Protein Alignment RB1CC1 and Atg17

DIOPT Version :10

• Sequence 1: XP_016869592.1
• Gene: RB1CC1 / 9821
• HGNCID: 15574
• Length: 1601
• Species: Homo sapiens
• Sequence 2: NP_649573.2
• Gene: Atg17 / 40700
• FlyBaseID: FBgn0037363
• Length: 1357
• Species: Drosophila melanogaster
• Alignment Length: 1619
• Identity: 376/1619 - (23%)
• Similarity: 585/1619 - (36%)
• Gaps: 566/1619 - (34%)

Human     1 MKLYVFLVNTGTTLTFDTELTVQTVADLKHAIQSKYKIAIQHQVLVVNGGECMAADRRVCTYSAG 65
            |.||||.|:.|..|:||..:.:|.|..||..||..:.|...:.||:|:|||.:....:|..||||
  Fly     1 MMLYVFHVDVGRMLSFDMNVALQPVEHLKETIQKLHNIPAANIVLLVSGGEMLTHSTQVSCYSAG 65

Human    66 TDTNPIFLFNKEMILCDRPPAIPKTTFSTENDMEIK--VEESLMMPAVFHTVASRTQLALEMYEV 128
            ||||||::|    :..|.  .:|.|.::::.|.|::  ||||..:|....||..|.|||..|.|:
  Fly    66 TDTNPIYMF----LTGDE--RLPPTIYNSDADNELRRQVEESHRLPPALETVRQRAQLAQHMREL 124

Human   129 AKKLCSFCEGLVHDEHLQHQGWAAIMANLEDCSNSYQKLLFKFESIYSNYLQSIEDIKLKLTHLG 193
            |:|....||.|||::|||.|||:|::||:||.:|.:......|.|.:..:||..|.....|.:..
  Fly   125 ARKEEDQCERLVHEQHLQQQGWSAVVANMEDLTNEFCDRFQNFCSFFDRHLQKRESFLELLRNFP 189

Human   194 TAVSVMAKIPLLECLTRHSYRECLGRLDSLPEHEDSEKAEMKRSTELVLSPDMPRTTNESLLTSF 258
            ..:..:.:||:|..|...:..:..| .|.|.:::|...|:.:.      :|.....|..|...|.
  Fly   190 DDLKQLGRIPILPDLMSLAEADFHG-FDELLDNDDVFTAQQQP------TPQQQALTESSQADSP 247

Human   259 PKSVEHVSPDTADAESGKEIRESCQSTVHQQDETTIDTKDGDL---PFFNVSLLDWINVQDRPND 320
            .|.::  ..|..:.|||::.....|:.          |....|   |  |::||.||:.:.....
  Fly   248 NKKLK--MGDEVETESGEQTERGVQTL----------TSSSSLARRP--NLNLLQWISSKGNHRA 298

Human   321 VESLVRKCFDSMSRLDPRIIRPFIAECRQTIAKLDNQ-NMKAIKGLEDRLYALDQMIASCGRLVN 384
            ::.:..:|...:......|......|..| |.||.|| ::|.||||.|||..|::......::|.
  Fly   299 LQLMSDECIQGLDVFSVEIYEKLKEEVNQ-IIKLANQADVKEIKGLGDRLCKLEEFKFRIKKMVQ 362

Human   385 EQKELAQGFLANQKRAENLKDASVLPDLCLSHANQLMIMLQNHRKLLDIKQKCTTAKQELANNLH 449
            ||||.|.....|:.||:||:|.||||||||||.:||.:||.||.|:.:..:....:|.||..|||
  Fly   363 EQKEQALALQQNEARAQNLRDNSVLPDLCLSHRSQLQVMLDNHIKIREYCRCIANSKDELGWNLH 427

Human   450 VRLKWCCFVMLHADQDGEKLQALLRLVIELLERVKIVEALSTVPQMYCLAVVEVVRRKMFIKHYR 514
            .||:...::.....:...:|....|.:......:.|:|.:...|..|..||.||||||:|...:|
  Fly   428 TRLRRIVWIENGMSEFDNRLLFNHRCLRRAERHICIIEQIHRAPSTYVSAVAEVVRRKIFSDEFR 492

Human   515 EWAGALVKDGKRLYEAEKSKRESFGKLFRKSFLRNRLFRGLDSWPPSFCTQKPRKFDCELPDISL 579
            :||..|..|..|::..|.|:|..|...|...|| |.||.|:...||:|..:.|..||..||.:|.
  Fly   493 QWATRLSADFDRIHSEELSRRRDFNASFEGHFL-NILFPGMGDMPPAFANEHPLSFDTRLPSLSR 556

Human   580 KDLQFLQSFCPSEVQPFLRVPLLCDFEPLHQHVLALHNLVKAAQSLDEMSQTITDLLSEQKASVS 644
            .|::.|.|..| |:...|::|   |.:|:
  Fly   557 SDMELLSSQLP-ELAGQLQLP---DMKPV------------------------------------ 581

Human   645 QTSPQSASSPRMESTAGITTTTSPRTPPPLTVQDPLCPAVCPLEELSPDSIDAHTFDFETIPHPN 709
                                                              ||......:....|:
  Fly   582 --------------------------------------------------IDFFALRSDKNVEPD 596

Human   710 IEQTIHQVSLDLDSLAESPESDFMSAVNEFVIEENLSSPNPISDPQSPEMMVESLYSSVINAIDS 774
            .||                |.|.                 |:..|:..|:..::
  Fly   597 QEQ----------------ERDI-----------------PLMAPRLAELQAQA----------- 617

