.|:|..|.||||||.|.:.|::|...||.
  Fly    87 PTTKRHRTTGKDHTCDICDRRFSEAYNLRIHKMTHTDEKPHVCVECGKGFRQLNKLRIHAVTHTA 151

Human   347 ERPYTCTVCSKALTTKHSLLEHMSLHSGQKSFTC--DQCGKYFSQNRQLKSHYRVHTGHSLPECK 409
            |||:.|.:|.|.....:.|..|..||:|:|.:.|  ..|            |...|:.|:    :
  Fly   152 ERPHKCDICGKGFRYANYLTVHRRLHTGEKPYPCLATDC------------HLSFHSIHA----R 200

Human   410 DCHRKFMDVSQ--------LKKHLRTHTGEKPFTCEICGKSFTAKSSLQTHIRIHRGEKPYSC-- 464
            ..|.|....:|        |.:..:..|....|||.:|.:..|.:..|..|::.|..::.:.|
  Fly   201 RIHTKLRHAAQTDPDPEHPLAEQEQRDTSALSFTCPVCSRVLTDQCYLSIHLKRHYNQRDFPCPQ 265

Human   465 GICGKSFSDSSAKRRHCILHTGKKPFSCPECNLQFARLDNLKAHLKIHSK 514
            ..|||.|..:|..:.|.|.||.::||:||.|..:|.|..|.|.|||:|.:
  Fly   266 PECGKRFFSASELKHHQIAHTQQRPFACPLCPARFLRKSNHKQHLKVHER 315

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ZBTB24	NP_055612.2	BTB	27..133	CDD:306997
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	131..176
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	209..254		7/17 (41%)
		C2H2 Zn finger	296..316	CDD:275368	6/19 (32%)
		COG5048	<321..480	CDD:227381	49/170 (29%)
		C2H2 Zn finger	324..344	CDD:275368	10/19 (53%)
		C2H2 Zn finger	352..372	CDD:275368	5/19 (26%)
		C2H2 Zn finger	380..400	CDD:275368	3/21 (14%)
		C2H2 Zn finger	408..428	CDD:275368	4/27 (15%)
		C2H2 Zn finger	436..456	CDD:275368	5/19 (26%)
		C2H2 Zn finger	464..480	CDD:275368	6/17 (35%)
		C2H2 Zn finger	492..512	CDD:275368	10/19 (53%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	652..697
CG2120	NP_572446.2	C2H2 Zn finger	101..121	CDD:275368	6/19 (32%)
		zf-H2C2_2	113..138	CDD:290200	14/24 (58%)
		C2H2 Zn finger	129..149	CDD:275368	10/19 (53%)
		zf-H2C2_2	142..166	CDD:290200	10/23 (43%)
		COG5048	151..>264	CDD:227381	30/128 (23%)
		C2H2 Zn finger	157..177	CDD:275368	5/19 (26%)
		C2H2 Zn finger	185..206	CDD:275368	6/36 (17%)
		C2H2 Zn finger	235..255	CDD:275368	5/19 (26%)
		C2H2 Zn finger	263..285	CDD:275368	8/21 (38%)
		C2H2 Zn finger	293..313	CDD:275368	10/19 (53%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S4068
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.950