Human   775 RRMQDTNVCGKEDFGDHTSLNVQLERCRVVAQDSHFSIQTIKEDLCHFRTFVQKEQCDFSNSLKC 839
                                         .|.|.....:|..|.|              |.:.||
  Fly   618 -----------------------------AASDCETDTETEFEKL--------------STTSKC 639

Human   840 TAVEI-RNIIEKVKCSLEITLKEKHQKELLSLKNEYEGKLDGLIKETEENENKIKKLKGELVCLE 903
            .|..| .:::|:|..|   |..|    :||.|.   .|.|      ||||....:|::.::..:
  Fly   640 VATSISTSLVEQVAQS---TATE----DLLMLS---AGTL------TEENAGSFEKMRSDMESM- 687

Human   904 EVLQNKDNEFALVKHEKEAVICLQNEKDQKLLEMENIMHSQNCEIKELKQSREIVLEDLKKLHVE 968
                           .|.|..||                      .|.:.:..:...|:.....|
  Fly   688 ---------------TKLARACL----------------------AEARSNVGVFRSDVANYQDE 715

Human   969 NDEKLQLLRAELQSLEQSHLKELEDTLQVRHIQEFEKVMTDHRVSLEELKKENQQIINQIQESHA 1033
            ...:|.|||.:...|:.
  Fly   716 LQSELHLLRDKCNVLKM------------------------------------------------ 732

Human  1034 EIIQEKEKQLQELKLKVSDLSDTRCKLEVELALKEAETDEIKILLEESRAQQKETLKSLLEQETE 1098
             :.:|:|::|||                        :.||:.:.|:            |.|||.
  Fly   733 -MCEEREQKLQE------------------------KLDEMSLKLQ------------LAEQEK- 759

Human  1099 NLRTEISKLNQKIQDNNENYQVGLAELRTLMTIEKDQCISELISRHEEESNILKAELNKVTSLHN 1163
                                |..:|:.|           .:||..|:.|...|:.....:||:.
  Fly   760 --------------------QAAVAQAR-----------EQLIHEHKTELESLRCRFKLMTSME- 792

Human  1164 QAFEIEKNLKEQIIELQSKLDSELSALERQKDEKITQQEEKYEAIIQNLEKDRQKLVSSQEQDRE 1228
                            :|..||.|        |||.:.......:..|...|...|::.|.|:
  Fly   793 ----------------RSPSDSSL--------EKIERPTSSASVVSANAGVDIDHLLAQQRQE-- 831

Human  1229 QLIQKLNCEKDEAIQTALKEFKLEREVVEKELLEKVKHLENQIAKSPAIDSTRGDSSSLVAE--L 1291
                 |..:::.||..|:..   ||.:.:..||..                   :|.|::|.  :
  Fly   832 -----LLAQRERAISEAVDS---ERSLWQSRLLPL-------------------NSESVMANVGI 869

Human  1292 QEKLQEEKAKFLEQLEEQEKRKNEEMQNVRTSLIAEQQTNFNTVLTREKMRKENIINDLSDKLKS 1356
            .:.:..:|.:.|:||.||.|...:|...::|.|  |..||                .|.:..||.
  Fly   870 LKDMLADKERQLDQLREQNKILTQETYQLKTRL--EMITN----------------EDGNSWLKE 916

Human  1357 TMQQQERDK-DLIESLSEDRARLLEEKKKLEEEVSKLRSSSF---VPSPYVATAPELYGACAPEL 1417
            .:....:|| .|.|.||::::|    ::::|..|:.:|||::   |..|
  Fly   917 KIDYLNKDKCRLEEELSQEKSR----RQEMESSVAAMRSSAYDLNVGGP---------------- 961

Human  1418 PGESDRSAVETADEGRVDSAMETSMMSVQENIHMLSEEKQRIMLLERVSFFHLQTLQLKEEENKR 1482
                                                                             
  Fly   962 ----------------------------------------------------------------- 961

Human  1483 LNQRLMSQSMSSVSSRHSEKIAIRDFQVGDLVLIILDERHDNYVLFTVSPTLYFLHSESL----- 1542
                 :::|.|.|||.| ..||:.....||||.::...||..:::...|.||||:|::||
  Fly   962 -----LTRSKSGVSSSH-RSIALEGCARGDLVFVVWSMRHAQFMVVQDSLTLYFVHADSLASLQL 1020

Human  1543 -----PALDLKPGEGASGASRRP---WVLGKVMEKEYCQAKKAQNRFKVPLGTKFYRVK 1593
                 |...|.|.:.....::.|   :.:|:|::||||||:|..||::|..|:||||:|
  Fly  1021 TAPTSPTPSLDPSQTVVDINQIPLPYYAIGRVIDKEYCQARKDDNRYRVSRGSKFYRIK 1079

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
RB1CC1	XP_016869592.1	Ubl_RB1CC1	2..76	CDD:340580	34/73 (47%)
		ATG17_like	<404..538	CDD:427715	50/133 (38%)
		Mplasa_alph_rch	871..1375	CDD:275316	86/506 (17%)
		ATG11	<1501..1595	CDD:463063	38/106 (36%)
Atg17	NP_649573.2	Ubl_RB1CC1	2..74	CDD:340580	33/71 (46%)
		ATG17_like	107..525	CDD:427715	141/439 (32%)
		SMC_N	<678..>958	CDD:481474	86/510 (17%)
		ATG11	943..1082	CDD:463063	51/224 (23%)
		DUF5585	<1077..>1324	CDD:465521	2/3 (67%)